QD-394
- CAS No.
- 2132411-21-1
- Chemical Name:
- QD-394
- Synonyms
- QD-394;QD 394,QD394;6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-5,8-quinazolinedione;5,8-Quinazolinedione, 6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-
- CBNumber:
- CB59739308
- Molecular Formula:
- C19H19N5O2
- Molecular Weight:
- 349.39
- MDL Number:
- MOL File:
- 2132411-21-1.mol
- MSDS File:
- SDS
| Boiling point | 566.3±50.0 °C(Predicted) |
|---|---|
| Density | 1.368±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMF: 1 mg/lm,DMSO: 5 mg/ml,DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml,Ethanol: 1 mg/lm,PBS (pH 7.2): slightly soluble |
| form | A crystalline solid |
| pka | 7.92±0.42(Predicted) |
| color | Brown to black |
QD-394 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 31769 | QD-394 ≥98% | 2132411-21-1 | 1mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 31769 | QD-394 ≥98% | 2132411-21-1 | 5mg | $250 | 2026-04-30 | Buy |
| Cayman Chemical | 31769 | QD-394 ≥98% | 2132411-21-1 | 10mg | $470 | 2026-04-30 | Buy |
| Cayman Chemical | 31769 | QD-394 ≥98% | 2132411-21-1 | 25mg | $976 | 2026-04-30 | Buy |
| Biosynth | HKD41121 | 6-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]-5,8-quinazolinedione | 2132411-21-1 | 25mg | $1164.25 | 2026-06-04 | Buy |
QD-394 Chemical Properties, Uses, Production
Uses
QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis[1].
Biological Activity
QD-394 is an inducer of reactive oxygen species (ROS) production.1 It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.
References
1.Hu, S., Sechi, M., Singh, P.K., et al.A novel redox modulator induces a GPX4-mediated cell death that is dependent on iron and reactive oxygen speciesJ. Med. Chem.63(17)9838-9855(2020)
QD-394 Preparation Products And Raw materials
Raw materials
Preparation Products
QD-394 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 0571-89903022 18679456698 | zilong@hizyme.com | China | 7853 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 10000 | 58 |
