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ChemicalBook >> CAS DataBase List >>tert-butyl?4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoate

tert-butyl?4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoate

tert-butyl?4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoate Structure
tert-butyl?4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoate structure
CAS No.
2827750-24-1
Chemical Name:
tert-butyl?4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoate
Synonyms
JYS008;VH032-C1-Boc;VH032-CH2-Boc;tert-butyl?4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoate
CBNumber:
CB612231092
Molecular Formula:
C30H42N4O6S
Molecular Weight:
586.74
MDL Number:
MOL File:
2827750-24-1.mol
Last updated:2025-04-17 18:22:24
Request For Quotation

tert-butyl?4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoate Properties

Boiling point 831.5±65.0 °C(Predicted)
Density 1.219±0.06 g/cm3(Predicted)
pka 14.07±0.40(Predicted)

tert-butyl?4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoate Chemical Properties,Uses,Production

Uses

VH032-CH2-Boc is a Boc-modified VH032 (HY-120217) that serves as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins. VH032-CH2-Boc will remove the protecting group under acidic conditions and be directly used in PROTAC molecule synthesis. VH032-CH2-Boc is a key intermediate in the synthesis of PROTAC based on VHL ligand.

IC 50

VHL

tert-butyl?4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoate Preparation Products And Raw materials

Raw materials

Preparation Products

tert-butyl?4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoate Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8647 58
Zhengzhou Lingzhiyue Technology Co., Ltd 		+86-0371-55074660 +8613523716970 Lingzhiyue@aliyun.com China 3145 58
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 4690 65
Zhengzhou Convergence Chemical Co. LTD 0371-0371-53736046 13393710386 2853979814@qq.com China 10001 58
Yutong Pharmaceutical Technology (Suzhou) Co., Ltd. 0512-15851462628 15851462628 2680463261@qq.com China 5011 58
Suzhou Haiben Pharmaceutical Co., Ltd 19353112242 1816280386@qq.com China 8045 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Hubei Ruinuo Pharmaceutical Technology Co., Ltd 13165688766 3008058303@qq.com China 3000 58
Henan Mengtai Pharmaceutical Technology Co., Ltd 176345344 7 17634854698 1959525201@qq.com China 10000 58
Supplier Advantage
CR Corporation Limited 		58
Zhengzhou Lingzhiyue Technology Co., Ltd 		58
Daicel Chiral Technologies (China)CO.,LTD 65
Zhengzhou Convergence Chemical Co. LTD 58
Yutong Pharmaceutical Technology (Suzhou) Co., Ltd. 58
Suzhou Haiben Pharmaceutical Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Hubei Ruinuo Pharmaceutical Technology Co., Ltd 58
Henan Mengtai Pharmaceutical Technology Co., Ltd 58
JYS008 tert-butyl?4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoate VH032-C1-Boc VH032-CH2-Boc 2827750-24-1