(2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]chroman-6-ol
![(2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]chroman-6-ol Structure](CAS/GIF/1721-51-3.gif)
- CAS No.
- 1721-51-3
- Chemical Name:
- (2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]chroman-6-ol
- Synonyms
- C14153;ξ1-Tokoferol;ξ1-Tocopherol;tocotrienol, alpha;
D -α-Tocotrienol;5,7,8-Trimethyltocotrienol;D-α-Tocotrienol, CAS 1721-51-3;D-alpha-Tocotrienol (Rice) (>(2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]chroman-6-ol;3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol
- CBNumber:
- CB61235690
- Molecular Formula:
- C29H44O2
- Molecular Weight:
- 424.66
- MDL Number:
- MOL File:
- 1721-51-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 30-31°C |
|---|---|
| Boiling point | 541.7±50.0 °C(Predicted) |
| Density | 0.960±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| pka | 11.40±0.40(Predicted) |
| form | liquid |
| color | colorless to brown |
| biological source | rice |
| InChIKey | RZFHLOLGZPDCHJ-XZXLULOTSA-N |
| SMILES | O1[C@@](CCc2c1c(c(c(c2C)O)C)C)(CC\C=C(\CC\C=C(\CCC=C(C)C)/C)/C)C |
| FDA UNII | 42UVL44LY7 |
| EPA Substance Registry System | 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)- (1721-51-3) |
| UNSPSC Code | 12352205 |
| NACRES | NA.79 |
SAFETY
Risk and Safety Statements
| WGK Germany | 3 |
|---|---|
| TSCA | TSCA listed |
| Storage Class | 11 - Combustible Solids |
(2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]chroman-6-ol price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T0452 | D-α-Tocotrienol ≥75% (GC) | 1721-51-3 | 10mg | $406 | 2025-07-31 | Buy |
| Biosynth | FT138489 | D-alpha-Tocotrienol | 1721-51-3 | 5mg | $900 | 2026-06-04 | Buy |
| Biosynth | FT138489 | D-alpha-Tocotrienol | 1721-51-3 | 2mg | $900 | 2026-06-04 | Buy |
| Biosynth | FT138489 | D-alpha-Tocotrienol | 1721-51-3 | 1mg | $900 | 2026-06-04 | Buy |
| Biosynth | FT138489 | D-alpha-Tocotrienol | 1721-51-3 | 10mg | $908.6 | 2026-06-04 | Buy |
(2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]chroman-6-ol Chemical Properties, Uses, Production
Uses
Alpha-Tocotrienol is a vitamin E analog with anti-apoptotic neuroprotective action and antioxidant properties. Alpha-Tocotrienol prevents oxidative stress-independent apoptotic cell death, DNA cleavage, and nuclear morphological changes[1].
Definition
ChEBI: A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a farnesyl chain at position 2. It has been found in palm oil derived from Elaeis guineensis.
Biological Activity
α-Tocotrienol is an effective free radical scavengerand elicits protective functionality during oxidative stress in microsomes. It is a strong antioxidant, which reduces inflammation and is used in cancer treatment. α-tocotrienol supplementation may reduce cholesterol levels in hypercholesterolemia. α-tocotrienol is neuroprotective as it blocks glutamate-induced cell death in neuronal cells.', 'α-Tocotrienol may be used along with other isoforms to differentiate tocotrienol activities.', 'Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. α-tocotrienol demonstrates neuroprotective properties by blocking glutamate-induced cell death in neuronal cells.
References
[1] Fumitaka Osakada, et al. Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology. 2004 Nov;47(6):904-15. DOI:10.1016/j.neuropharm.2004.06.029
(2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]chroman-6-ol Preparation Products And Raw materials
Raw materials
Preparation Products
(2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]chroman-6-ol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13323 | 58 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4508 | 55 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9170 | 60 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai ChengShao Biological Technology Co., Ltd. | 021-61847300 13341622919 | shcss01@163.com | China | 4806 | 58 |
| Zhejiang Lianshuo Biotechnology Co., Ltd. | 18616526224 | lianshuo@vip.126.com | China | 9605 | 58 |
| Shanghai Fusheng Industrial Co., LTD | 021-52961053 13524666654 | 3004902811@qq.com | China | 9724 | 58 |
