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Calpain Inhibitor I

Calpain Inhibitor I structure

CAS No.: 110044-82-1

Chemical Name:: Calpain Inhibitor I

Synonyms: LLNL;ALLN;MG 101;ac-llnl-cho;MG-101 (ALLN);InSolution? ALLN;CALPAIN INHIBITOR;AC-LL-NORLEUCINAL;Ac-Leu-Leu-Nle-al;AC-LEU-LEU-NLE-CHO

CBNumber:: CB6108214

Molecular Formula:: C20H37N3O4

Molecular Weight:: 383.53

MDL Number:: MFCD00065505

MOL File:: 110044-82-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
ALLN	208719	5mg	$128
ALLN	208719	25mg	$335
Calpain Inhibitor I N-Acetyl-Leu-Leu-norleucinal,synthetic	11086090001	25mg	$374
Calpain Inhibitor I ≥95%	14921	1mg	$35
Calpain Inhibitor I ≥95%	14921	5mg	$68

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Calpain Inhibitor I Properties

Melting point	182 °C
Boiling point	510.42°C (rough estimate)
Density	1.1322 (rough estimate)
refractive index	1.6300 (estimate)
storage temp.	2-8°C
solubility	DMSO: soluble
form	powder
pka	13.53±0.46(Predicted)
color	white
biological source	synthetic (organic)
Water Solubility	Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.
BRN	7656053
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChI	1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
InChIKey	FMYKJLXRRQTBOR-BZSNNMDCSA-N
SMILES	[H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
UNSPSC Code	12352204
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P271-P280
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	3
F	3-10
HS Code	29241900
Storage Class	11 - Combustible Solids

Calpain Inhibitor I price More Price(65)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	208719	ALLN	110044-82-1	5mg	$128	2026-04-30	Buy
Sigma-Aldrich	208719	ALLN	110044-82-1	25mg	$335	2026-04-30	Buy
Sigma-Aldrich	11086090001	Calpain Inhibitor I N-Acetyl-Leu-Leu-norleucinal,synthetic	110044-82-1	25mg	$374	2026-04-30	Buy
Cayman Chemical	14921	Calpain Inhibitor I ≥95%	110044-82-1	1mg	$35	2026-04-30	Buy
Cayman Chemical	14921	Calpain Inhibitor I ≥95%	110044-82-1	5mg	$68	2026-04-30	Buy

Product number	Packaging	Price	Buy
208719	5mg	$128	Buy
208719	25mg	$335	Buy
11086090001	25mg	$374	Buy
14921	1mg	$35	Buy
14921	5mg	$68	Buy

Calpain Inhibitor I Chemical Properties,Uses,Production

Description

ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1Inhibits cell cycle progression at G1/Sand metaphase/anaphase in CHO cells by inhibiting cyclin B degradation.2Inhibits proteolytic degradation of IκBα and IκBβ in RAW macrophages induced with LPS.3Blocks AIF-mediated necroptosis.4Cell permeable.

Chemical Properties

white to off-white powder

Uses

Calpain inhibitor I reversibly blocks the calcium-dependent neutral cysteine protease calpain I. Calpains have been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation.

Uses

It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Uses

Calpain inhibitor I inhibits calpain, which activates myosin light chain kinase and protein kinase C by partial proteolysis. The inhibitor should be membrane permeable due to low molecular weight and lack of charged residues.
Calpain Inhibitor I is used for western blotting methods.

Definition

ChEBI: A tripeptide composed of N-acetylleucyl, leucyl and norleucinal residues joined in sequence.

General Description

Calpain Inhibitor I is a strong, competitive inhibitor of the Ca²⁺-dependent neutral cysteine proteases calpain I and calpain II.

Biological Activity

Calpain inhibitor (IC 50 = 0.09 μ M) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro . Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.

Biochem/physiol Actions

Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis. It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL..

References

[1] T SASAKI. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins.[J]. Journal of enzyme inhibition, 1990, 3 3: 195-201. DOI:10.3109/14756369009035837
[2] S W SHERWOOD. In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1993, 90 8: 3353-3357. DOI:10.1073/pnas.90.8.3353
[3] N-acetyl-leucinyl-leucinyl-norleucinal inhibits lipopolysaccharide-induced NF-kappaB activation and prevents TNF and IL-6 synthesis in vivo
[4] LEI SHANG. Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure.[J]. BMC Neuroscience, 2014, 15: 63. DOI:10.1186/1471-2202-15-63

Calpain Inhibitor I Preparation Products And Raw materials

Raw materials

Preparation Products

Calpain Inhibitor I Suppliers

Global( 160)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6288	58
ANHUI WITOP BIOTECH CO., LTD	+8618071025641	eric@witopchemical.com	China	23504	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
Wuhan Han Sheng New Material Technology Co.，Ltd	+86-17798174412	admin01@hsnm.com.cn	China	2082	58
Aladdin Scientific		tp@aladdinsci.com	United States	50108	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53799	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
ANHUI WITOP BIOTECH CO., LTD	58
BOC Sciences	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Wuhan Han Sheng New Material Technology Co.，Ltd	58
Aladdin Scientific	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58

View Lastest Price from Calpain Inhibitor I manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	MG-101 110044-82-1	$48.00-157.00		97.02%	10g	TargetMol Chemicals Inc.

