N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride
- CAS No.
- 149409-57-4
- Chemical Name:
- N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride
- Synonyms
- NE-100;NE100 HCl;NE100;NE 100;NE 100 hydrochloride;4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanaMine;4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanaminehydrochloride;N,N-Di-n-propyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl] ethylamine hydrochloride;N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride;NE100 hydrochloride?,NE100,inhibit,Inhibitor,NE 100 hydrochloride?,Sigma Receptor,NE 100,NE-100
- CBNumber:
- CB61400997
- Molecular Formula:
- C23H33NO2.HCl
- Molecular Weight:
- 0
- MDL Number:
- MFCD00922105
- MOL File:
- 149409-57-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 94-96°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble15mg/mL, clear |
| form | powder |
| color | white to beige |
| Water Solubility | H2O: 15mg/mL, clear |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| InChI | 1S/C21H29NO2.ClH/c1-4-22(5-2)15-13-19-11-12-20(23-3)21(17-19)24-16-14-18-9-7-6-8-10-18;/h6-12,17H,4-5,13-16H2,1-3H3;1H |
| InChIKey | LPMIMPZUXJWRJJ-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19642 | NE 100 ≥98% | 149409-57-4 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 19642 | NE 100 ≥98% | 149409-57-4 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 19642 | NE 100 ≥98% | 149409-57-4 | 10mg | $169 | 2026-04-30 | Buy |
| Cayman Chemical | 19642 | NE 100 ≥98% | 149409-57-4 | 25mg | $378 | 2026-04-30 | Buy |
| Usbiological | 460619 | NE 100 Hydrochloride | 149409-57-4 | 1mg | $602 | 2026-06-03 | Buy |
N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Chemical Properties, Uses, Production
Description
NE-100 (149409-57-4) is potent inhibitor of the sigma receptor (σ) with selectivity for sigma-1 (IC50= 1.5 nM) over sigma-2 (IC50= 85 nM).1,2NE-100 suppressed ischemia-induced neuronal cell death in miceviaupregulation of GRP78 through the ATF6 pathway resulting in suppression of ER stress-induced cell death in a sigma-1-independent manner.3
Uses
NE-100 is a potent and selective σ1 receptor antagonist.
Biological Activity
Potent and selective σ 1 receptor antagonist (K i = 0.86 nM) that displays > 55-fold selectivity over σ 2 receptors and > 6000-fold selectivity over D 1 , D 2 , 5-HT 1A , 5-HT 2 and PCP receptors. Exhibits reversible binding (K d = 1.2 nM) and displays antipsychotic activity in vivo . Orally active.
Biochem/physiol Actions
NE-100 is a potent and selective σ1 receptor antagonist with an IC50 value of 1.54 +/- 0.26 nM for σ1 receptors, > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors.
storage
Store at -20°C
References
[1] SHIGERU OKUYAMA . NE-100, a novel sigma receptor ligand: In vivo tests[J]. Life sciences, 1993, 53 18: Pages PL285-PL290. DOI:10.1016/0024-3205(93)90588-t
[2] NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain
[3] YOKO ONO. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells[J]. Biochemical and biophysical research communications, 2013, 434 4: Pages 904-909. DOI:10.1016/j.bbrc.2013.04.055
N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Chuangshuo Chemical Technology Co., Ltd | 180-62205282 18062205282 | turbo_cq@163.com | China | 34 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Changzhou Renaissance Chem Co. Ltd | 86-519-86202821 | China | 116 | 56 | |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5854 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9774 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
View Latest Price from N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | NE-100 hydrochloride
149409-57-4
|
$38.00-84.00 | 99.76% | 10g | TargetMol Chemicals Inc. |
-
- NE-100 hydrochloride
149409-57-4
- $38.00-84.00
- 99.76%
- TargetMol Chemicals Inc.
