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Thiotriazinone

Thiotriazinone structure

CAS No.: 58909-39-0

Chemical Name:: Thiotriazinone

Synonyms: Ro 11-8390;TTZ,TTA,OHMMT;Triazine acid;THIOTRIAZINONE;Thiotriazinone(TTZ);Thiotriazinone, 98+%;Ceftriaxone EP Impurity C;Ceftriaxone Triazine Analog;Ceftriaxone Sodium USP Impurity D;2-AMINOPROPYL-4(7)-AZO-BENZIMIDAZOLE

CBNumber:: CB6138905

Molecular Formula:: C4H5N3O2S

Molecular Weight:: 159.17

MDL Number:: MFCD00185756

MOL File:: 58909-39-0.mol

MSDS File:: SDS

Last updated:2026-05-28 01:27:34

Product description	Number	Pack Size	Price
Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione 97%	549746	25g	$440
2-Methyl-3-thioxo-1,2,4-triazinane-5,6-dione 95+%	CD11098899	25g	$84
2-Methyl-3-thioxo-1,2,4-triazinane-5,6-dione 95+%	CD11098899	100g	$276
2-methyl-3-sulfanylidene-1,2,4-triazinane-5,6-dione 95%+	CM344941	100g	$145
2-methyl-3-sulfanylidene-1,2,4-triazinane-5,6-dione 95%+	CM344941	500g	$509
More product size

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Thiotriazinone Properties

Melting point	168-171 °C (lit.)
Density	1.62±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Sparingly), Methanol (Slightly)
form	Solid
pka	5.34±0.20(Predicted)
color	White to Off-White
InChI	InChI=1S/C4H5N3O2S/c1-7-4(10)5-2(8)3(9)6-7/h1H3,(H,6,9)(H,5,8,10)
InChIKey	UMWWHOXOVPIGFD-UHFFFAOYSA-N
SMILES	N1C(=O)C(=O)NC(=S)N1C
CAS DataBase Reference	58909-39-0(CAS DataBase Reference)
FDA UNII	679WF9Q9W1
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

20/21/22-36

Safety Statements

36-26

WGK Germany

HS Code

29336990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2

REACH Registrations

Active

NFPA 704

	1
0		0

Thiotriazinone price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	549746	Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione 97%	58909-39-0	25g	$440	2026-04-30	Buy
Crysdot	CD11098899	2-Methyl-3-thioxo-1,2,4-triazinane-5,6-dione 95+%	58909-39-0	25g	$84	2026-05-26	Buy
Crysdot	CD11098899	2-Methyl-3-thioxo-1,2,4-triazinane-5,6-dione 95+%	58909-39-0	100g	$276	2026-05-26	Buy
Chemenu	CM344941	2-methyl-3-sulfanylidene-1,2,4-triazinane-5,6-dione 95%+	58909-39-0	100g	$145	2026-05-26	Buy
Chemenu	CM344941	2-methyl-3-sulfanylidene-1,2,4-triazinane-5,6-dione 95%+	58909-39-0	500g	$509	2026-05-26	Buy

Product number	Packaging	Price	Buy
549746	25g	$440	Buy
CD11098899	25g	$84	Buy
CD11098899	100g	$276	Buy
CM344941	100g	$145	Buy
CM344941	500g	$509	Buy

Thiotriazinone Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Reagent used in the preparation of Cefalosporins.

Uses

Thiotriazinone can be used in the preparation of Cefalosporins.

General Description

Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione is an intermediate for synthesizing ceftriaxone.

Synthesis

6938-68-7

95-92-1

58909-39-0

General procedure for the synthesis of triazine ring from 2-methylaminothiourea and diethyl oxalate: 2-methylaminothiourea, mixed solvent (1:3 mass ratio of methanol to DMSO), diethyl oxalate and sodium methanolate were added to the reactor in the mass ratio 1:10:4:10. The cyclization reaction was carried out in the temperature range of 0-45°C. Upon completion of the reaction, acidification was carried out with hydrochloric acid in an amount of 30% by mass of 2-methylaminothiourea. Subsequently, the reaction mixture was filtered and dried to give the triazine ring in 91.6% yield. The purity of the product was assayed by HPLC and the by-product content was 0.0005% (5 ppm). The product was calculated as M (triazine ring) / [M (methylaminothiourea) * 159.17 / 105.16].

