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Triphenylmethanol

CAS No.
76-84-6
Chemical Name:
Triphenylmethanol
Synonyms
TRT-OH;TRIPHENYLCARBINOL;TRITYL ALCOHOL;Triphenylmethanol, (Triphenyl carbinol;Methanol, triphenyl-;Tritanol;Triphenylmethanol,98%;Ih-Tetrazole;tirphenylmethanol;Triphenylmethanol ,99%
CBNumber:
CB3335936
Molecular Formula:
C19H16O
Molecular Weight:
260.33
MDL Number:
MFCD00004445
MOL File:
76-84-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:53:10
Product description Number Pack Size Price
Zidovudine impurity D European Pharmacopoeia (EP) Reference Standard Y0001654 15 mg $127
Triphenylmethanol for synthesis 8.21196 50g $82.8
Losartan Impurity G certified reference material, pharmaceutical secondary standard PHR3668 30 mg $566
Triphenylmethanol for synthesis 8.21196 250g $219
Triphenylmethanol 97% 134848 50g $75.7
More product size

Triphenylmethanol Properties

Melting point 160-163 °C (lit.)
Boiling point 360 °C (lit.)
Density d40 1.199
refractive index 1.6220 (estimate)
Flash point 360-380°C
storage temp. 2-8°C
solubility dioxane: 0.1 g/mL, clear
pka 12.73±0.29(Predicted)
form Fine Crystalline Powder
color White to light yellow
Appearance White to Light yellow to Light orange powder to crystal
Water Solubility INSOLUBLE
Merck 14,9739
BRN 1460837
Stability Stable. Combustible. Incompatible with oxidizing agents, acids, acid chlorides, acid anhydrides.
InChI 1S/C19H16O/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15,20H
InChIKey LZTRCELOJRDYMQ-UHFFFAOYSA-N
SMILES OC(c1ccccc1)(c2ccccc2)c3ccccc3
CAS DataBase Reference 76-84-6(CAS DataBase Reference)
FDA UNII U97Q0OU9KB
NIST Chemistry Reference Benzenemethanol, «alpha»,«alpha»-diphenyl-(76-84-6)
EPA Substance Registry System Benzenemethanol, .alpha.,.alpha.-diphenyl- (76-84-6)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  38-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
TSCA  TSCA listed
HS Code  29062900
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
1
0 0

Triphenylmethanol price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001654 Zidovudine impurity D European Pharmacopoeia (EP) Reference Standard 76-84-6 15 mg $127 2026-04-30 Buy
Sigma-Aldrich 8.21196 Triphenylmethanol for synthesis 76-84-6 50g $82.8 2026-04-30 Buy
Sigma-Aldrich PHR3668 Losartan Impurity G certified reference material, pharmaceutical secondary standard 76-84-6 30 mg $566 2026-04-30 Buy
Sigma-Aldrich 8.21196 Triphenylmethanol for synthesis 76-84-6 250g $219 2026-04-30 Buy
Sigma-Aldrich 134848 Triphenylmethanol 97% 76-84-6 50g $75.7 2026-04-30 Buy
Product number Packaging Price Buy
Y0001654 15 mg $127 Buy
8.21196 50g $82.8 Buy
PHR3668 30 mg $566 Buy
8.21196 250g $219 Buy
134848 50g $75.7 Buy

Triphenylmethanol Chemical Properties,Uses,Production

Chemical Properties

Triphenylmethanol is a white powder or colorless, isolated crystals that are soluble in alcohol, ether, and benzene. It turns dark yellow when dissolved in concentrated sulfuric acid, colorless when dissolved in glacial acetic acid, and is insoluble in water and petroleum ether. It distills at 360-380°C without decomposition.

Uses

Triphenylmethanol (Zidovudine EP Impurity D) is a triaryl methane derivative as antiproliferative agent.

Uses

Triphenylmethanol is used as a reagent in the research laboratory. It acts as an intermediate in the production of the commercially useful triarylmethane dyes. It is used in the preparation of triphenylmethane. It is also used as an antiproliferative agent. Further, it is used in the preparation of two-electron reduction product of pyrylogen. In addition to this, it reacts with triphenylphosphine oxide to form a 1:1 molecular complex. It serves as a specific clathrate host for methanol and dimethyl sulphoxide and forms clathrate inclusion complexes.
Triphenylmethanol was used in the synthesis of of the two-electron reduction product of pyrylogen.
It undergoes reduction to triphenylmethane by 9, 10-dihydro-10-methylacridine in the presence of perchloric acid.

Preparation

Triphenylmethanol synthesis: Triphenylmethanol was prepared by the action of benzene with carbon tetrachloride in the presence of Aluminum chloride, followed by acidification and hydrolysis.
Triphenylmethanol can also be prepared by the reaction of phenylmagnesium bromide with methyl benzoate (instead of benzophenone).
Synthesis of Triphenylmethanol

Reactions

The first one is the formation of the triphenylmethyl bromide from the reaction of triphenylmethanol with hydrobromic acid.
The second reaction is the formation of an ether from the reaction of triphenylmethanol with methanol in acidic conditions.
reaction of triphenylmethanol

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 839, 1955
The Journal of Organic Chemistry, 57, p. 4555, 1992 DOI: 10.1021/jo00042a044

General Description

Triphenylmethanol forms 1:1 molecular complex with triphenylphosphine oxide. It is a specific clathrate host for methanol and dimethyl sulphoxide and forms clathrate inclusion complexes. It undergoes reduction to triphenylmethane by 9, l0-dihydro-10-methylacridine in the presence of perchloric acid.

Materials Uses

Triphenylmethanol (TPOH) is a non-fluorescent compound that emits strong fluorescence in an aggregate state or on a solid surface after irradiation by UV light at 254 nm (UV1). Interestingly, the photo-induced fluorescence of TPOH was quenched when irradiated by UV light at a longer wavelength of 365 nm (UV2) and further repeatable on and off by UV1 and UV2, respectively. The reversible activation and deactivation of fluorescence at a solid surface could be repeatable at least 5 times. TPOH is thus applied for rewritable photopatterning tuned by UV light[1].

Purification Methods

Crystallise the carbinol from EtOH, MeOH, CCl4 (4mL/g), *benzene, hexane or pet ether (b 60-70o). Dry it at 90o. [Ohwada et al. J Am Chem Soc 108 3029 1986, Beilstein 6 IV 5014.]

References

[1] Zheng, Yue et al. “Photoactivatable aggregation-induced emission of triphenylmethanol.” Chemical Communications 81 (2017): 11130–11133.

50653-07-1
76-84-6
Synthesis of Triphenylmethanol from Benzene, 1,1',1''-[[(trimethylsilyl)oxy]methylidyne]tris-
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Triphenylmethanol pictures 2026-08-31 Triphenylmethanol
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$10.00-50.00 1kg 99%,Electronic grade(Single metal impurity≤ 100ppb) or pharmaceutical grade 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
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$2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
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