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Thiotriazinone

Thiotriazinone structure

CAS No.: 58909-39-0

Chemical Name:: Thiotriazinone

Synonyms: Ceftriaxone Triazine Analog;Ro 11-8390;TTZ,TTA,OHMMT;Triazine acid;THIOTRIAZINONE;Thiotriazinone(TTZ);Thiotriazinone, 98+%;Ceftriaxone EP Impurity C;Ceftriaxone Sodium USP Impurity D;2-AMINOPROPYL-4(7)-AZO-BENZIMIDAZOLE

CBNumber:: CB6138905

Molecular Formula:: C4H5N3O2S

Molecular Weight:: 159.17

MDL Number:: MFCD00185756

MOL File:: 58909-39-0.mol

MSDS File:: SDS

Last updated:2026-05-28 01:27:34

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Thiotriazinone Properties

Melting point	168-171 °C (lit.)
Density	1.62±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Sparingly), Methanol (Slightly)
form	Solid
pka	5.34±0.20(Predicted)
color	White to Off-White
InChI	InChI=1S/C4H5N3O2S/c1-7-4(10)5-2(8)3(9)6-7/h1H3,(H,6,9)(H,5,8,10)
InChIKey	UMWWHOXOVPIGFD-UHFFFAOYSA-N
SMILES	N1C(=O)C(=O)NC(=S)N1C
CAS DataBase Reference	58909-39-0(CAS DataBase Reference)
FDA UNII	679WF9Q9W1
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

20/21/22-36

Safety Statements

36-26

WGK Germany

HS Code

29336990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2

REACH Registrations

Active

NFPA 704

	1
0		0

Thiotriazinone price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	549746	Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione 97%	58909-39-0	25g	$440	2026-04-30	Buy
Usbiological	021795	Thiotriazinone	58909-39-0	100mg	$403	2026-06-03	Buy
aablocks	AA003UM2	2-Methyl-3-thioxo-1,2,4-triazinane-5,6-dione 98%	58909-39-0	1g	$8	2026-05-28	Buy
aablocks	AA003UM2	2-Methyl-3-thioxo-1,2,4-triazinane-5,6-dione 98%	58909-39-0	5g	$10	2026-05-28	Buy
aablocks	AA003UM2	2-Methyl-3-thioxo-1,2,4-triazinane-5,6-dione 98%	58909-39-0	25g	$32	2026-05-28	Buy

Product number	Packaging	Price	Buy
549746	25g	$440	Buy
021795	100mg	$403	Buy
AA003UM2	1g	$8	Buy
AA003UM2	5g	$10	Buy
AA003UM2	25g	$32	Buy

Thiotriazinone Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Reagent used in the preparation of Cefalosporins.

Uses

Thiotriazinone can be used in the preparation of Cefalosporins.

General Description

Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione is an intermediate for synthesizing ceftriaxone.

Synthesis

6938-68-7

95-92-1

58909-39-0

General procedure for the synthesis of triazine ring from 2-methylaminothiourea and diethyl oxalate: 2-methylaminothiourea, mixed solvent (1:3 mass ratio of methanol to DMSO), diethyl oxalate and sodium methanolate were added to the reactor in the mass ratio 1:10:4:10. The cyclization reaction was carried out in the temperature range of 0-45°C. Upon completion of the reaction, acidification was carried out with hydrochloric acid in an amount of 30% by mass of 2-methylaminothiourea. Subsequently, the reaction mixture was filtered and dried to give the triazine ring in 91.6% yield. The purity of the product was assayed by HPLC and the by-product content was 0.0005% (5 ppm). The product was calculated as M (triazine ring) / [M (methylaminothiourea) * 159.17 / 105.16].

