AG 957
- CAS No.
- 140674-76-6
- Chemical Name:
- AG 957
- Synonyms
- AG 957;NSC 654705;TYRPHOSTIN 957;TYRPHOSTIN AG 957;LAVENDUSTIN C ANALOG;AG957, 10 mM in DMSO;Methyl 4-((2,5-dihydroxybenzyl)amino)benzoate;4-AMINO-N-(2,5-DIHYDROXYBENZYL)METHYL BENZOATE;Tyrphostin AG 957, p210 tyrosine kinase inhibitor;METHYL-4-[N-(2',5'-DIHYDROXYBENZYL)AMINO]BENZOATE
- CBNumber:
- CB6100142
- Molecular Formula:
- C15H15NO4
- Molecular Weight:
- 273.28
- MDL Number:
- MFCD01074970
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| AG957 ≥98% | 17259 | 1mg | $41 |
| AG957 ≥98% | 17259 | 5mg | $128 |
| AG957 ≥98% | 17259 | 10mg | $235 |
| AG957 99.30% | CS-0067002 | 5mg | $157 |
| AG957 99.30% | CS-0067002 | 10mg | $251 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
AG 957 price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17259 | AG957 ≥98% | 140674-76-6 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 17259 | AG957 ≥98% | 140674-76-6 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 17259 | AG957 ≥98% | 140674-76-6 | 10mg | $235 | 2026-04-30 | Buy |
| ChemScene | CS-0067002 | AG957 99.30% | 140674-76-6 | 5mg | $157 | 2026-06-04 | Buy |
| ChemScene | CS-0067002 | AG957 99.30% | 140674-76-6 | 10mg | $251 | 2026-06-04 | Buy |
AG 957 Chemical Properties,Uses,Production
Description
Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases. AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185Bcr-Abl, p210Bcr-Abl), as well as normal c-Abl (IC50s = 4.3, 1, and 7.1 μM, respectively, for human proteins). It also inhibits epidermal growth factor receptor (IC50 = 0.25 μM). As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line. AG957 is also used to study signaling through c-Abl.
Uses
Tyrphostin AG 957 is a potent tyrosine kinase inhibitor. Also, it causes metabolic alterations in K562 cells. It is a COVID19-related research product.
Definition
ChEBI: 4-[(2,5-dihydroxyphenyl)methylamino]benzoic acid methyl ester is an aromatic amine.
in vivo
AG957 (10 mg/kg; intratracheally 1 h before intratracheal LPS challenge) blocks c-Abl activity in the lung of mice[4].
| Animal Model: | C57BL/6J mice[4] |
| Dosage: | 10 mg/kg |
| Administration: | Intratracheally 1 h before intratracheal LPS challenge |
| Result: | LPS induced significant phosphorylation of paxillin at Y31 and Y118. Inhibition of c-Abl by AG957 attenuated LPS-induced phosphorylation of paxillin at both sites. LPS induced significant phosphorylation of VE-cadherin in DMSO-treated mice, which was attenuated in AG957-treated mice. |
References
[1]. anafi m, gazit a, gilon c, et al. selective interactions of transforming and normal abl proteins with atp, tyrosine-copolymer substrates, and tyrphostins. j biol chem. 1992 mar 5;267(7):4518-23.
[2]. kaur g, gazit a, levitzki a, et al. tyrphostin induced growth inhibition: correlation with effect on p210bcr-abl autokinase activity in k562 chronic myelogenous leukemia. anticancer drugs. 1994 apr;5(2):213-22.
[3]. jamieson l, carpenter l, biden tj, et al. protein kinase ciota activity is necessary for bcr-abl-mediated resistance to drug-induced apoptosis. j biol chem. 1999 feb 12;274(7):3927-30.
[4]. fu p, usatyuk pv, lele a, et al. c-abl mediated tyrosine phosphorylation of paxillin regulates lps-induced endothelial dysfunction and lung injury. am j physiol lung cell mol physiol. 2015 may 15;308(10):l1025-38.
AG 957 Preparation Products And Raw materials
Raw materials
Preparation Products
AG 957 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Nanjing Moldeep Biochemical Co., Ltd. | +86-25-58282389 +86-17351037455 | inquiries@moldeep.com | China | 19999 | 58 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai CR Corporation Limited | 13062833949; 13062833949 | fred.wen@crcorporation.cn | China | 9792 | 58 |
