Polymyxin B nonapeptide TFA
- CAS No.
- 2220175-42-6
- Chemical Name:
- Polymyxin B nonapeptide TFA
- Synonyms
- Polymyxin B nonapeptide TFA;Polymyxin B nonapeptide（TFA salt）;(2S,3R)-2-Amino-N-((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)-3-hydroxybutanamide 2,2,2-trifluoroacetate
- CBNumber:
- CB58205871
- Molecular Formula:
- C45H75F3N14O13
- Molecular Weight:
- 1077.18
- MDL Number:
- MFCD32708539
- MOL File:
- 2220175-42-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Polymyxin B nonapeptide TFA price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | VND17542 | Polymyxin B nonapeptide TFA | 2220175-42-6 | 1mg | $150 | 2026-06-05 | Buy |
| Biosynth | VND17542 | Polymyxin B nonapeptide TFA | 2220175-42-6 | 10mg | $625 | 2026-06-05 | Buy |
| Biosynth | VND17542 | Polymyxin B nonapeptide TFA | 2220175-42-6 | 25mg | $1250 | 2026-06-05 | Buy |
| ChemScene | CS-0128232 | Polymyxin B nonapeptide TFA 99.79% | 2220175-42-6 | 5mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-0128232 | Polymyxin B nonapeptide TFA 99.79% | 2220175-42-6 | 10mg | $271 | 2026-06-04 | Buy |
Polymyxin B nonapeptide TFA Chemical Properties, Uses, Production
Uses
Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[1][2][3].
in vivo
Polymyxin B nonapeptide TFA (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate[2].
References
[1] Al-Marzooq F, et al. Discerning the role of polymyxin B nonapeptide in restoring the antibacterial activity of azithromycin against antibiotic-resistant Escherichia coli. Front Microbiol. 2022 Sep 21;13:998671. DOI:10.3389/fmicb.2022.998671
[2] Danner RL,et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother. 1989 Sep;33(9):1428-34. DOI:10.1128/AAC.33.9.1428
[3] Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7. DOI:10.1128/AAC.38.2.374
Polymyxin B nonapeptide TFA Preparation Products And Raw materials
Raw materials
Preparation Products
Polymyxin B nonapeptide TFA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Zhengzhou Huiju Chemical Co., Ltd. | 0371-55900031 18137872243 | 3927209986@qq.com | China | 9999 | 55 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Nanchang Tianzhen Biotechnology Co., Ltd | 13758194781 13173652190 | 522013271@qq.com | China | 2436 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2377 | 58 |
