ungeremine
- CAS No.
- 2121-12-2
- Chemical Name:
- ungeremine
- Synonyms
- C12189;ungeremine;Ungerimine;Lycobetaine（Ungeremine）;[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridinium, 4,5-dihydro-2-hydroxy-
- CBNumber:
- CB61329876
- Molecular Formula:
- C16H12NO3
- Molecular Weight:
- 266.275
- MDL Number:
- MFCD01716209
- MOL File:
- 2121-12-2.mol
- MSDS File:
- SDS
| Melting point | 270-272℃ (dec.) |
|---|---|
| Boiling point | 409.48°C (rough estimate) |
| Density | 1.1727 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | -20°C |
| solubility | Methanol: 10 mg/ml |
| form | A solid |
| FDA UNII | 9EVC5B2RPS |
ungeremine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 34549 | Ungeremine ≥98% | 2121-12-2 | 1mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 34549 | Ungeremine ≥98% | 2121-12-2 | 5mg | $238 | 2026-04-30 | Buy |
| Cayman Chemical | 34549 | Ungeremine ≥98% | 2121-12-2 | 10mg | $418 | 2026-04-30 | Buy |
| Cayman Chemical | 34549 | Ungeremine ≥98% | 2121-12-2 | 25mg | $913 | 2026-04-30 | Buy |
| Biorbyt Ltd | orb573053 | Lycobetaine (Ungeremine) >98%,StandardReferencesGrade | 2121-12-2 | 100mg | $640 | 2026-05-06 | Buy |
ungeremine Chemical Properties,Uses,Production
Description
Ungeremine is a betaine-type alkaloid that has been found in C. zeylanicum and has diverse biological activities.1,2,3,4 It is an inhibitor of acetylcholinesterase (AChE; IC50 = 0.35 µM).2 Ungeremine acts as a topoisomerase poison, inducing double-strand breaks in DNA by stabilizing the linkage between topoisomerase IIβ and DNA.3 It inhibits the relaxation of supercoiled DNA by human topoisomerase I and -IIα and E. coli topoisomerase I and -IV (IC50s = 6.1, 25.8, 15, and 7.3 µM, respectively).4 Ungeremine inhibits the growth of HL-60, MOLT-4, K562, U937, and LXFL 529L cells (IC50s = 1.3, 0.7, 0.8, 2.5, and 1.2 µM, respectively). It is cytotoxic to a variety of drug-sensitive and -resistant cancer cells (IC50s = 4.89-6.45 and 3.67-75.24 µM, respectively) and induces ferroptosis, necroptosis, apoptosis, and autophagy in CCRF-CEM leukemia cells. Ungeremine (60 mg/kg twice per week) also reduces tumor growth in a GXF251L mouse xenograft model.3WARNING This product is not for human or veterinary use.
Definition
ChEBI: A natural product found particularly in Pancratium maritimum and Nerine bowdenii.
ungeremine Preparation Products And Raw materials
Raw materials
Preparation Products
ungeremine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 8379 | 60 |
| Shanghai Standard Technology Co.,Ltd. | 021-021-57127007-6622-6622 17621252073 | luzh@nature-standard.com | China | 3021 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Qingdao haohai anjie pharmaceutical technology co., ltd. | 156-6622-8711 18639325623 | chen.wanglin@hmgj.group | China | 1900 | 58 |
| Naturewill Biotechnology Co., Ltd. | 028-82632533 18113192475 | 3157321941@qq.com | China | 4993 | 58 |
| Chengdu Biopurify Ltd. | 82633860 18982077548 | cwb1@biopurify.cn | China | 4630 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +86-18080483897 | sales@biopurify.com | China | 4616 | 58 |
