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Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2

Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 Structure
Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 structure
CAS No.
77128-69-9
Chemical Name:
Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2
Synonyms
DiMe-C7;[pGlu5,MePhe8,Sar9]substance P(5-11);GLP-GLN-PHE-(NME)PHE-SAR-LEU-MET-NH2;Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2;[GLP5,(ME)PHE8,SAR9] SUBSTANCE P (5-11);(PYR5,N-ME-PHE8,SAR9)-SUBSTANCE P (5-11);Glp5, (NMe)Phe8, Sar9] Substance P(5-11);PGLU-GLN-PHE-N-METHYL-PHE-SAR-LEU-MET-NH2;PGLU5,MEPHE8,SAR9-SUBSTANCE P FRAGMENT*5 -11;substance P (5-11), pGlu(5)-MePhe(8)-MeGly(9)-
CBNumber:
CB5783997
Molecular Formula:
C43H61N9O9S
Molecular Weight:
880.07
MDL Number:
MFCD00133835
MOL File:
77128-69-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:53:41
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Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 Properties

Boiling point 1291.2±65.0 °C(Predicted)
Density 1.257±0.06 g/cm3(Predicted)
storage temp. −20°C
form Solid
pka 13.13±0.20(Predicted)
color White to off-white
Sequence pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2

SAFETY

Risk and Safety Statements

WGK Germany  3

Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FP109387 (Pyr 5,N-Me-Phe8, Sar 9)-Substance P (5-11) 77128-69-9 10mg $900 2026-06-04 Buy
Biosynth FP109387 (Pyr 5,N-Me-Phe8, Sar 9)-Substance P (5-11) 77128-69-9 5mg $900 2026-06-04 Buy
Biosynth FP109387 (Pyr 5,N-Me-Phe8, Sar 9)-Substance P (5-11) 77128-69-9 25mg $986.25 2026-06-04 Buy
Biosynth FP109387 (Pyr 5,N-Me-Phe8, Sar 9)-Substance P (5-11) 77128-69-9 50mg $1678 2026-06-04 Buy
Biosynth FP109387 (Pyr 5,N-Me-Phe8, Sar 9)-Substance P (5-11) 77128-69-9 100mg $2918 2026-06-04 Buy
Product number Packaging Price Buy
FP109387 10mg $900 Buy
FP109387 5mg $900 Buy
FP109387 25mg $986.25 Buy
FP109387 50mg $1678 Buy
FP109387 100mg $2918 Buy

Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 Chemical Properties, Uses, Production

Uses

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats[1][2][3].

in vivo

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (2 μg/side; inject into the ventral tegmental area; single) exhibits selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain[1].
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (0.5, 1.5, 3 μg/side; inject into the ventral tegmental area; single) increases motor activity and induces recovery of addictive agent-seeking behavior in rats[2].

Animal Model:Male Sprague-Dawley rats (300-350 g)[1].
Dosage:2 μg/side
Administration:Inject into the ventral tegmental area; single
Result:Selectively activated mesolimbic and mesocortical dopamine metabolism.
Animal Model:Male Wistar rats (300-350 g)[2].
Dosage:0.5, 1.5, 3 μg/side
Administration:Inject into the ventral tegmental area; single
Result:Significantly increased locomotor activity when at 3 μg/side.

References

[1] Elliott PJ, et al. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Brain Res. 1986 Jan 15;363(1):145-7. DOI:10.1016/0006-8993(86)90667-0
[2] Eison AS, et al. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Science. 1982 Jan 8;215(4529):188-90. DOI:10.1126/science.6171884
[3] Placenza FM, et al. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Psychopharmacology (Berl). 2004 Dec;177(1-2):111-20. DOI:10.1007/s00213-004-1912-9

Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 Suppliers

Global Suppliers ( 52)
Supplier Tel Email Country ProdList Advantage
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Cellmano Biotech Limited 0551-65326643 18156095617 info@cellmano.com China 1010 55
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9711 58
Nanjing Leon Biological Technology Co., Ltd. 025-84523390 -127; 17705183659 sales@njleonbiotech.com China 5501 55
Nanjing Peptide Biotech Ltd. 025-58361106-805 15951641583 zhao.xu@njpeptide.com China 9976 55
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 15967184799 Eric@peptidego.com China 7872 58
Chengdu Peter-like Biotechnology Co., Ltd. 18108052721 2850505130@qq.com China 5037 58
Cellmano Biotech Limited 0551-65326643 18156095617 info@cellmano.com China 995 58
Supplier Advantage
GL Biochem (Shanghai) Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
Cellmano Biotech Limited 55
Shanghai Chaolan Chemical Technology Center 58
Nanjing Leon Biological Technology Co., Ltd. 55
Nanjing Peptide Biotech Ltd. 55
Hangzhou Peptidego Biotech Co.,Ltd. 58
Chengdu Peter-like Biotechnology Co., Ltd. 58
Cellmano Biotech Limited 58

View Latest Price from Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PYR-GLN-PHE-N-ME-PHE-SAR-LEU-MET-NH2 pictures 2025-04-04 PYR-GLN-PHE-N-ME-PHE-SAR-LEU-MET-NH2
77128-69-9
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
PYR-GLN-PHE-N-ME-PHE-SAR-LEU-MET-NH2 pictures 2020-03-06 PYR-GLN-PHE-N-ME-PHE-SAR-LEU-MET-NH2
77128-69-9
 $1.00 1g ≥98% Career Henan Chemical Co

77128-69-9 (Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2) Related Search:

SUBSTANCE P Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 Pyr-Gln-Phe-Phe-Gly-Leu-Met-NH2 Substance P (5-11) Substance P (6-11)
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GLP-GLN-PHE-(NME)PHE-SAR-LEU-MET-NH2 [GLP5,(ME)PHE8,SAR9] SUBSTANCE P (5-11) (PYR5,N-ME-PHE8,SAR9)-SUBSTANCE P (5-11) SUBSTANCE P [PGLU5, N-ME-PHE8, SAR9]-FRAGMENT 5-11 PGLU-GLN-PHE-N-METHYL-PHE-SAR-LEU-MET-NH2 PGLU5,MEPHE8,SAR9-SUBSTANCE P FRAGMENT*5 -11 SUBSTANCE P (PGLU5,MEPHE8,SAR9)-*FRAGMEN T 5-11 [pglu5, n-me-phe8, sar9]-substance p fragment 5-11 substance P (5-11), pGlu(5)-MePhe(8)-MeGly(9)- [pGlu5,MePhe8,Sar9]substance P(5-11) 5-Oxo-L-Pro-L-Gln-L-Phe-N-methyl-L-Phe-N-methyl-Gly-L-Leu-L-Met-NH2 DiMe-C7 pGlu-L-Glu(NH2)-L-Phe-N-Methyl-L-Phe-Sar-L-Leu-L-Met-NH2 Substance P, fragment 5-11, [pGlu5, MePhe8, Sar9] L-Methioninamide, 5-oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl- (9CI) (Pyr 5,N-Me-Phe8, Sar 9)-Substance P (5-11) Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 Glp5, (NMe)Phe8, Sar9] Substance P(5-11) Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-NH2 77128-69-9 C43H61N9O9S C43H61N9O15S Antagonist Biochemicals and Reagents Amino Acids and Peptides BioChemical Peptides Tachykinins