References

[1] Patent: CN104177305, 2017, B. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026; 0027; 0028-0031

Thiotriazinone synthesis

Synthesis of Thiotriazinone from 2-Methyl-3-thiosemicarbazide and Diethyl oxalate

Thiotriazinone Preparation Products And Raw materials

Raw materials

2-Methyl-3-thiosemicarbazide Diethyl oxalate Methylhydrazine Sodium Methoxide Dimethyl oxalate

Dimethyl sulfoxide

1of2

Preparation Products

CEFTRIAXONE

Thiotriazinone Suppliers

Global( 265)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Taizhou Huaxi Technology Co. LTD	0576-89164227 13105618688	18323010@qq.com	China	39	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6746	52
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57

Supplier	Advantage
Taizhou Huaxi Technology Co. LTD	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Energy Chemical	61
Adamas Reagent, Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
XiaoGan ShenYuan ChemPharm co,ltd	52
Tianjin heowns Biochemical Technology Co., Ltd.	57

View Lastest Price from Thiotriazinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	Thiotriazinone 58909-39-0		1KG	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-20	Thiotriazinone 58909-39-0	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-03-12	Thiotriazinone 58909-39-0		10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD

Thiotriazinone
58909-39-0
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Thiotriazinone
58909-39-0
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

Thiotriazinone
58909-39-0
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

Thiotriazinone Spectrum

Thiotriazinone(58909-39-0)¹HNMR

58909-39-0(Thiotriazinone)Related Search:

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Methylparaben Kresoxim-methyl (E)-Ceftriaxone S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate Tetramethylpyrazine

1,3,5-Triazine Ceftriaxone Sodium Chlorophosphonazo III (6R-trans)-7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Methyl

Methyl bromide Malathion CEFTRIAXONE

1of4

2,5-Dihydro-6-hydroxy-3-mercapto-2-methyl-1,2,4-triazine-5-one TTZ,TTA,OHMMT Thiotriazinone(TTZ) 3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE[TTZ,OHMMT] 2,5-DIHYDRO-3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE Thiotriazinone, 98+% 2,5-DIHYDRO-3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE/TTZ THIOTRIAZINONE/2,5-DIHYDRO-6-HYDROXY-3-MERCAPTO-2-METHYL-5-OXO-1,2,4-TRIAZINE 2-METHYL-3-THIOXOHEXAHYDRO-1,2,4-TRIAZINE-5,6-DIONE(THIOTRIAZINONE) 1,2,4-Triazine-5,6-dione,tetrahydro-2-methyl-3-thioxo- 2-Methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazine-3-thiol 2,5-Dihydro-6-hydroxy-2-methyl-3-mercapto-5-oxo-1,2,3-triazine 2,5-Dihydro-6-hydroxy-2-methyl-3-mercapto-5-oxo-1,2,4-triazione 2-AMINOPROPYL-4(7)-AZO-BENZIMIDAZOLE 3-Mercapto-2-methyl-5-oxo-6-hydroxy-1,2,4-triazine Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione THIOTRIAZINONE (3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE) 2-METHYL-3-THIOXO-1,2,5,6-TETRAHYDRO-5,6-DIOXO-1,2,4-TRIAZINE 2-METHYL-5,6-DIOXO-1,2,5,6-TETRAHYDRO-1,2,4-TRIAZINE-3-THIOLCEFATRIAXONE 2-Methyl-3-thioxo-1,2,3,4-tetrahydro-1,2,4-triazine-5,6-dione Ceftriaxone EP Impurity C 3-mercapto-2-methyl-1H-triazin-3-ium-5,6-dione 5,6-dihydro-2H-1,2,3,4-thiatriazin-5-one Ro 11-8390 Ceftriaxone Impurity 3(Ceftriaxone EP Impurity C) 2-Methyl-3-thioxo-1,2,4-triazinane-5,6-dione 2,5-Dihydro-6-Hydroxy-3-Mercapto-2-Methyl-5-oxo-1,2,4-Triazine (TTZ) THIOTRIAZINONE 3-mercapto-2-methyl-1,2-dihydro-1,2,4-triazine-5,6-dione TTN 6-Hydroxy-3-Mercapto-2-Methyl-5-oxo-1,2,4-Triazine 3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE USP/EP/BP 2-Methyl-3-sulphanyl-1,2-dihydro-1,2,4-triazin-5,6-dione Ceftriaxone Sodium USP Impurity D 2-methyl-3-sulfanylidene-1,2,4-triazinane-5,6-dione Cefazolin oxidation impurities ( TBZL-Na-YH) 2-Methyl-3-sulfanyl-1,2-dihydro-1,2,4-triazine-5,6-dione Triazine acid Ceftriaxone Triazine Analog 58909-39-0 Building Blocks Heterocyclic Building Blocks Triazines Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Building Blocks Heterocyclic Building Blocks Triazines