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ChemicalBook >> CAS DataBase List >>Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)-

Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)-

Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)- Structure
Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)- structure
CAS No.
2374971-81-8
Chemical Name:
Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)-
Synonyms
CPI-1612;(R)-2-(((S)-2-(4-Cyanophenyl)propyl)amino)-N-(5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)-2-phenylacetamide;Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)-
CBNumber:
CB58096099
Molecular Formula:
C27H26N6O
Molecular Weight:
450.55
MDL Number:
MFCD32899894
MOL File:
2374971-81-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-22 18:57:36
Request For Quotation

Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)- Properties

Boiling point 719.1±60.0 °C(Predicted)
Density 1.20±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (221.96 mM; Need ultrasonic)
form Solid
pka 12.12±0.70(Predicted)
color White to off-white

Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth BC177710 CPI-1612 2374971-81-8 1mg $254.1 2026-06-04 Buy
Biosynth BC177710 CPI-1612 2374971-81-8 5mg $1079.95 2026-06-04 Buy
Biosynth BC177710 CPI-1612 2374971-81-8 10mg $1727.9 2026-06-04 Buy
ChemScene CS-0127588 CPI-1612 99.75% 2374971-81-8 5mg $433 2026-06-04 Buy
ChemScene CS-0127588 CPI-1612 99.75% 2374971-81-8 10mg $737 2026-06-04 Buy
Product number Packaging Price Buy
BC177710 1mg $254.1 Buy
BC177710 5mg $1079.95 Buy
BC177710 10mg $1727.9 Buy
CS-0127588 5mg $433 Buy
CS-0127588 10mg $737 Buy

Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)- Chemical Properties, Uses, Production

Uses

CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC50 of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity[1].

in vivo

CPI-1612 (compound 17; 0.5 mg/kg; oral administration; twice a day; for 4 weeks) treatment shows 67% tumor growth inhibition (TGI) with concomitant reduction of H3K27Ac in plasma and reduction of H3K18Ac in the tumor[1].
While the oral exposure of CPI-1612 (compound 17) in dogs (0.5 mg/kg IV; 1.0 mg/kg PO; clearance = 0.42 L/h/kg, Vss = 3.7 L/kg, T1/2 = 5.5 h, F% = 71; AUC/dose = 1691 h·mg/mL) and mice (1 mg/kg IV; 5 mg/kg PO; clearance = 3.8 L/h/kg, Vss = 2.0 L/kg, T1/2 = 0.98 h, F% = 79; AUC/dose = 211 h·mg/mL) is good, the exposure in rats is limited by poor bioavailability (1.0 mg/kg IV; 5.0 mg/kg PO; clearance = 2.6 L/h/kg, Vss = 1.8 L/kg, T1/2 = 1.2 h, F% = 9; AUC/dose = 35.6 h·mg/mL)[1].
A single dose of CPI-1612 is administered orally to CD-1 mice and brain and plasma exposures of CPI-1612 are measured at 0.25, 0.5, 1.0, 2.0, 4.0, and 8.0 h. CPI-1612 is highly brain-penetrant, showing a brain-to-plasma ratio of 0.35 after a single oral dose[1].

Animal Model:C57B6 mice injected with JEKO-1 cells[1]
Dosage:0.5 mg/kg
Administration:Oral administration; twice a day; for 4 weeks
Result:Showed 67% tumor growth inhibition (TGI) at a dose of 0.5 mg/kg.

IC 50

CBP/p300

References

[1] Jonathan E Wilson, et al. Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor. ACS Med Chem Lett. 2020 Apr 23;11(6):1324-1329. DOI:10.1021/acsmedchemlett.0c00155

Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)- Suppliers

Global Suppliers ( 15)
Supplier Tel Email Country ProdList Advantage
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4565 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 024-88590548 18698872706 757984502@qq.com China 960 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5985 58
Soochow Chirally Material Science and Technology Co.,Ltd 0512-66834346 17751187418 sales@krl-tech.com China 1284 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9831 58
Aikon International Limited 025-58859352 18651614124 2881516338@qq.com China 9968 58
Soochow Chirally Material Science and Technology Co.,Ltd +86-51266834346 +86-17751128648 sales@krl-tech.com China 1050 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Beijing Solarbio Science & Tecnology Co., Ltd. 68
ShangHai ChuanQian Chemcial Technique Centre 58
TargetMol Chemicals Inc. 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58
Nantong QuanYi Biotechnology Co., Ltd 58
Soochow Chirally Material Science and Technology Co.,Ltd 58
RD International Technology Co., Limited 58
Aikon International Limited 58
Soochow Chirally Material Science and Technology Co.,Ltd 58
TargetMol Chemicals Inc. 58

View Latest Price from Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)- manufacturers

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CPI-1612 pictures 2026-04-22 CPI-1612
2374971-81-8
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    2374971-81-8
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2374971-81-8 (Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)-) Related Search:

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Benzeneacetamide, α-[[(2S)-2-(4-cyanophenyl)propyl]amino]-N-[5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]-, (αR)- CPI-1612 (R)-2-(((S)-2-(4-Cyanophenyl)propyl)amino)-N-(5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)-2-phenylacetamide 2374971-81-8 C27H26N6O