References

[1] Patent: CN104177305, 2017, B. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026; 0027; 0028-0031

Thiotriazinone synthesis

Synthesis of Thiotriazinone from 2-Methyl-3-thiosemicarbazide and Diethyl oxalate

Thiotriazinone Preparation Products And Raw materials

Raw materials

2-Methyl-3-thiosemicarbazide Diethyl oxalate Methylhydrazine Sodium Methoxide Dimethyl oxalate

Dimethyl sulfoxide

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Preparation Products

CEFTRIAXONE

Thiotriazinone Suppliers

Global( 256)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Shandong Xuhuang New material CoLTD	+86-15095020839 +86-17660422208		China	726	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2988	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
airuikechemical co., ltd.	58
Shandong Xuhuang New material CoLTD	58
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
SIMAGCHEM CORP	58

View Lastest Price from Thiotriazinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-27	Thiotriazinone 58909-39-0	US $0.00-0.00 / Kg/Drum	1KG	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-20	Thiotriazinone 58909-39-0	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-03-12	Thiotriazinone 58909-39-0	US $0.00-0.00 / mg	10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD

Thiotriazinone
58909-39-0
US $0.00-0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Thiotriazinone
58909-39-0
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Thiotriazinone
58909-39-0
US $0.00-0.00 / mg
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

Thiotriazinone Spectrum

Thiotriazinone(58909-39-0)¹HNMR

58909-39-0(Thiotriazinone)Related Search:

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Methyl acrylate Methylparaben Kresoxim-methyl Tetramethylpyrazine S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate

(E)-Ceftriaxone 1,3,5-Triazine Ceftriaxone Sodium (6R-trans)-7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Methyl

Methyl bromide Malathion CEFTRIAXONE

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2,5-Dihydro-6-hydroxy-3-mercapto-2-methyl-1,2,4-triazine-5-one TTZ,TTA,OHMMT Thiotriazinone(TTZ) 3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE[TTZ,OHMMT] 2,5-DIHYDRO-3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE Thiotriazinone, 98+% 2,5-DIHYDRO-3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE/TTZ THIOTRIAZINONE/2,5-DIHYDRO-6-HYDROXY-3-MERCAPTO-2-METHYL-5-OXO-1,2,4-TRIAZINE 2-METHYL-3-THIOXOHEXAHYDRO-1,2,4-TRIAZINE-5,6-DIONE(THIOTRIAZINONE) 1,2,4-Triazine-5,6-dione,tetrahydro-2-methyl-3-thioxo- 2-Methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazine-3-thiol 2,5-Dihydro-6-hydroxy-2-methyl-3-mercapto-5-oxo-1,2,3-triazine 2,5-Dihydro-6-hydroxy-2-methyl-3-mercapto-5-oxo-1,2,4-triazione 2-AMINOPROPYL-4(7)-AZO-BENZIMIDAZOLE 3-Mercapto-2-methyl-5-oxo-6-hydroxy-1,2,4-triazine Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione THIOTRIAZINONE (3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE) 2-METHYL-3-THIOXO-1,2,5,6-TETRAHYDRO-5,6-DIOXO-1,2,4-TRIAZINE 2-METHYL-5,6-DIOXO-1,2,5,6-TETRAHYDRO-1,2,4-TRIAZINE-3-THIOLCEFATRIAXONE 2-Methyl-3-thioxo-1,2,3,4-tetrahydro-1,2,4-triazine-5,6-dione Ceftriaxone Triazine Analog Ceftriaxone EP Impurity C 3-mercapto-2-methyl-1H-triazin-3-ium-5,6-dione 5,6-dihydro-2H-1,2,3,4-thiatriazin-5-one Ro 11-8390 Ceftriaxone Impurity 3(Ceftriaxone EP Impurity C) 2-Methyl-3-thioxo-1,2,4-triazinane-5,6-dione 2,5-Dihydro-6-Hydroxy-3-Mercapto-2-Methyl-5-oxo-1,2,4-Triazine (TTZ) THIOTRIAZINONE 3-mercapto-2-methyl-1,2-dihydro-1,2,4-triazine-5,6-dione TTN 6-Hydroxy-3-Mercapto-2-Methyl-5-oxo-1,2,4-Triazine 3-MERCAPTO-2-METHYL-5-OXO-6-HYDROXY-1,2,4-TRIAZINE USP/EP/BP 2-Methyl-3-sulphanyl-1,2-dihydro-1,2,4-triazin-5,6-dione Ceftriaxone Sodium USP Impurity D 2-methyl-3-sulfanylidene-1,2,4-triazinane-5,6-dione Cefazolin oxidation impurities ( TBZL-Na-YH) 2-Methyl-3-sulfanyl-1,2-dihydro-1,2,4-triazine-5,6-dione Triazine acid 58909-39-0 Building Blocks Heterocyclic Building Blocks Triazines Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Building Blocks Heterocyclic Building Blocks Triazines