2,6-Dichlorothiobenzamide
- CAS No.
- 1918-13-4
- Chemical Name:
- 2,6-Dichlorothiobenzamide
- Synonyms
- CHLORTHIAMID;dcbn;sd7961;prefix;Prefix[R];chlortiamid;chlorthiami;chlorthiamide;CHLOROTHIAMID;chlorthioamide
- CBNumber:
- CB5853270
- Molecular Formula:
- C7H5Cl2NS
- Molecular Weight:
- 206.09
- MDL Number:
- MFCD00053523
- MOL File:
- 1918-13-4.mol
- MSDS File:
- SDS
| Melting point | 151-152°C |
|---|---|
| Boiling point | 320.6±52.0 °C(Predicted) |
| Density | 1.4704 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| Flash point | >100 °C |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 11.71±0.29(Predicted) |
| color | White to Pale Beige |
| Water Solubility | 0.95g/L(21 ºC) |
| BRN | 1910353 |
| Henry's Law Constant | 3.5×104 mol/(m3Pa) at 25℃, MacBean (2012) |
| CAS DataBase Reference | 1918-13-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 5JVN5HGD7S |
| EPA Substance Registry System | Chlorthiamid (1918-13-4) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | CV3850000 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2930909899 | |||||||||
| Toxicity | LD50 oral in rabbit: 300mg/kg | |||||||||
| NFPA 704 |
|
2,6-Dichlorothiobenzamide price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 45398 | Chlorthiamid PESTANAL?, analytical standard | 1918-13-4 | 100mg | $57.1 | 2026-04-30 | Buy |
| TRC | TRC-C369943-250MG | Chlorthiamid | 1918-13-4 | 250mg | $79 | 2026-06-03 | Buy |
| TRC | TRC-C369943-100MG | Chlorthiamid | 1918-13-4 | 100mg | $64 | 2026-06-03 | Buy |
| ChemScene | CS-0091868 | Chlorthiamid ≥98% | 1918-13-4 | 10mg | $27 | 2026-06-04 | Buy |
| ChemScene | CS-0091868 | Chlorthiamid ≥98% | 1918-13-4 | 25mg | $43 | 2026-06-04 | Buy |
2,6-Dichlorothiobenzamide Chemical Properties, Uses, Production
Description
Chlorthiamid is an obsolete pre-emergence herbicide once used for non-selective weed control. It is moderate soluble in water and is non-volatile. It is not persistent in soil systems and considered to be moderately mobile, and so it may leach to groundwater under certain conditions. Its toxicity to flora and fauma tends to be low to moderate. It also has a low mammalian toxicity. Little information is available on chlorthiamids potential for serious adverse health effects.
Uses
Refer to the productμs Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Definition
ChEBI: 2,6-dichlorothiobenzamide is a dichlorobenzene and a thiocarboxamide. It has a role as a proherbicide and an agrochemical.
Production Methods
Chlorthiamid is produced commercially through a synthesis involving chlorinated aromatic compounds and thiourea chemistry. The process typically begins with the chlorination of benzene derivatives to form 2,6-dichlorobenzoyl chloride, which is then reacted with ammonium thiocyanate or similar sulphur-containing reagents to introduce the thioamide functional group. This reaction yields the active compound, chlorthiamid, under controlled temperature and solvent conditions to ensure purity and yield. Once synthesised, the product is purified and formulated.
Mechanism of action
Systemic, absorbed by roots and leaves, acting against germinating seeds. Inhibits cell wall synthesis
Safety Profile
Poison by ingestion and intraperitoneal route. Moderately toxic by skin contact. Mutation data reported. An herbicide. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and sox.
Metabolic pathway
Twelve metabolites are isolated from either urine or
bile from either rats (11 metabolites) or goats (seven
metabolites) given single oral doses of 14C-labeled
2,6-dichlorobenzonitrile (DCBN). Five of these
metabolites are also excreted in urine from rats dosed
orally with 2,6-dichlorothiobenzamide (DCTBA) which
is an acid amide analog. All metabolites from either DCBN or DCTBA are benzonitriles with the following
ring substituents: Cl2, OH (three isomers); Cl2, (OH)2;
Cl, (OH)2; Cl, OH, SH; Cl, OH, SCH3; SOCH3, OH;
Cl2, S-(N-acetyl)cysteine; Cl, S-(N-acetyl)cysteine; Cl,
OH, S-(N-acetyl)cysteine.
The thiobenzamide moiety of DCTBA is converted
to the nitrile in all extracted urinary metabolites. No
hydrolysis of the nitrile in DCBN to either amide or an
acid is detected. Urine is the major route for excretion;
however, enterohepatic circulation occurs.
Pesticide Type
Herbicide
2,6-Dichlorothiobenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Beijing FYF Chemicals Co., Ltd | 010-57903446 15869909019 | 168931144@qq.com | China | 2876 | 58 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4508 | 55 |
| Wuhan Chemwish Technology Co.， Ltd | 027-67849912 | sales@chemwish.com | China | 9144 | 60 |
