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ChemicalBook >> CAS DataBase List >>2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol

2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol

2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol Structure
2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol structure
CAS No.
2447607-85-2
Chemical Name:
2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol
Synonyms
ALK-IN-26;2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol
CBNumber:
CB613777980
Molecular Formula:
C24H23NO3S
Molecular Weight:
405.51
MDL Number:
MOL File:
2447607-85-2.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
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2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol Properties

Boiling point 611.4±57.0 °C(Predicted)
Density 1.22±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka 10.69±0.25(Predicted)
form Solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0901124 ALK-IN-26 99.87% 2447607-85-2 5mg $106 2026-06-04 Buy
ChemScene CS-0901124 ALK-IN-26 99.87% 2447607-85-2 10mg $162 2026-06-04 Buy
ChemScene CS-0901124 ALK-IN-26 99.87% 2447607-85-2 25mg $314 2026-06-04 Buy
ChemScene CS-0901124 ALK-IN-26 99.87% 2447607-85-2 50mg $498 2026-06-04 Buy
ApexBio Technology BA3395 ALK-IN-26 2447607-85-2 5mg $88 2026-05-06 Buy
Product number Packaging Price Buy
CS-0901124 5mg $106 Buy
CS-0901124 10mg $162 Buy
CS-0901124 25mg $314 Buy
CS-0901124 50mg $498 Buy
BA3395 5mg $88 Buy

2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol Chemical Properties, Uses, Production

Uses

ALK-IN-26 is an ALK inhibitor with IC50 value of 7.0 μM for ALK tyrosine kinase. ALK-IN-26 has good pharmacokinetic properties and blood-brain barrier (BBB) permeability. ALK-IN-26 can induce apoptosis, autophagy and necrosis. ALK-IN-26 can be used in glioblastoma studies[1].

in vivo

ALK-IN-26 (5 mg/kg, i.v., single dose) has pharmacokinetic properties in male C57BL6/J mice[1].
ALK-IN-26 is (20 mg/kg, i.p., single dose) able to penetrate the blood-brain barrier in male C57BL6/J mice[1].

Pharmacokinetic parameters of C57BL6/J in male rats (n = 3) [1]

Pharmacokinetic propertyT1/2(h)Tmax(h) Cmax (ng/mL)AUC(0-8) (h*ng/mL)AUC(0-∞) (h*ng/mL)MRT(0-8) (h)MRT(0-∞) (h)V∞ (L/kg)V2 (L/kg)bioavailablity F (%)
i.v.(5mg/kg)1.130.081978.21884.88924.560.630.844.598.8938.40
i.p.(5mg/kg)3.550.58117.57339.79420.502.254.60///
Animal Model:Male C57BL/6J mice[1]
Dosage:5 mg/kg
Administration:Intravenous injection (i.v.), Single dose
Result:Could be rapidly absorbed (Tmax = 0.58 h) with an acceptable half-life (T1/2 = 3.55 h) and bioavailability (F = 38.4%).
Animal Model:Male C57BL/6J mice[1]
Dosage:20mg/kg
Administration:Intraperitoneal injection (i.p.), Single dose
Result:Could enter the body at concentrations up to 2.7μmol/kg (after 2 h administration at 20 mg/kg) and penetrate the blood-brain barrier.

References

[1] Feng L, et al. Synthesis and Bioevaluation of 3-(Arylmethylene) indole Derivatives: Discovery of a Novel ALK Modulator with Antiglioblastoma Activities[J]. Journal of Medicinal Chemistry, 2023. DOI:10.1021/acs.jmedchem.3c01090

2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol Preparation Products And Raw materials

Raw materials

Preparation Products

2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol Suppliers

Global Suppliers ( 7)
Supplier Tel Email Country ProdList Advantage
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
Zhejiang Huida Biotech Co., Ltd. 0571-89903022 18679456698 zilong@hizyme.com China 7853 58
Supplier Advantage
Shanghai Chaolan Chemical Technology Center 58
TargetMol Chemicals Inc. 58
Bide Pharmatech Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Amole Biotechnology Co., Ltd. 58
Zhejiang Huida Biotech Co., Ltd. 58

View Latest Price from 2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ALK-IN-26 pictures 2026-07-27 ALK-IN-26
2447607-85-2
 $35.00-79.00 99.91% 10g TargetMol Chemicals Inc.
  • ALK-IN-26 pictures
  • ALK-IN-26
    2447607-85-2
  • $35.00-79.00
  • 99.91%
  • TargetMol Chemicals Inc.

2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol Spectrum

2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol(2447607-85-2)1HNMR

2447607-85-2 (2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol) Related Search:

1H-Indole-3-carboxaldehyde, 6-methoxy-1-[(4-methoxyphenyl)sulfonyl]- 1H-Indole, 4-bromo-3-methyl-1-(phenylsulfonyl)- Ethanone, 1-[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]- 1H-Pyrrole, 3-ethyl-1-(phenylsulfonyl)- N-(benzenesulfonyl)indole-3-carbonitrile
1H-Indole, 3-(4-methoxyphenyl)-1-(phenylsulfonyl)-

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2,6-Dimethyl-4-[[1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]methyl]phenol ALK-IN-26 2447607-85-2