MG-101
110044-82-1
$48.00-157.00
97.02%
TargetMol Chemicals Inc.

Calpain Inhibitor I Spectrum

ALLN(110044-82-1)MS

110044-82-1(Calpain Inhibitor I)Related Search:

Calpain Inhibitor I CALPAIN INHIBITOR III MG-132 CALPAIN INHIBITOR I MET-ALA-GLY-ARG-SER-GLY-ASP-SER-ASP-GLU-ASP-LEU-LEU-LYS-ALA-VAL

(TYR0)-KALIURETIC PEPTIDE (HUMAN) H-PRO-ALA-VAL-ASP-LEU-LEU-LYS-ASN-TYR-MET-GLN-LEU-GLY-LYS-GLN-OH ASP-GLU-ASP-LEU-LEU-LYS-ALA-VAL-ARG-LEU-ILE-LYS-PHE-LEU-TYR-GLN-SER-ASN PEPTITERGENT PD1 H-PRO-PRO-GLU-ASP-PRO-ALA-VAL-ASP-LEU-LEU-LYS-ASN-TYR-MET-GLN-LEU-GLY-LYS-GLN-GLN-OH

H-MET-PRO-THR-ALA-PRO-PRO-GLU-ASP-PRO-ALA-VAL-ASP-LEU-LEU-LYS-OH KALIURETIC PEPTIDE (HUMAN) SPFK H-SER-LEU-LEU-LYS-OH H-PRO-PRO-GLU-ASP-PRO-ALA-VAL-ASP-LEU-LEU-LYS-ASN-TYR-MET-GLN-OH

PREPRO-ANF (104-116), HUMAN PSTAIR peptide GLU-ASP-LEU-LEU-LYS-ALA-VAL-ARG-LEU-ILE-LYS

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acetylleucyl-leucyl-norleucinal N-AC-LEU-LEU-NORLEUCINAL N-ACETYL-LEU-LEU-NLE-CHO N-ACETYL-L-LEUCYL-L-LEUCYL-L-NORLEUCINAL N-ACETYL-LEU-LEU-NORLEUCINAL MG 101 CALPAIN INHIBITOR I;AC-LLNL-CHO;ALLN LLNL CALPAIN INHIBITOR ACETYL-LEU-LEU-NORLEUCINAL ACETYL-L-LEUCYL-L-LEUCYL-L-NORLEUCINAL AC-LEU-LEU-L-NORLEUCINAL AC-LEU-LEU-NLE-ALDEHYDE AC-LEU-LEU-NLE-CHO AC-LEU-LEU-NLE-H (ALDEHYDE) AC-LEU-LEU-NORLEUCINAL AC-LL-NORLEUCINAL ALLN ac-llnl-cho Ac-Leu-Leu-Nle-al Ac-LLnL-CHO, ALLN, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal Calpain Inhibitor I,96% N-Acetyl-L-leucine-L-leucine-L-norleucinal N-Acetyl-Leu-Leu-Norleu-al CALPAIN INHIBITOR-1;MG101;MG-101;MG 101 ALLN - CAS 110044-82-1 - Calbiochem InSolution ALLN - CAS 110044-82-1 - Calbiochem MG-101 (Calpain inhibitor I Calpain Inhibitor I, ALLN ALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal Calpain Inhibitor Ⅰ 〔N-Acetyl-L-leucyl-L-leucyl-L-norleucinal〕 InSolution? ALLN MG-101 (ALLN) N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-L-Leucinamide L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]- (S)-2-acetamido-N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-4-methyl-N-((S)-1-oxohexan-2-yl)pentanamide CALPAIN INHIBITOR I RKO,MG-101,colon cancer,Bax,HepG2,Proteasome,MG 101,Inhibitor,mitochondria,HCT116,inhibit,Apoptosis,SW480,anti-tumor N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal ALLN (DMSO solution) ALLN, cysteine proteinase inhibitor MG-101, 10 mM in DMSO MG-101 (ALLN) ，S7386 110044-82-1 C20H37N3O4 Enzyme Inhibitors by Type BioChemical Biochemicals and Reagents Calpain I A to C Substrate Analogs Enzyme Inhibitors Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates inhibitor peptides ProteasomeInhibitors