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ChemicalBook >> CAS DataBase List >>1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]-

1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]-

1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]- Structure
1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]- structure
CAS No.
2756566-45-5
Chemical Name:
1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]-
Synonyms
UZH2;4-{4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-difluorophenyl}-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one;1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]-
CBNumber:
CB610510425
Molecular Formula:
C27H37F2N7O
Molecular Weight:
513.63
MDL Number:
MOL File:
2756566-45-5.mol
Last updated:2025-10-04 09:42:42
Request For Quotation

1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]- Properties

Boiling point 724.9±60.0 °C(Predicted)
Density 1.29±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka 14.26±0.20(Predicted)
color White to off-white
InChIKey GYWOVBUGFWWSJR-UHFFFAOYSA-N
SMILES O=C1CN(C2C=C(F)C(CN3CCC(C)(C)CC3)=CC=2F)CC2(CCN(C3=NC=NC(NC)=C3)CC2)N1

1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]- Chemical Properties,Uses,Production

Uses

UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM.

Biological Activity

UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM.

References

[1]. Dolbois A, et al. 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J Med Chem. 2021 Sep 9;64(17):12738-12760.

1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]- Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
Wuhan Acumen Bio-Technology Co.,ltd 027-027-16602739303 16602739303 673003916@qq.com China 2965 58
Beijing HwrkChemical Technology Co., Ltd 18515581800 18501085097 sales.bj@hwrkchemical.com China 9399 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3503 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2957 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62320 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24989 58
Henan Alpha Chemical Co., Ltd. 0371-55013243 15324716602 2853979810@qq.com China 9964 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Wuhan Acumen Bio-Technology Co.,ltd 58
Beijing HwrkChemical Technology Co., Ltd 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Rechem science Co., Ltd. 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Henan Alpha Chemical Co., Ltd. 58

View Lastest Price from 1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
UZH2 pictures 2025-10-03 UZH2
2756566-45-5
 US $123.00-496.00 / mg 99.89% 10g TargetMol Chemicals Inc.
  • UZH2 pictures
  • UZH2
    2756566-45-5
  • US $123.00-496.00 / mg
  • 99.89%
  • TargetMol Chemicals Inc.

1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]- Spectrum

INDEX NAME NOT YET ASSIGNED(2756566-45-5)1HNMR
UZH2 4-{4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-difluorophenyl}-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one 1,4,9-Triazaspiro[5.5]undecan-2-one, 4-[4-[(4,4-dimethyl-1-piperidinyl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)-4-pyrimidinyl]- 2756566-45-5 C27H37F2N7O