Lipid A4
- CAS No.
- 2639634-71-0
- Chemical Name:
- Lipid A4
- Synonyms
- C12-4;Lipid A4;DSPE-PSar28-Mal;C12-4 (Lipid A4,Lipid A-4)
- CBNumber:
- CB613741828
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
Lipid A4 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 38351 | Lipid A4 ≥95% | 2639634-71-0 | 1mg | $82 | 2026-04-30 | Buy |
| Cayman Chemical | 38351 | Lipid A4 ≥95% | 2639634-71-0 | 5mg | $304 | 2026-04-30 | Buy |
| Cayman Chemical | 38351 | Lipid A4 ≥95% | 2639634-71-0 | 10mg | $445 | 2026-04-30 | Buy |
| BroadPharm | bp-41403 | Lipid A4 (solution in ethanol) | 2639634-71-0 | 1MG | $150 | 2026-05-24 | Buy |
| BroadPharm | bp-41403 | Lipid A4 (solution in ethanol) | 2639634-71-0 | 5MG | $430 | 2026-05-24 | Buy |
Lipid A4 Chemical Properties, Uses, Production
Description
Lipid A4 is a branched-chain ionizable cationic lipidoid that has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA.1 LNPs containing lipid A4 and encapsulating an mRNA reporter accumulate in the uterus, placenta, and ovaries, as well as to the spleen and liver, in pregnant mouse dams unlike LNPs containing the branched-chain ionizable cationic lipidoid C12-200 (Item No. 36699), which primarily accumulate in the liver. Intravenous administration of LNPs containing lipid A4 and encapsulating mRNA encoding VEGF increase placental VEGFR1 levels and mean fetal blood vessel area without inducing liver damage in pregnant mouse dams. LNPs containing lipid A4 and encapsulating mRNA encoding a chemiluminescent reporter cross the blood-brain barrier and induce reporter expression in the brains of mice.2WARNING This product is not for human or veterinary use.
References
[1] KELSEY L. SWINGLE, MICHAEL J. MITCHELL* Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy[J]. Journal of the American Chemical Society, 2023, 145 8: 4691-4706. DOI: 10.1021/jacs.2c12893
[2] EMILY L. HAN, MICHAEL J. MITCHELL* Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood–Brain Barrier Transfection and Crossing[J]. Nano Letters, 2024, 24 5: 1477-1486. DOI: 10.1021/acs.nanolett.3c03509
Lipid A4 Preparation Products And Raw materials
Raw materials
Preparation Products
Lipid A4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shochem(Shanghai)Co.,Ltd | +86-021-51783479 13816874662 | info@shochem.com | China | 300 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shochem(Shanghai)Co.,Ltd | +86-021-50800795 13816874662 | info@shochem.com | China | 500 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 38923 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
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