1-Methyl-1H-benzoimidazol-5-ylamine trihydrochloride
- CAS No.
- 10394-38-4
- Chemical Name:
- 1-Methyl-1H-benzoimidazol-5-ylamine trihydrochloride
- Synonyms
- 1-methyl-1H-benzimidazol-5-amine;NSC 240760;1-Methylbenzimidazol-5-amine;1-Methyl-5-aminobenzimidazole;1-Methylbenzoimidazol-5-amine;5-Amino-1-methylbenzimidazole;1-methylbenzimidazole-5-amine;5-Amino-1-methyl-1H-benzimidazole;5-Amino-1-methylbenzimidazole,97%;1-Methyl-1H-1,3-benzodiazol-5-aMine
- CBNumber:
- CB5835122
- Molecular Formula:
- C8H9N3
- Molecular Weight:
- 147.18
- MDL Number:
- MFCD03164349
- MOL File:
- 10394-38-4.mol
- MSDS File:
- SDS
| Melting point | 158-159 °C |
|---|---|
| Boiling point | 348.6±34.0 °C(Predicted) |
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | Solid |
| pka | 6.35±0.10(Predicted) |
| Appearance | Light brown to black Solid |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
1-Methyl-1H-benzoimidazol-5-ylamine trihydrochloride price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS36507 | 1-Methylbenzoimidazol-5-amine 97% | 10394-38-4 | 1g | $80 | 2026-06-04 | Buy |
| Activate Scientific | AS36507 | 1-Methylbenzoimidazol-5-amine 97% | 10394-38-4 | 5g | $288 | 2026-06-04 | Buy |
| Activate Scientific | AS36507 | 1-Methylbenzoimidazol-5-amine 97% | 10394-38-4 | 25g | $1055 | 2026-06-04 | Buy |
| Matrix Scientific | 076429 | 1-Methylbenzoimidazol-5-amine | 10394-38-4 | 250.00mg | $278 | 2026-05-18 | Buy |
| Matrix Scientific | 076429 | 1-Methylbenzoimidazol-5-amine | 10394-38-4 | 1.00g | $599 | 2026-05-18 | Buy |
1-Methyl-1H-benzoimidazol-5-ylamine trihydrochloride Chemical Properties, Uses, Production
Uses
1-Methyl-5-aminobenzimidazole is used in the synthesis of usnic acid derivatives as tau-aggregation and neuroinflammation inhibitor.
Synthesis
5381-78-2
10394-38-4
Example B23: 1-methyl-5-nitro-1H-benzo[d]imidazole (prepared according to the method described in WO 2005/092899; 1.14 g, 6.43 mmol) was dissolved in ethanol (50 ml) and stirred at room temperature under hydrogen (1 atm) atmosphere. 10% Pd/C catalyst (50 wt% water, 1.37 g, 0.643 mmol) was added. After 18 h of reaction, the reaction mixture was filtered through diatomaceous earth and rinsed with ethanol. The filtrates were combined and concentrated to afford the crude product 1-methyl-1H-benzo[d]imidazol-5-amine (1.02 g, 108% yield) as a dark orange oil, which was used directly in the next step of the reaction.1H NMR (400 MHz, DMSO-d6) δ 7.87 (s, 1H), 7.17 (d, J=8.4 Hz, 1H), 6.75 (d, J=2.0 Hz, 1H), 6.59 (dd, J=2.0 and 8.4 Hz, 1H), 4.73 (brs, 2H), 3.69 (s, 3H); MS (ESI) m/z: 148.0 (M+H+). Using a method similar to Example B22, 1-methyl-1H-benzo[d]imidazol-5-amine (0.50 g, 3.4 mmol), NaNO2 (0.28 g, 4.1 mmol), SnCl2-2H2O (2.8 g, 14 mmol), and 4-methyl-3-oxopentanenitrile (0.45 g, 4.1 mmol) were reacted to give the crude product 3-Isopropyl-1-(1-methyl-1H-benzo[d]imidazol-5-yl)-1H-pyrazol-5-amine (0.63 g, 73% yield), as a foam, was used directly in the next step of the reaction.1H NMR (400 MHz, DMSO-d6): δ 8.22 (s, 1H), 7.72 (dd, J=0.40 and 1.2 Hz, 1H), and 7.60 (dd, J=0.40 and 8.4 Hz, 1H), 7.42 (dd, J=2.0 and 8.4 Hz, 1H), 5.32 (s, 1H), 5.08 (brs, 2H), 3.85 (s, 3H), 2.75 (septet, J=6.8 Hz, 1H), 1.16 (d, J=6.8 Hz, 6H); MS ( ESI) m/z: 250.0 (M+H+).
References
[1] Patent: US2008/90856, 2008, A1. Location in patent: Page/Page column 46-47
[2] Patent: US2007/27184, 2007, A1. Location in patent: Page/Page column 20
[3] Journal of Pharmacy and Pharmacology, 1951, vol. 3, p. 420,424
[4] Gazzetta Chimica Italiana, 1955, vol. 85, p. 981,984
[5] Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 3, p. 713 - 724
1-Methyl-1H-benzoimidazol-5-ylamine trihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1-Methyl-1H-benzoimidazol-5-ylamine trihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Acorn PharmaTech Co., Ltd. | 025-58395930 | sales@acornpharma.com | China | 982 | 60 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1784 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Porse Fine Chemical Co.,LTD | 20-66003216 18666003216 | info@porsefinechemical.com | China | 1963 | 62 |
| Suzhou Laing Biological Technology Co., LTD | 0512-62968256 18550502935 | export@laingbiotec.com | China | 994 | 58 |
View Latest Price from 1-Methyl-1H-benzoimidazol-5-ylamine trihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-23 | 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE
10394-38-4
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE
10394-38-4
- $1.00
- 99%
- Career Henan Chemical Co
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