Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>[2H8]-Bendamustine Hydrochloride

[2H8]-Bendamustine Hydrochloride

[2H8]-Bendamustine Hydrochloride Structure
[2H8]-Bendamustine Hydrochloride structure
CAS No.
1185068-23-8
Chemical Name:
[2H8]-Bendamustine Hydrochloride
Synonyms
Bendamustine-d8 HCl;Bendamustine hydrochloride salt;[2H8]-Bendamustine Hydrochloride;[2H8]-Bendamustine hydrochloride salt;Bendamustine-[D8] Hydrochloride (Standard)
CBNumber:
CB58012183
Molecular Formula:
C16H22Cl3N3O2
Molecular Weight:
394.72
MDL Number:
MOL File:
1185068-23-8.mol
Last updated:2025-04-18 09:51:11
Request For Quotation

[2H8]-Bendamustine Hydrochloride price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0375412 Bendamustine-d8 hydrochloride 1185068-23-8 1mg $1007 2026-06-04 Buy
ChemScene CS-0375412 Bendamustine-d8 hydrochloride 1185068-23-8 5mg $2687 2026-06-04 Buy
Product number Packaging Price Buy
CS-0375412 1mg $1007 Buy
CS-0375412 5mg $2687 Buy

[2H8]-Bendamustine Hydrochloride Chemical Properties, Uses, Production

Uses

Bendamustine-d8 (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17. DOI:10.1158/1078-0432.CCR-07-1061
[3] Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17. DOI:10.1016/j.cellsig.2013.01.020
[4] Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167(4):881-91. DOI:10.1111/j.1476-5381.2012.02048.x

[2H8]-Bendamustine Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

[2H8]-Bendamustine Hydrochloride Suppliers

Global Suppliers ( 7)
Supplier Tel Email Country ProdList Advantage
Manhag Testing Technology Co., Ltd 400-818 0104 18918165978 yanyan.guo@bestown.net.cn China 7770 58
Hubei YoungXin Pharmaceutical Tech Co.,Ltd. 0714-3999001 19171453112 2881391661@qq.com China 10000 58
TLC Pharmaceutical Standards Ltd. 18012923235 chinasales04@tlcstandards.com.cn China 8301 58
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
Supplier Advantage
Manhag Testing Technology Co., Ltd 58
Hubei YoungXin Pharmaceutical Tech Co.,Ltd. 58
TLC Pharmaceutical Standards Ltd. 58
TargetMol 58

1185068-23-8 ([2H8]-Bendamustine Hydrochloride) Related Search:

5-[(2-Chloroethyl)(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic Acid 1-Methylethyl Ester 4-[-((-((4-(5-(Bis(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoyl)oxy)ethyl)(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanic Acid N1-Methylbenzene-1,2,4-triaMine Bendamustine Deschloro Dimer Impurity 5-[Bis(2-chloroethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Methyl Ester
5-[(2-Chloroethyl)(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Ethyl Ester Bendamustine Related Impurity 9 Bendamustine Related Impurity 22 BendaMustine DiMer 2'-Allyl Ester Bendamustine o-mannitol Ester
Bendamustine-D-Mannose Adduct Bendamustine Related Impurity 3 Bendamustine Related Impurity 12 Bendamustine Related Impurity 8 Bendamustine Related Impurity 21
Bendamustine Related Impurity 19 Bendamustine Related Impurity 6 (Mixture of Isomers) BendaMustine Dideschloroethyl

1of4

[2H8]-Bendamustine Hydrochloride [2H8]-Bendamustine hydrochloride salt Bendamustine-d8 HCl Bendamustine hydrochloride salt Bendamustine-[D8] Hydrochloride (Standard) 1185068-23-8