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3H-Spiro[2-benzofuran-1,4'-piperidine]

3H-Spiro[2-benzofuran-1,4'-piperidine] structure

CAS No.: 38309-60-3

Chemical Name:: 3H-Spiro[2-benzofuran-1,4'-piperidine]

Synonyms: 3H-Spiro[2-benzofuran-1,4'-piperidine;3H-Spiro[2-benzofuran-1,4'-piperidine];3H-spiro[isobenzofuran-1,4'-piperidine;3H-spiro[isobenzofuran-1,4'-piperidine];Spiro[isobenzofuran-1(3H),4'-piperidine];spiro[isobenzofuran-1(3H),4'-piperidine] hydrobroMide;3H-Spiro[2-benzofuran-1,4′-piperidine], CAS 38309-60-3

CBNumber:: CB6132635

Molecular Formula:: C12H15NO

Molecular Weight:: 189.25

MDL Number:: MFCD06738867

MOL File:: 38309-60-3.mol

TDS File:: TDS

Last updated:2026-09-12 18:53:49

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3H-Spiro[2-benzofuran-1,4'-piperidine] Properties

Melting point	84-86 °C
Boiling point	321.3±42.0 °C(Predicted)
Density	1.14±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	10.17±0.20(Predicted)

SAFETY

Risk and Safety Statements

Risk Statements	36/37/38
Safety Statements	26-36/37/39

3H-Spiro[2-benzofuran-1,4'-piperidine] price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	289524	3H-Spiro[2-benzofuran-1,4'-piperidine] Asreported	38309-60-3	250mg	$372	2026-06-03	Buy
Usbiological	289524	3H-Spiro[2-benzofuran-1,4'-piperidine] Asreported	38309-60-3	500mg	$516	2026-06-03	Buy
Usbiological	289524	3H-Spiro[2-benzofuran-1,4'-piperidine] Asreported	38309-60-3	1g	$889	2026-06-03	Buy
Usbiological	289524	3H-Spiro[2-benzofuran-1,4'-piperidine] Asreported	38309-60-3	2g	$1261	2026-06-03	Buy
Usbiological	289524	3H-Spiro[2-benzofuran-1,4'-piperidine] Asreported	38309-60-3	5g	$1812	2026-06-03	Buy

Product number	Packaging	Price	Buy
289524	250mg	$372	Buy
289524	500mg	$516	Buy
289524	1g	$889	Buy
289524	2g	$1261	Buy
289524	5g	$1812	Buy

3H-Spiro[2-benzofuran-1,4'-piperidine] Chemical Properties,Uses,Production

Synthesis

Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-(phenylmethyl)-

37663-43-7

38309-60-3

Step 3: 1'-(phenylmethyl)spiro[isophenylurea-1(3H),4'-piperidine] (119 g, 425.9 mmol) was dissolved in ethanol (1 L) and nickel ruanne (12 g) was added and stirred for 1 h at room temperature under argon protection to remove impurities that may poison the catalyst. Subsequently, nickel ruanne was removed by filtration and the filtrate was transferred to a steel autoclave, 10% Pd/C (Degussa Nr. 1835) (12 g) was added, and hydrogenated at 5 bar hydrogen pressure and 40 °C for 19 h. HPLC analysis showed that 2.7% of the starting material remained unreacted. Therefore, the catalyst was removed by filtration and fresh 10% Pd/C (4 g) was added to the filtrate and hydrogenation was continued under the same conditions for 24 h. The catalyst was removed by filtration and the catalyst was added to the filtrate. Upon completion of the reaction, the catalyst was removed by filtration and the ethanol was removed by evaporation to give a light yellow oily substance. The oily substance was co-stirred with heptane (1 L) and spontaneously crystallized to give the white solid product 3H-spiro[2-benzofuran-1,4'-piperidine] (65 g, 80% yield). Mass spectrometry: m/z = 190 [M + H]+.

References

[1] Patent: US2008/171759, 2008, A1. Location in patent: Page/Page column 20
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 14, p. 5080 - 5095

3H-Spiro[2-benzofuran-1,4'-piperidine] Preparation Products And Raw materials

Raw materials

Spiro[isobenzofuran-1(3H),4'-piperidine], 1'-(phenylmethyl)- Hydrogen Ethanol

Preparation Products

3H-Spiro[2-benzofuran-1,4'-piperidine] Suppliers

Global( 81)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ChemFuture PharmaTech (Jiangsu) Ltd	5108538618	suger.wang@chemfuture.com	China	832	65
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.	21-57721279 18121011378	sales@shydchem.com.cn	China	998	56
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66
China Langchem Inc.	0086-21-58956006		China	7798	57
skychemical Co.Ltd	021-20958197 20965099	sales@skychemical.com	China	1182	57
Hangzhou Sage Chemical Co., Ltd.	+86057186818502 13588463833	info@sagechem.com	China	10265	58

Supplier	Advantage
ChemFuture PharmaTech (Jiangsu) Ltd	65
Capot Chemical Co., Ltd	66
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.	56
Shangchem Co., Ltd.	52
Pure Chemistry Scientific Inc.	62
Shanghai Hanhong Scientific Co.,Ltd.	64
China DongFan Chemical Co.,LTD	66
China Langchem Inc.	57
skychemical Co.Ltd	57
Hangzhou Sage Chemical Co., Ltd.	58

View Lastest Price from 3H-Spiro[2-benzofuran-1,4'-piperidine] manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-08-17	3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] 38309-60-3	$1.00	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd
	2020-01-13	3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE] 38309-60-3	$9.80	1g	≥99%	100kg	Career Henan Chemical Co

3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
38309-60-3
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDINE]
38309-60-3
$9.80
≥99%
Career Henan Chemical Co

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