Albuterol sulfate
- CAS No.
- 51022-70-9
- Chemical Name:
- Albuterol sulfate
- Synonyms
- SALBUTAMOL SULFATE;SALBUTAMOL SULPHATE;ALBUTEROL SULPHATE;SULBUTAMOL SULFATE;Albuterol hemisulfate;SALBUTAMOL HEMISULFATE;(R,S)-Salbutamol Sulphate;1-(4-hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino)ethanolsulfate;Mozal;Volma
- CBNumber:
- CB6129525
- Molecular Formula:
- C13H23NO7S
- Molecular Weight:
- 337.39
- MDL Number:
- MFCD00055200
- MOL File:
- 51022-70-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 180 °C |
|---|---|
| Flash point | 250 °C |
| storage temp. | 2-8°C |
| solubility | 1 M NaOH: soluble50 mg/ml, clear to slightly hazy, yellow-green |
| form | Solid |
| color | White |
| Water Solubility | Soluble in water and 1M sodium hydroxide (50 mg/ml). |
| Merck | 216 |
| BCS Class | 1 |
| Major Application |
clinical forensics and toxicology pharmaceutical (small molecule) |
| InChI | InChI=1S/C13H21NO3.H2O4S/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4) |
| InChIKey | OVICLFZZVQVVFT-UHFFFAOYSA-N |
| SMILES | CC(C)(NCC(O)C1C=CC(O)=C(CO)C=1)C.S(O)(O)(=O)=O |
| CAS DataBase Reference | 51022-70-9(CAS DataBase Reference) |
| FDA UNII | 021SEF3731 |
| NCI Drug Dictionary | albuterol sulfate |
| UNSPSC Code | 41116107 |
| NACRES | NA.76 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317-H351-H361fd | |||||||||
| Precautionary statements | P202-P261-P272-P280-P302+P352-P308+P313 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 43-22 | |||||||||
| Safety Statements | 36/37-36 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ZE4400000 | |||||||||
| HS Code | 29225090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Carc. 2 Repr. 2 Skin Sens. 1 |
|||||||||
| NFPA 704 |
|
Albuterol sulfate price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S0150000 | Salbutamol sulfate European Pharmacopoeia (EP) Reference Standard | 51022-70-9 | 50 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR1053 | Albuterol sulfate Pharmaceutical Secondary Standard; Certified Reference Material | 51022-70-9 | 1g | $114 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP302 | Salbutamol sulfate British Pharmacopoeia (BP) Reference Standard | 51022-70-9 | 100MG | $280 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1012633 | Albuterol sulfate United States Pharmacopeia (USP) Reference Standard | 51022-70-9 | 200mg | $455 | 2026-04-30 | Buy |
| TCI Chemical | S0531 | Salbutamol Hemisulfate | 51022-70-9 | 1G | $33 | 2026-04-30 | Buy |
Albuterol sulfate Chemical Properties, Uses, Production
Preparation
1. Starting from p-hydroxyacetophenone, a synthesis is achieved through 8 steps: bromination, hydrolysis, amination, hydrolysis, neutralization, catalytic hydrogenation, hydrogenolysis, and salt formation. The overall yield is 11%–13%. However, this method requires harsh reaction conditions, causes severe waste pollution, and has high costs. 2. Using salicylaldehyde and acyl chloride as raw materials, 4-bromoacetyl salicylaldehyde and 4-chloroacetyl salicylaldehyde are obtained by Friedel-Crafts acylation. These are then converted to 5-11-dimethylethyl)amino[acetyl-2-hydroxybenzaldehyde hydrochloride via a co-reduction reaction with potassium borohydride and zinc chloride at room temperature, followed by salt formation with sulfuric acid to obtain salbutamol sulfate.
3. Using salicylaldehyde and tert-butylamine as starting materials, a three-step one-pot reaction of condensation, esterification, and Fries rearrangement is carried out to prepare 2-chloro-1-{〔(1,1-dimethylethyl)iminomethyl-4-hydroxyphenyl}-ethyl ketone. Then, a three-step one-pot reaction of condensation, hydrolysis, and salt formation is carried out to convert it into 5-{〔(1,1-dimethylethyl)aminoacetyl}-2-caryophyllene benzaldehyde hydrochloride. Finally, the product is obtained by neutralization with sodium methoxide, catalytic transfer hydrogenation reduction, and salt formation.
