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A 71623

A 71623 Structure
A 71623 structure
CAS No.
130408-77-4
Chemical Name:
A 71623
Synonyms
A 71623;A-71623 TFA;N-Boc-L-Trp-[(2S)-2-Amino*-6-[3-(2-methylphenyl)ureido]hexanoyl]-L-Asp-N-methyl-L-Phe-NH2;N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-L-phenylalaninamide;L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-;N-[(1,1-DIMETHYLETHOXY)CARBONYL]-L-TRYPTOPHYL-N6-[[(2-METHYLPHENYL)AMINO]CARBONYL]-L-LYSYL-L-ALPHA-ASPARTYL-NA-METHYL-L-PHENYLALANINAMIDE
CBNumber:
CB5829349
Molecular Formula:
C44H56N8O9
Molecular Weight:
840.97
MDL Number:
MFCD00897724
MOL File:
130408-77-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-28 08:09:06
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A 71623 Properties

Boiling point 1126.589±65.00 °C(Press: 760.00 Torr)(predicted)
Density 1.287±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Desiccate at -20°C
solubility Soluble to 1 mg/ml in 20mM PBS buffer
form solid
pka 4.383±0.10(predicted)
color White

A 71623 price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 254494 A-71623 Asreported 130408-77-4 1mg $573 2026-06-03 Buy
ChemScene CS-0027708 A71623 99.34% 130408-77-4 1mg $320 2026-06-04 Buy
ChemScene CS-0027708 A71623 99.34% 130408-77-4 5mg $959 2026-06-04 Buy
ChemScene CS-0027708 A71623 99.34% 130408-77-4 10mg $1517 2026-06-04 Buy
ApexBio Technology B7046 A-71623 130408-77-4 1mg $400 2026-05-06 Buy
Product number Packaging Price Buy
254494 1mg $573 Buy
CS-0027708 1mg $320 Buy
CS-0027708 5mg $959 Buy
CS-0027708 10mg $1517 Buy
B7046 1mg $400 Buy

A 71623 Chemical Properties, Uses, Production

Uses

A-71623 is a potent CCK agonist with 1200-fold selectivity over the CCK2 receptor.

Biological Activity

Potent CCK 1 agonist (IC 50 = 3.7 nM) with 1200-fold selectivity over the CCK 2 receptor. Suppresses food intake following central or peripheral administration.

in vivo

A71623 (A-63387; i.c.v., but not i.p., injections) reduces food intakes and suppresses intakes of a liquid diet in both deprived and sated rats[2].
A71623 dampens Purkinje neuron pathology and associates deficits in motor performance in Pcp2-ATXN1[30Q]D776;Cck-/- and Pcp2-AXTN1[82Q] mice[3].
A71623 improves motor performance of Pcp2-ATXN2[127Q] SCA2 mice[3].

Animal Model:Adult male, Sprague-Dawley rats[2]
Dosage:5 μL
Administration:Intracerebroventricular (i.c.v) administration, A-71623 was infused using a 28 gauge injection cannula in a volume of 5uL over 60 s
Result:Reduced food intakes and suppressed intakes of a liquid diet.
Animal Model:ATXN1[30Q]-D776, ATXN1[82Q]-D776, ATXN2[127Q], and WT/FVB/NJ mice [3]
Dosage:0.02 mg/kg/day
Administration:Osmotic minipumps containing either A71623 (0.02mg/kg/day) were implanted intraperitoneally (i.p.)
Result:Treatment dampened Purkinje neuron pathology in ATXN1[30Q]D776;Cck-/- mice and ATXN1[82Q] mice.
Improved motor performance in ATXN2[127Q] mice.

IC 50

CCKAR

storage

Store at -20°C

References

[1]. gracey dj, bell r, king dj. differential effects of the ccka receptor ligands pd-140,548 and a-71623 on latent inhibition in the rat. progress in neuro-psychopharmacology and biological psychiatry, 2002, 26(3): 497-504.
[2]. lin cw, shiosaki k, miller tr, et al. characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, a-71623 and a-70874, that exhibit high potency and selectivity for cholecystokinin-a receptors. molecular pharmacology, 1991, 39(3): 346-351.
[3]. kaufmann r, lindschau c, scho t, et al. type b cholecystokinin receptors on rat glioma c6 cells. binding studies and measurement of intracellular calcium mobilization. brain research, 1994, 639(1): 109-114.

A 71623 Preparation Products And Raw materials

Raw materials

Preparation Products

A 71623 Suppliers

Global Suppliers ( 34)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Shanghai YuanYe Biotechnology Co., Ltd. 18916372613 yanzihan@shyuanye.com China 87240 60
Chengdu Youngshe Chemical Co., Ltd. +86-17380623303 Caroline@youngshechem.com China 4730 58
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919 15967184799 Eric@peptidego.com China 7892 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 sales@sarms4muscle.com China 10378 58
Wuxi Helen Biotechnology Co., Ltd., 0510-85629785 18013409632 sales@reading-chemicals.com China 14072 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 43066 58
Shanghai Universal Biotech Co.,Ltd 15921930842 15921930842 yh-wang@univ-bio.com China 25030 58
Shaoxing Junyu Biotechnology Co., LTD 0571-0571-88211921 19105816207 sales4@gotopbio.com China 5135 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Shanghai YuanYe Biotechnology Co., Ltd. 60
Chengdu Youngshe Chemical Co., Ltd. 58
Hangzhou Peptidego Biotech Co.,Ltd. 58
BOC Sciences 58
Zhejiang J&C Biological Technology Co.,Limited 58
Wuxi Helen Biotechnology Co., Ltd., 58
Energy Chemical 58
Shanghai Universal Biotech Co.,Ltd 58
Shaoxing Junyu Biotechnology Co., LTD 58

130408-77-4 (A 71623) Related Search:

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N-[(1,1-DIMETHYLETHOXY)CARBONYL]-L-TRYPTOPHYL-N6-[[(2-METHYLPHENYL)AMINO]CARBONYL]-L-LYSYL-L-ALPHA-ASPARTYL-NA-METHYL-L-PHENYLALANINAMIDE N-Boc-L-Trp-[(2S)-2-Amino*-6-[3-(2-methylphenyl)ureido]hexanoyl]-L-Asp-N-methyl-L-Phe-NH2 N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-L-phenylalaninamide A 71623 L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl- A-71623 TFA 130408-77-4 C44H56N8O9