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2-Fluoropyridine-4-boronic acid

2-Fluoropyridine-4-boronic acid structure

CAS No.: 401815-98-3

Chemical Name:: 2-Fluoropyridine-4-boronic acid

Synonyms: CAS:401815-98-3;uoropyridin-4-yL;4-Borono-2-fluoropyridine;2-FLUOROPYRIDINE-BORONIC ACID;2-Fluoropyridine-4-boronicaci;2-Fluoro-4-pyridylboronic acid;2-fluoro-4-pyridine boric acid;2-FLUORO-4-PYRIDINEBORONIC ACID;2-FLUOROPYRIDINE-4-BORONIC ACID;2-FLUORO-4-PYRIDINYLBORONIC ACID

CBNumber:: CB0438900

Molecular Formula:: C5H5BFNO2

Molecular Weight:: 140.91

MDL Number:: MFCD04112534

MOL File:: 401815-98-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 22:43:02

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2-Fluoropyridine-4-boronic acid Properties

Melting point	ca 195℃
Boiling point	326.8±52.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	soluble in Methanol
form	powder to crystal
pka	6.51±0.10(Predicted)
color	White to Almost white
InChI	1S/C5H5BFNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3,9-10H
InChIKey	WXGBZJJAGLSBPR-UHFFFAOYSA-N
SMILES	OB(O)c1ccnc(F)c1
CAS DataBase Reference	401815-98-3(CAS DataBase Reference)
UNSPSC Code	12352106

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Risk Statements

36/37/38

Safety Statements

26-37

WGK Germany

WGK 3

Hazard Note

Irritant

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

2-Fluoropyridine-4-boronic acid price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	F0935	2-Fluoropyridine-4-boronic Acid (contains varying amounts of Anhydride)	401815-98-3	1g	$54	2026-04-30	Buy
TCI Chemical	F0935	2-Fluoropyridine-4-boronic Acid (contains varying amounts of Anhydride)	401815-98-3	5g	$268	2026-04-30	Buy
Usbiological	277966	2-Fluoropyridine-4-boronic acid Asreported	401815-98-3	500mg	$347	2026-06-03	Buy
Usbiological	277966	2-Fluoropyridine-4-boronic acid Asreported	401815-98-3	1g	$503	2026-06-03	Buy
Usbiological	277966	2-Fluoropyridine-4-boronic acid Asreported	401815-98-3	2g	$685	2026-06-03	Buy

Product number	Packaging	Price	Buy
F0935	1g	$54	Buy
F0935	5g	$268	Buy
277966	500mg	$347	Buy
277966	1g	$503	Buy
277966	2g	$685	Buy

2-Fluoropyridine-4-boronic acid Chemical Properties, Uses, Production

Chemical Properties

Solid

Uses

2-Fluoropyridine-4-boronic Acid is used to synthesize analogues of the antitubercular drug.

Synthesis

5419-55-6

128071-98-7

401815-98-3

Step 1: 4-bromo-2-fluoropyridine (30.0 g, 0.17 mol) and triisopropyl borate (38.4 g, 0.20 mol) were dissolved in a solvent mixture of anhydrous toluene and tetrahydrofuran (THF) (4:1, 250 mL) under nitrogen protection. The reaction mixture was cooled to -78 °C, followed by slow dropwise addition of n-butyllithium (80 mL, 0.20 mol, 2.5 M hexane solution) over 30 min. After the dropwise addition was completed, stirring was continued at -78 °C for 30 min. The reaction mixture was then slowly warmed up to -20°C over 1 hr. The progress of the reaction was monitored by thin layer chromatography (TLC) (unfolding agent: petroleum ether (PE):ethyl acetate (EtOAc) = 1:1) to confirm that the raw materials were completely consumed. Upon completion of the reaction, the mixture was acidified to pH 2 with 3N HCl (50 mL) and stirred at room temperature for 15 minutes. The reaction mixture was transferred to a partition funnel and extracted with EtOAc (150 mL) and water (150 mL). The organic layer was separated, washed sequentially with water and brine, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to give (2-fluoropyridin-4-yl)boronic acid (22.0 g, 91% yield) as a white solid.