Description
Albuterol sulfate (Brand name: PROVENTIL® HFA) is the sulfate form of albuterol which is also known as salbutamol. It is a kind of short-acting, selective beta2-adrenergic receptor agonist being capable of opening up the medium and large airways in the lungs. It is mainly used for the treatment of bronchospasm (induced by bronchial asthma or exercise) as well as chronic obstructive pulmonary disease (COPD). Albuterol sulfate takes effects through directly biding to the beta (2)-adrenergic receptors in the lung and causing relaxation of bronchial smooth muscles. This relaxation is mediated by its effect of stimulating cAMP production through activating adenylate cyclase, further inhibiting the phosphorylation of myosin and lowering the intracellular calcium level. Albuterol sulfate can also be used to treat acute hyperkalemia of the blood.
Chemical Properties
Albuterol sulfate is a white or practically white powder, freely soluble in water and slightly soluble in ethanol.
Uses
Albuterol Sulfate belongs to a class of bronchodilator drugs called β2-adrenoceptor agonists. It is a prescription medicine used to treat symptoms of bronchospasm. Albuterol Sulfate may be used alone or with other medications.
Definition
ChEBI: Albuterol sulfate is an ethanolamine sulfate salt. It is functionally related to an albuterol.
brand name
Accuneb (Dey); Proair (IVAX); Proventil (Schering); Ventolin (GlaxoSmithKline); Volmax (Muro); Vospire (Odyssey).
General Description
Albuterol belongs to the class of medicines known as bronchodilators. It is also called a short-acting beta-agonist (SABA).
Biological Activity
Non-selective β -adrenergic agonist, more potent at β 2 than β 1 receptors.
Veterinary Drugs and Treatments
Albuterol is used principally in dogs and cats for its effects on bronchial smooth muscle to alleviate bronchospasm or cough. It is also used in horses as a bronchodilator.
storage
Store at RT
Mode of action
Albuterol Sulfate is the sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction.
References
https://en.wikipedia.org/wiki/Salbutamol
https://www.drugbank.ca/drugs/DB01001
http://www.rxlist.com/albuterol-sulfate-drug/indications-dosage.htm
Albuterol sulfate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Augda Biotechnology Co., Ltd | 15071299552 | 262933239@qq.com | China | 7201 | 58 |
| Hubei Chenxin Pharmaceutical Co., Ltd. | 18696113233 | like1076463918@163.com | China | 3117 | 58 |
| xi'an renyang Biotechnology Co., Ltd. | 13299086402 | renyangbiotech@163.com | China | 93 | 58 |
| Guangzhou Jicheng Import and Export Trading Co.，Ltd | 13682223272 | 173901442@qq.com | China | 477 | 58 |
| Shanghai Baoda Biotechnology Co., Ltd. | 15900974796 | gjzhu@blpharm.net | China | 197 | 58 |
| Hubei Yuanmeng Biological Technology Co., Ltd. | 027-68897569 18120462897 | 2225602544@qq.com | China | 4337 | 58 |
| Shandong Risen-Sun Pharmaceutical Co., Ltd. | +86-0538-8923092 13958575904 | risensun-sales@jewim.com.cn | China | 43 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
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View Latest Price from Albuterol sulfate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | Albuterol sulfate
51022-70-9
|
$10.00 | 1ASSAYS | 99% | 10 ton | RongNa Biotechnology Co.,Ltd | |
 |
2026-09-14 | (R,S)-Salbutamol Sulphate
51022-70-9
|
1kg | 99% up by HPLC | 20TONS | Sinoway Industrial co., ltd. | ||
![1-benzyl-4-hydroxy-2-methyl-1H-benzo[d]imidazole-6-carboxylic acid pictures](/ProductImageEN/2024-03/Small/5569a4da-3a5e-4d8b-84be-8c30ff364ad1.png) |
2026-08-25 | 1-benzyl-4-hydroxy-2-methyl-1H-benzo[d]imidazole-6-carboxylic acid
1640981-19-6
|
$95.00-950.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd |
-
- Albuterol sulfate
51022-70-9
- $10.00
- 99%
- RongNa Biotechnology Co.,Ltd
-
- (R,S)-Salbutamol Sulphate
51022-70-9
- 99% up by HPLC
- Sinoway Industrial co., ltd.
-
- 1-benzyl-4-hydroxy-2-methyl-1H-benzo[d]imidazole-6-carboxylic acid
1640981-19-6
- $95.00-950.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
