NF 449
- CAS No.
- 389142-38-5
- Chemical Name:
- NF 449
- Synonyms
- NF449;NF449 OCTASODIUM SALT;NF449 - CAS 389142-38-5 - Calbiochem;1,3-Benzenedisulfonic acid, 4,4',4'',4'''-[carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakis-;4,4',4'',4'''-[CARBONYL-BIS[IMINO-5,1,3-BENZENETRIYL BIS-(CARBONYLIMINO)]]TETRAKIS-(BENZENE-1,3-DISULFONIC ACID, 8NA);4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino)))tetrakis-1,3-benzenedisulfonicacid,octasodium;4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid octasodium salt;4,4',4'',4'''-[CARBONYLBIS(IMINO-5,1,3-BENZENETRIYL-BIS(CARBONYLIMINO))]TETRAKIS-1,3-BENZENEDISULFONIC ACID, OCTASODIUM SALT;4,4μ,4,4μ-[Carbonylbis[imino-5,1,3-benzenetriyl bis(carbonyl-imino)]]tetrakis(benzene-1,3-disulfonic acid) octasodium salt;4,4',4'',4'''-[CARBONYL-BIS[IMINO-5,1,3-BENZENETRIYL BIS-(CARBONYL-IMINO)]]TETRAKIS(BENZENE-1,3-DISULFONIC ACID) OCTASODIUM SALT
- CBNumber:
- CB5764453
- Molecular Formula:
- C41H32N6O29S8
- Molecular Weight:
- 1329.24
- MDL Number:
- MFCD03791135
- MOL File:
- 389142-38-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| NF449 | 480420 | 10mg | $227.55 |
| NF449 | 1391 | 10 | $236 |
| NF449 | 1391 | 50 | $992 |
| NF449 | 165610 | 10mg | $403 |
| NF 449 | 255975 | 10mg | $489 |
| Melting point | >300°C |
|---|---|
| Density | 1.991±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble |
| form | solid |
| pka | -2.03±0.50(Predicted) |
| color | white |
| Stability | Hygroscopic |
| FDA UNII | RV4PVU9V2A |
NF 449 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 480420 | NF449 | 389142-38-5 | 10mg | $227.55 | 2021-12-16 | Buy |
| Tocris | 1391 | NF449 | 389142-38-5 | 10 | $236 | 2021-12-16 | Buy |
| Tocris | 1391 | NF449 | 389142-38-5 | 50 | $992 | 2021-12-16 | Buy |
| Usbiological | 165610 | NF449 | 389142-38-5 | 10mg | $403 | 2021-12-16 | Buy |
| Usbiological | 255975 | NF 449 | 389142-38-5 | 10mg | $489 | 2021-12-16 | Buy |
NF 449 Chemical Properties,Uses,Production
Uses
NF449 is a known P2X1 receptor antagonist used to regulate the intravascular platelet aggregation commonly seen in systematic thromboembolism.
Biological Activity
Potent purinergic receptor antagonist that displays high selectivity for P2X 1 (IC 50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X 1 , rP2X 1+5 , rP2X 2+3 , rP2X 3 , rP2X 2 and P2X 4 receptors respectively). Provides antithrombotic protection in vivo . Also acts as a G s α -selective antagonist.
in vivo
At a dose of 10 mg/kg, NF449 inhibits the ex vivo aggregation triggered by 5 g/ml collagen in WT mouse platelets without affecting that induced by 5 μM ADP. At a higher dose (50 mg/kg), NF449 inhibits ex vivo platelet aggregation in response to not only 10 g/ml collagen but also 5 M ADP, indicating nonselective inhibition of the P2Y1 and/or P2Y12 receptor[3].
IC 50
p2x1 Receptor
NF 449 Preparation Products And Raw materials
Raw materials
Preparation Products
NF 449 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4032 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9863 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 2987 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25021 | 58 |
| Santa Cruz Biotechnology Inc | -- | scbt@scbt.com | China | 6594 | 58 |
| Shanghai Weijiahe Biotechnology Co., Ltd | 17502176150 | 861873257@qq.com | China | 2895 | 58 |