References

[1] Patent: WO2015/103137, 2015, A1. Location in patent: Paragraph 00178
[2] Patent: US7087755, 2006, B1. Location in patent: Page/Page column 6
[3] Patent: US2004/122237, 2004, A1. Location in patent: Page 201

2-Fluoropyridine-4-boronic acid synthesis

Synthesis of 2-Fluoropyridine-4-boronic acid from Triisopropyl borate and 4-Bromo-2-fluoropyridine

2-Fluoropyridine-4-boronic acid Preparation Products And Raw materials

Raw materials

4-Bromo-2-fluoropyridine 2-Fluoro-4-iodopyridine Triisopropyl borate Hexane Tetrahydrofuran

Tributyl borate Toluene n-Butyllithium

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Preparation Products

Pyrimidine, 2-chloro-5-fluoro-4-(2-fluoro-4-pyridinyl)-

2-Fluoropyridine-4-boronic acid Suppliers

Global Suppliers ( 276)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
INTATRADE GmbH	66
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60

View Latest Price from 2-Fluoropyridine-4-boronic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	2-Fluoropyridine-4-boronic acid 401815-98-3	$1.00	1kg	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	2-Fluoropyridine-4-boronic acid 401815-98-3		1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-08-12	2-Fluoropyridine-4-boronic acid 401815-98-3	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

2-Fluoropyridine-4-boronic acid
401815-98-3
$1.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Fluoropyridine-4-boronic acid
401815-98-3
98%
Henan Aochuang Chemical Co.,Ltd.

2-Fluoropyridine-4-boronic acid
401815-98-3
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Fluoropyridine-4-boronic acid Spectrum

2-Fluoropyridine-4-boronic acid(401815-98-3)¹HNMR 2-Fluoropyridine-4-boronic acid(401815-98-3)FT-IR

401815-98-3 (2-Fluoropyridine-4-boronic acid) Related Search:

Flupirtine 4-Bromo-2-fluoropyridine 3-Pyridylboronic acid 2-Fluoro-4-iodopyridine Potassium tetrafluoroborate

2-Pyridineboronic acid Sodium tetrafluoroborate Pyridine-4-boronic acid 2-Fluoropyridine 2,6-Lutidine

Fluoroboric acid Ammonium fluoborate 2-Chloro-3-cyanopyridine 2,6-Difluoropyridine-4-boronic acid 2-Fluoropyridine-4-boronic acid pinacol ester

3-Chloro-2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine (5-Chloro-2-fluoropyridin-4-yl)boronic acid 2-Fluoropyridine-5-boronic acid

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2-FLUOROPYRIDINE-4-BORONIC ACID 2-FLUOROPYRIDIN-4-YLBORONIC ACID 2-FLUORO-4-PYRIDINEBORONIC ACID 2-FLUORO-4-PYRIDINYLBORONIC ACID Boronic acid, (2-fluoro-4-pyridinyl)- (9CI) 2-Fluoro-4-pyridinylboronic acid ,97% 2-fluoropyridin-4-yl-4-boronic acid 4-Borono-2-fluoropyridine 2-FLUOROPYRIDINE-BORONIC ACID BORONICACID, B-(2-FLUORO-4-PYRIDINYL)- 2-Fluoro-4-pyridylboronic acid 2-Fluoropyridine-4-boronic Acid (contains varying amounts of Anhydride) B-(2-Fluoro-pyridin-4-yl)boronic acid 2-fluoro-4-pyridine boric acid uoropyridin-4-yL 2-Fluoropyridine-4-boronicaci CAS:401815-98-3 2-Fluoropyridine-4-boronic acid - [F2370] 401815-98-3 Boronate Ester Potassium Trifluoroborate PYRIDINE Pyridines Boronic acid Organoborons