CLOBENPROPIT DIHYDROBROMIDE
- CAS No.
- 145231-45-4
- Chemical Name:
- CLOBENPROPIT DIHYDROBROMIDE
- Synonyms
- CS-683;VUF 9153;Clobenpropit 2HBr;Clobenpropit dihydro;VUF 9153 DIHYDROBROMIDE;CLOBENPROPIT DIHYDROBROMIDE;Clobenpropit dihydrobromide solid;Clobenpropit dihydrobromide, 95%min;N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA;S-(3-(4(5)-Imidazolyl))propyl-N-(4-chlorobenzyl)isothiourea
- CBNumber:
- CB6122647
- Molecular Formula:
- C14H17ClN4S
- Molecular Weight:
- 308.83
- MDL Number:
- MFCD00467655
- MOL File:
- 145231-45-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| CARBAMIMIDOTHIOIC ACID,N-[(4-CHLOROPHENYL)METHYL]-, 3-(1H-IMIDAZOL-5-YL)PROPYL ESTER 95%+ | AA001KM9 | 50mg | $261 |
| 3-(1H-imidazol-5-yl)propyl (4-chlorobenzyl)carbamimidothioate 95% | X210162 | 50MG | $250 |
| 3-(1H-imidazol-5-yl)propyl (4-chlorobenzyl)carbamimidothioate 95% | X210162 | 100MG | $450 |
| Clobenpropit dihydrobromide ≥99%(HPLC) | 0752 | 10 | $193 |
| Clobenpropit dihydrobromide ≥99%(HPLC) | 0752 | 50 | $810 |
| Boiling point | 525.3±60.0 °C(Predicted) |
|---|---|
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: >20 mg/mL |
| pka | 14.55±0.10(Predicted) |
| form | solid |
| color | white |
| Water Solubility |
H2O: >20mg/mL ethanol: 3.30mg/mL DMSO: >30mg/mL |
| InChI | 1S/C14H17ClN4S.2BrH/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13;;/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19);2*1H |
| InChIKey | JIJQPEZAVLJZBO-UHFFFAOYSA-N |
| SMILES | Br[H].Br[H].Clc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1 |
| EWG's Food Scores | 1 |
| FDA UNII | RKU631JF4H |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
CLOBENPROPIT DIHYDROBROMIDE price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA001KM9 | CARBAMIMIDOTHIOIC ACID,N-[(4-CHLOROPHENYL)METHYL]-, 3-(1H-IMIDAZOL-5-YL)PROPYL ESTER 95%+ | 145231-45-4 | 50mg | $261 | 2026-05-28 | Buy |
| ACHEMBLOCK | X210162 | 3-(1H-imidazol-5-yl)propyl (4-chlorobenzyl)carbamimidothioate 95% | 145231-45-4 | 50MG | $250 | 2026-05-27 | Buy |
| ACHEMBLOCK | X210162 | 3-(1H-imidazol-5-yl)propyl (4-chlorobenzyl)carbamimidothioate 95% | 145231-45-4 | 100MG | $450 | 2026-05-27 | Buy |
| Tocris | 0752 | Clobenpropit dihydrobromide ≥99%(HPLC) | 145231-45-4 | 10 | $193 | 2021-12-16 | Buy |
| Tocris | 0752 | Clobenpropit dihydrobromide ≥99%(HPLC) | 145231-45-4 | 50 | $810 | 2021-12-16 | Buy |
CLOBENPROPIT DIHYDROBROMIDE Chemical Properties,Uses,Production
Uses
Clobenpropit Dihydrobromide and it’s analogues functions as potent histamine H3 antagonist.
Definition
ChEBI: An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA
Biological Activity
An extremely potent histamine H 3 antagonist/inverse agonist (pA 2 =9.93). Also displays partial agonist activity at H 4 receptors; induces eosinophil shape change with an EC 50 of 3 nM. Also available as part of the Histamine H 3 Receptor Tocriset™ .
Biochem/physiol Actions
Selective H3 histamine receptor antagonist that crosses the blood-brain barrier.
in vivo
Clobenpropit (15 mg/kg; i.p.; once daily for 7 days) counteracts the modulatory effects of MK-801 (HY-15084B) on dopamine and histamine levels and prevents MK-801-induced hyper locomotor behaviors[1].
Clobenpropit (1, 2, 5 μmoL/kg; i.v.) causes a resuscitating effect in rats subjected to the hemorrhagic shock[2].
| Animal Model: | 150-200g, 12-week-old male wistar albino rats[1] |
| Dosage: | 15 mg/kg |
| Administration: | I.p.; once daily for 7 days |
| Result: | Exhibited a significant reduction of hyperlocomotor activities induced by a single-dose administration of MK-801 (0.2 mg/kg, i.p.), and reduced the MK-801-induced dopamine release, exhibited further increase in histamine levels in the hypothalamus. |
| Animal Model: | 205-470g, adult male Wistar rats[2] |
| Dosage: | 1, 2, 5 μmoL/kg (after 6-hydroxydopamine (50 mg/kg (SC) for 3 consecutive days) |
| Administration: | I.v. |
| Result: | Triggered a statistically significant increase of mean arterial pressure (MAP) (dose 2 μmol/kg) and heart rate (HR) (doses of 1, 2, 5 μmol/kg). |
IC 50
H3 receptor
CLOBENPROPIT DIHYDROBROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
CLOBENPROPIT DIHYDROBROMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9897 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15815 | 69 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
View Lastest Price from CLOBENPROPIT DIHYDROBROMIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | Clobenpropit 2HBr
145231-45-4
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
-
- Clobenpropit 2HBr
145231-45-4
- $1520.00-2500.00
- TargetMol Chemicals Inc.
