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Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester

Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester structure

CAS No.: 1429218-54-1

Chemical Name:: Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester

Synonyms: Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester

CBNumber:: CB59760056

Molecular Formula:: C21H29N3O5

Molecular Weight:: 403.47

MDL Number:

MOL File:: 1429218-54-1.mol

MSDS File:: SDS

Last updated:2025-04-18 09:51:14

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Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester Properties

Boiling point	680.6±50.0 °C(Predicted)
Density	1.170±0.06 g/cm3(Predicted)
pka	11.13±0.46(Predicted)

Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester Chemical Properties, Uses, Production

Description

GC373 is a novel broad-spectrum antiviral against 3c or 3c-like proteases of picornaviruses, noroviruses, and coronaviruses

Uses

GC373 is a potent inhibitor of SARS-CoV-2 Mpro that blocks virus replication with an IC50 of 0.4 μM. CG373 can be utilized in anti-COVID-19 research[1].

References

[1] Vuong W, et al. Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies. Eur J Med Chem. 2021 Oct 15;222:113584. DOI:10.1016/j.ejmech.2021.113584

Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

Carbamic acid, N-[(1S)-1-[[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester 1429218-54-1