3-Methoxycarbonylphenylboronic acid
- CAS No.
- 99769-19-4
- Chemical Name:
- 3-Methoxycarbonylphenylboronic acid
- Synonyms
- AKOS BRN-0125;3-Methoxycarbonylphe;2-Methoxybutan-1-amine;METHYL 3-BORONOBENZOATE;3-Carbomethoxybenzeneboronic acid;3-Methoxycarbonylphenylboronic aci;(3-carbomethoxyphenyl)boronic acid;3-METHOXYCARBONYLPHENYLBORONIC ACID;3-METHOXYCARBONYLPHENYLBARONIC ACID;3-Boronobenzoic Acid 1-Methyl Ester
- CBNumber:
- CB6133384
- Molecular Formula:
- C8H9BO4
- Molecular Weight:
- 179.97
- MDL Number:
- MFCD02093046
- MOL File:
- 99769-19-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 205-208 °C(lit.) |
|---|---|
| Boiling point | 359.9±44.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 7.74±0.10(Predicted) |
| form | Powder |
| color | White to off-white |
| Water Solubility | Reacts with water. |
| InChI | InChI=1S/C8H9BO4/c1-13-8(10)6-3-2-4-7(5-6)9(11)12/h2-5,11-12H,1H3 |
| InChIKey | ALTLCJHSJMGSLT-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=CC(B(O)O)=C1 |
| CAS DataBase Reference | 99769-19-4(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
3-Methoxycarbonylphenylboronic acid price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 591130 | 3-Methoxycarbonylphenylboronic acid | 99769-19-4 | 1g | $21.37 | 2026-04-30 | Buy |
| Sigma-Aldrich | 591130 | 3-Methoxycarbonylphenylboronic acid | 99769-19-4 | 5g | $65.7 | 2026-04-30 | Buy |
| TCI Chemical | M1906 | 3-(Methoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride) | 99769-19-4 | 1g | $17 | 2026-04-30 | Buy |
| TCI Chemical | M1906 | 3-(Methoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride) | 99769-19-4 | 5g | $42 | 2026-04-30 | Buy |
| Usbiological | 281751 | 3-Methoxycarbonylphenylboronic acid Asreported | 99769-19-4 | 5g | $322 | 2026-06-03 | Buy |
3-Methoxycarbonylphenylboronic acid Chemical Properties, Uses, Production
Chemical Properties
White to light yellow crystal powde
Uses
3-Methoxycarbonylphenylboronic acid can be used in the preparation of substituted pyrazolylpyrimidinamine derivative for use as protein kinase inhibitors and suzuki reaction.
Uses
Reagent used for tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation sequence, copper-mediated ligandless aerobic fluoroalkylation of arylboronic acids with fluoroalkyl iodides, one-pot ipso-nitration of arylboronic acids, copper-catalyzed nitration, cyclocondensation followed by palladium-phosphine-catalyzed Suzuki-Miyaura coupling. Reagent used in Preparation of biaryls via nickel-catalyzed Suzuki-Miyaura cross-coupling reaction of aryl halides with arylboronic acid6, chromenones and their bradykinin B1 antagonistic active, Pt nanoparticles at Photoactive metal-organic frameworks resulting in efficient hydrogen evolution via synergistic photoexcitation and electron injecti, salicylate-based thienylbenzoic acids as E. coli methionine aminopeptidase inhibitor.
Synthesis
67-56-1
25487-66-5
99769-19-4
In a 20 L reactor, 8.0 Kg of anhydrous methanol and 1.66 Kg (10 mol) of 3-carboxyphenylboronic acid were added and stirring was initiated. The reaction mixture was heated to 55°C and the temperature was maintained in the range of 55-65°C. 1.78Kg (15mol) of thionyl chloride was slowly added dropwise to the reaction kettle. After completion of the reaction, reflux was continued for 2-3 hours. The completion of the reaction was confirmed by TLC (unfolding agent: n-heptane/ethyl acetate = 2:1). The reaction solution was then cooled and subjected to reduced pressure distillation to remove the solvent. N-heptane was added and the mixture was cooled to -10 to 0°C and filtered with continuous stirring for 1 hour. The solid product was collected and dried at 80 °C until the absence of impurities was confirmed by HNMR (DMSO-d6, δ=3.16 ppm). The dried solid was stirred at room temperature and water was added, filtered and dried at room temperature to give 1.75 Kg of the final white solid product m-Carbomethoxyphenylboronic acid in 97.1% yield.
References
[1] Patent: CN106188117, 2016, A. Location in patent: Paragraph 0015
3-Methoxycarbonylphenylboronic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Henan Aosman Biotechnology Co., LTD | 13761588971 17719817155 | 2366079749@qq.com | China | 3009 | 58 |
| Zhuhai Aobokai Biomedical Technology Co., Ltd. | 400-0628126 | sales-team@aobchem.com.cn | China | 49995 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
View Latest Price from 3-Methoxycarbonylphenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-Methoxycarbonylphenylboronic acid
99769-19-4
|
$1.20-34.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2021-07-13 | 3-Methoxycarbonylphenylboronic acid
99769-19-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 3-Methoxycarbonylphenylboronic acid
99769-19-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3-Methoxycarbonylphenylboronic acid
99769-19-4
- $1.20-34.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-Methoxycarbonylphenylboronic acid
99769-19-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 3-Methoxycarbonylphenylboronic acid
99769-19-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
