Hydroxocobalamin
- CAS No.
- 13422-51-0
- Chemical Name:
- Hydroxocobalamin
- Synonyms
- hydroxycobalamin;HYDROXOCOBALAMINE;axion;Depovit B12;hydroxycobalamine;VITAMIN B12A HYDROCHLORIDE;HYDROXOCOBALAMIN VITAMIN B12;HYDROXYCOBALAMIN HYDROCHLORIDE;axlon;ohb12
- CBNumber:
- CB6133733
- Molecular Formula:
- C62H90ClCoN13O15P
- Molecular Weight:
- 1382.82
- MDL Number:
- MFCD09029250
- MOL File:
- 13422-51-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Hydroxocobalamin European Pharmacopoeia (EP) Reference Standard | H1428000 | 15 mg | $254 |
| Hydroxocobalamin European Pharmacopoeia (EP) Reference Standard | H1428000 | h1428000 | $220 |
| Hydroxocobalamin ≥90% | 24099 | 5mg | $53 |
| Hydroxocobalamin ≥90% | 24099 | 10mg | $98 |
| Hydroxocobalamin ≥90% | 24099 | 25mg | $231 |
| More product size | |||
| Melting point | >300 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | methanol: 10 mg/mL at 20 °C, clear, dark red |
| form | Solid |
| color | Dark Brown to Black |
| Odor | odorless |
| Stability | Hygroscopic |
| Major Application | pharmaceutical (small molecule) |
| InChIKey | YOZNUFWCRFCGIH-ZKJXODNJNA-K |
| LogP | -2.812 (est) |
| FDA UNII | Q40X8H422O |
| ATC code | B03BA03,B03BA53,V03AB33 |
| EPA Substance Registry System | Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3) (13422-51-0) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Hazard Codes | Xi |
|---|---|
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | GG3820000 |
| F | 3-8-10 |
| TSCA | TSCA listed |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 13422-51-0(Hazardous Substances Data) |
| Toxicity | LD50 intravenous in mouse: > 50mg/kg |
Hydroxocobalamin price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H1428000 | Hydroxocobalamin European Pharmacopoeia (EP) Reference Standard | 13422-51-0 | 15 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | H1428000 | Hydroxocobalamin European Pharmacopoeia (EP) Reference Standard | 13422-51-0 | h1428000 | $220 | 2024-03-01 | Buy |
| Cayman Chemical | 24099 | Hydroxocobalamin ≥90% | 13422-51-0 | 5mg | $53 | 2026-04-30 | Buy |
| Cayman Chemical | 24099 | Hydroxocobalamin ≥90% | 13422-51-0 | 10mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 24099 | Hydroxocobalamin ≥90% | 13422-51-0 | 25mg | $231 | 2026-04-30 | Buy |
Hydroxocobalamin Chemical Properties,Uses,Production
Uses
Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate; a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).
Originator
Alpha-Redisol,MSD,US,1962
Uses
Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin(N490240) is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate (H826800); a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).
Definition
A form of vitamin B 12.
Manufacturing Process
A solution containing 26.3 mg of vitamin B12 in 15 ml of water was shaken
with 78 mg of platinum oxide catalyst and hydrogen gas under substantially
atmospheric pressure at 25°C for 20 hours. Hydrogen was absorbed. During
the absorption of hydrogen the color of the solution changed from red to
brown. The solution was separated from the catalyst and evaporated to
dryness in vacuo. The residue was then dissolved in 1 ml of water and then
diluted with about 6 ml of acetone.
After standing for several hours a small amount of precipitate (about 2 to 3
mg) was formed and was then separated from the solution. This solution was
diluted with an additional 2 ml of acetone and again allowed to stand for
several hours. During this time about 4 to 5 mg of noncrystalline precipitate
formed. This solid was separated from the solution and an additional 2 ml of
acetone was added to the solution. On standing, vitamin B12a began to
crystallize in the form of red needles. After standing for 24 hours, the
crystalline material was separated, yield 12 mg. By further dilution of the
mother liquor with acetone additional crystalline precipitate formed (from US
Patent 2,738,302).
Therapeutic Function
Hematopoietic vitamin
Side effects
Hydroxocobalamin is generally a well-tolerated drug. The adverse effects stem from hypersensitivity reactions to cobalt or other components of the hydroxocobalamin injection. These adverse effects include; exanthema (rash), Itching, fever, nausea, dizziness, rigors, and hot flushes. Anaphylaxis is rare.
Hydroxocobalamin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6339 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 1168 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | 029-84385017; +8613259417953 | sales@pioneerbiotech.com | China | 1286 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| Lotusland Life Sciences | +8615821988213 | info@longyupharma.com | China | 2411 | 58 |
| Hefei Hangang Pharmaceutical Technology Co., Ltd. | +8618062405514 | ada@ipurechemical.com | China | 10224 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15050 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +86-18627785180 | info@finetechnology-ind.com | China | 9539 | 58 |
View Lastest Price from Hydroxocobalamin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Hydroxocobalamin
13422-51-0
|
$100.00 | 1KG | 99%min | 200TON | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-05-26 | Hydroxocobalamin
13422-51-0
|
$120.00 | 1kg | 0.99 | 1000000 | Hebei Fengjia New Material Co., Ltd | |
 |
2024-04-22 | Hydroxocobalamin
13422-51-0
|
$10.00 | 1kg | 99.912% | 10ton | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- Hydroxocobalamin
13422-51-0
- $100.00
- 99%min
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Hydroxocobalamin
13422-51-0
- $120.00
- 0.99
- Hebei Fengjia New Material Co., Ltd
-
- Hydroxocobalamin
13422-51-0
- $10.00
- 99.912%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
