3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
![3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] Structure](CAS/GIF/38309-60-3.gif)
- CAS No.
- 38309-60-3
- Chemical Name:
- 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
- Synonyms
- 3H-Spiro[2-benzofuran-1,4'-piperidine;3H-spiro[isobenzofuran-1,4'-piperidine;3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE];3H-spiro[isobenzofuran-1,4'-piperidine];Spiro[isobenzofuran-1(3H),4'-piperidine];spiro[isobenzofuran-1(3H),4'-piperidine] hydrobroMide;3H-Spiro[2-benzofuran-1,4′-piperidine], CAS 38309-60-3
- CBNumber:
- CB6132635
- Molecular Formula:
- C12H15NO
- Molecular Weight:
- 189.25
- MDL Number:
- MFCD06738867
- MOL File:
- 38309-60-3.mol
SAFETY
Risk and Safety Statements
| Risk Statements | 36/37/38 |
|---|---|
| Safety Statements | 26-36/37/39 |
3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | S699885 | 3H-Spiro[2-benzofuran-1,4''-piperidine] | 38309-60-3 | 50mg | $65 | 2021-12-16 | Buy |
| Matrix Scientific | 072834 | 3H-Spiro[2-benzofuran-1,4'-piperidine] 95+% | 38309-60-3 | 500mg | $200 | 2021-12-16 | Buy |
| AK Scientific | W5907 | 3H-Spiro[2-benzofuran-1,4'-piperidine] | 38309-60-3 | 1g | $272 | 2021-12-16 | Buy |
| Matrix Scientific | 072834 | 3H-Spiro[2-benzofuran-1,4'-piperidine] 95+% | 38309-60-3 | 1g | $360 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0094119 | 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] 95.00% | 38309-60-3 | 1G | $1070.84 | 2021-12-16 | Buy |
3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] Chemical Properties,Uses,Production
Synthesis
![Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-(phenylmethyl)-](/CAS/20180629/GIF/37663-43-7.gif)
37663-43-7
![3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]](/CAS/GIF/38309-60-3.gif)
38309-60-3
Step 3: 1'-(phenylmethyl)spiro[isophenylurea-1(3H),4'-piperidine] (119 g, 425.9 mmol) was dissolved in ethanol (1 L) and nickel ruanne (12 g) was added and stirred for 1 h at room temperature under argon protection to remove impurities that may poison the catalyst. Subsequently, nickel ruanne was removed by filtration and the filtrate was transferred to a steel autoclave, 10% Pd/C (Degussa Nr. 1835) (12 g) was added, and hydrogenated at 5 bar hydrogen pressure and 40 °C for 19 h. HPLC analysis showed that 2.7% of the starting material remained unreacted. Therefore, the catalyst was removed by filtration and fresh 10% Pd/C (4 g) was added to the filtrate and hydrogenation was continued under the same conditions for 24 h. The catalyst was removed by filtration and the catalyst was added to the filtrate. Upon completion of the reaction, the catalyst was removed by filtration and the ethanol was removed by evaporation to give a light yellow oily substance. The oily substance was co-stirred with heptane (1 L) and spontaneously crystallized to give the white solid product 3H-spiro[2-benzofuran-1,4'-piperidine] (65 g, 80% yield). Mass spectrometry: m/z = 190 [M + H]+.
References
[1] Patent: US2008/171759, 2008, A1. Location in patent: Page/Page column 20
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 14, p. 5080 - 5095
3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 4000 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49977 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
View Lastest Price from 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] pictures](/ProductImageEN1/2024-08/Small/f55464e0-3d66-4bba-98ec-b323fc9376bf.png) |
2024-08-17 | 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
38309-60-3
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
![3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/094404a6-9a60-4d33-bc1b-b3550f14dbc7.png) |
2020-01-13 | 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
38309-60-3
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
38309-60-3
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
38309-60-3
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
