2,6-Difluoropyridine-4-boronic acid
- CAS No.
- 401816-16-8
- Chemical Name:
- 2,6-Difluoropyridine-4-boronic acid
- Synonyms
- 2,6-Difluoropyridine-4-boronicaci;2,6-DIFLUORO-4-PYRIDYLBORONIC ACID;2,6-DIFLUOROPYRIDINE-4-BORONIC ACID;(2,6-DIFLUOROPYRIDIN-4-YL)BORONIC ACID;B-(2,6-Difluoro-pyridin-4-yl)boronic acid;B-(2,6-difluoro-4-pyridinyl)-Boronic acid;Boronic acid, B-(2,6-difluoro-4-pyridinyl)-;Boronic acid, (2,6-difluoro-4-pyridinyl)- (9CI);2,6-Difluoropyridine-4-boronic acid ISO 9001：2015 REACH
- CBNumber:
- CB5738508
- Molecular Formula:
- C5H4BF2NO2
- Molecular Weight:
- 158.9
- MDL Number:
- MFCD04114289
- MOL File:
- 401816-16-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xi |
| Risk Statements | 37/38-41 |
| Safety Statements | 26-39 |
| Hazard Note | Irritant |
| HS Code | 2933399990 |
2,6-Difluoropyridine-4-boronic acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC7034 | 2,6-Difluoropyridine-4-boronic acid ≥95% | 401816-16-8 | 100mg | $43 | 2026-06-04 | Buy |
| Apolloscientific | PC7034 | 2,6-Difluoropyridine-4-boronic acid ≥95% | 401816-16-8 | 250mg | $82 | 2026-06-04 | Buy |
| Activate Scientific | AS143588 | (2,6-Difluoropyridin-4-yl)boronic Acid 96% | 401816-16-8 | 1g | $133 | 2026-06-04 | Buy |
| Activate Scientific | AS143588 | (2,6-Difluoropyridin-4-yl)boronic Acid 96% | 401816-16-8 | 5g | $425 | 2026-06-04 | Buy |
| Matrix Scientific | 299169 | (2,6-Difluoropyridin-4-yl)boronic acid | 401816-16-8 | 250.00mg | $52 | 2026-05-19 | Buy |
2,6-Difluoropyridine-4-boronic acid Chemical Properties, Uses, Production
Synthesis
903513-58-6
5419-55-6
401816-16-8
The final step in the synthesis of 2,6-difluoropyridine-4-boronic acid involves the lithiation of 2,6-difluoro-4-hydrazinylpyridine followed by reaction with triisopropyl borate. This was done as follows: tetrahydrofuran (150 mL) and toluene (400 mL) were added to the reaction flask. Triisopropyl borate (47 g, 0.25 mol) and 4-bromo-2,6-difluoropyridine (44 g, 0.22 mol) were added to the reaction vessel under nitrogen protection and the mixture was cooled to -75 °C. The reaction was carried out in the reaction vessel with the help of a dosing funnel. n-Butyllithium (2.6 M hexane solution, 105 mL, 0.27 mol) was added slowly dropwise through the addition funnel, with the rate of dropwise acceleration controlled to keep the reaction temperature from exceeding -70 °C. After dropwise addition, stirring was continued at -75 °C for 30 min, after which the cooling bath was removed and the reaction mixture was allowed to warm up to -20 °C naturally. The reaction was quenched with 2N hydrochloric acid (~120 mL), pH adjusted to 2, and stirred for 30 minutes. The organic phase was separated and the aqueous phase was extracted twice with ether (250 mL x 2). The organic phases were combined, washed sequentially with water (500 mL) and brine (250 mL), dried over anhydrous magnesium sulfate, decolorized by the addition of activated charcoal for 1 h, filtered through diatomaceous earth and concentrated under reduced pressure. Hexane (250 mL) was added to the residue to precipitate the solid product. The mixture was refrigerated overnight, the solid was collected by filtration, washed with cold hexane and dried. Since 1H NMR analysis showed butylboronic acid impurities in the product, the solid was stirred with hexane (250 mL) at 45 °C for 30 min, hot filtered and washed with cold hexane to give 11.8 g (33% yield) of the target product 2,6-difluoropyridine-4-boronic acid.1H NMR (DMSO-d6, 400 MHz): δ 7.31 (s, 2H).
References
[1] Patent: US7087755, 2006, B1. Location in patent: Page/Page column 5
2,6-Difluoropyridine-4-boronic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
View Latest Price from 2,6-Difluoropyridine-4-boronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 2,6-Difluoropyridine-4-boronic acid
401816-16-8
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-01-19 | 2,6-Difluoropyridine-4-boronic acid
401816-16-8
|
$3.00 | 1KG | 98% | 1kg,5kg,50kg | Career Henan Chemical Co | |
 |
2019-12-20 | 2,6-Difluoropyridine-4-boronic acid
401816-16-8
|
1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
-
- 2,6-Difluoropyridine-4-boronic acid
401816-16-8
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 2,6-Difluoropyridine-4-boronic acid
401816-16-8
- $3.00
- 98%
- Career Henan Chemical Co
-
- 2,6-Difluoropyridine-4-boronic acid
401816-16-8
- $0.00
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
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