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| | Polymyxin B nonapeptide TFA Basic information |
| Product Name: | Polymyxin B nonapeptide TFA | | Synonyms: | Polymyxin B nonapeptide TFA;(2S,3R)-2-Amino-N-((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)-3-hydroxybutanamide 2,2,2-trifluoroacetate;Polymyxin B nonapeptide（TFA salt） | | CAS: | 2220175-42-6 | | MF: | C45H75F3N14O13 | | MW: | 1077.18 | | EINECS: | | | Product Categories: | | | Mol File: | 2220175-42-6.mol |  |
| | Polymyxin B nonapeptide TFA Chemical Properties |
| storage temp. | Store at -20°C,protect from light | | form | Solid | | color | White to off-white | | Water Solubility | Water: 100 mg/mL (65.22 mM) | | Sequence | Thr-{Dab}-{Dab}-{Dab}-{d-Phe}-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9) |
| | Polymyxin B nonapeptide TFA Usage And Synthesis |
| Uses | Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[1][2][3]. | | in vivo | Polymyxin B nonapeptide TFA (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate[2].
| | References | [1] Al-Marzooq F, et al. Discerning the role of polymyxin B nonapeptide in restoring the antibacterial activity of azithromycin against antibiotic-resistant Escherichia coli. Front Microbiol. 2022 Sep 21;13:998671. DOI:10.3389/fmicb.2022.998671
[2] Danner RL,et al. Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide. Antimicrob Agents Chemother. 1989 Sep;33(9):1428-34. DOI:10.1128/AAC.33.9.1428
[3] Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7. DOI:10.1128/AAC.38.2.374 |
| | Polymyxin B nonapeptide TFA Preparation Products And Raw materials |
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