Ginkgolide B
- CAS No.
- 15291-77-7
- Chemical Name:
- Ginkgolide B
- Synonyms
- BN 52021;BGinkgolid;GINKGOLIDE B;GINKGOLIDE B(SH);7-DEOXYGINKGOLIDE C;GINKOLIDE B;BN 52021;Ginkgolide B (BN-52021);Ginkgolide B (Standard);Ginkgolide B, 10 mM in DMSO;GinkgolideA,1-hydroxy-, (1β)-
- CBNumber:
- CB3745566
- Molecular Formula:
- C20H24O10
- Molecular Weight:
- 424.4
- MDL Number:
- MFCD05662347
- MOL File:
- 15291-77-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 280°C (dec.) |
|---|---|
| alpha | D24 -52.6° (c = 1 in ethanol) |
| Boiling point | 762.4±60.0 °C(Predicted) |
| Density | 1+-.0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml). |
| form | Solid |
| pka | pKa1 7.14; pKa2 8.60; pKa3 11.89(at 25℃) |
| color | White |
| Water Solubility | Soluble in DMSO. Slightly soluble in water and ethanol |
| BRN | 4727611 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| InChIKey | SQOJOAFXDQDRGF-MMQTXUMRSA-N |
| SMILES | [C@@]12(O)[C@]34C(=O)O[C@@H]5C[C@@H](C(C)(C)C)C6([C@@H](O)C(=O)O[C@@]6([H])O3)C45[C@H](O)[C@]1([H])OC(=O)[C@H]2C |
| LogP | 2.070 (est) |
| CAS DataBase Reference | 15291-77-7(CAS DataBase Reference) |
| FDA UNII | DF149B9460 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 29322090 | |||||||||
| NFPA 704 |
|
Ginkgolide B price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G6910 | Ginkgolide B from Ginkgo biloba leaves ≥90% (HPLC) | 15291-77-7 | 10mg | $146 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHL89205 | Ginkgolide B phyproof? Reference Substance | 15291-77-7 | 10MG | $211 | 2026-04-30 | Buy |
| Sigma-Aldrich | 94970 | Ginkgolide B analytical standard | 15291-77-7 | 10mg | $269 | 2026-04-30 | Buy |
| TCI Chemical | G0553 | Ginkgolide B | 15291-77-7 | 25MG | $58 | 2026-04-30 | Buy |
| TCI Chemical | G0553 | Ginkgolide B | 15291-77-7 | 100MG | $172 | 2026-04-30 | Buy |
Ginkgolide B Chemical Properties, Uses, Production
Description
Ginkgolide B is an important active ingredient derived from the leaf extract of Ginkgo biloba (Ginkgo biloba leaf extract, GBLPE), a member of the Ginkgoaceae family. It belongs to the class of terpenoid ketones and is a diterpene trilactone containing six five-membered rings in its molecular structure. The molecule comprises a spiro[4.4]nonane skeleton and a tetrahydrofuran ring, and is readily soluble in solvents such as ethyl acetate, methanol, ethanol, and dimethyl sulfoxide.
Chemical Properties
White Crystalline Solid
History
The leaf of Ginkgo biloba is sweet, bitter, astringent, and mild. With activating
blood circulation to remove blood stasis, dredging collaterals, relieving pain, and
asthma, it is applied for treating blood stasis, chest pain, stroke, lung deficiency
cough, and hyperlipidemia.
As early as in the 1930s, scientists began to study ginkgo and harvest a variety of
ginkgolide . Ginkgolide B was isolated and its structure illustrated by Wan Shan
etal. in 1967. Subsequently, it was synthesized by Corey etal. in 1988. The
preparation of effective components of Ginkgo biloba has been listed at home and
abroad with development.
The Ginkgo biloba extract consisting of ticlopidine is widely used in overseas
market for the treatment of cerebral infarction. Intravenous injection of ginkgolide
B is applied for the treatment of inflammation, but the project has been in the state,
and there is no progress in it for many years. In addition, whether other extract of
Ginkgo biloba can be used for the treatment of stable angina, cognitive impairment
is still in preclinical research status.
Uses
Family of bioactive terpenes treating cardiovascular and cerebrovascular diseases. Specific platelet activating factor (PAF) antagonists
Uses
Ginkgolide B is used as a potent PAF-R antagonist. Ginkgolide B speeds up PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. Additionally, this compound has been reported to inhibit neutrophil degranulation in vitro. Inhibits superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.
Indications
The injection consists of multiple components, and there are three kinds of substance mainly in diterpene ginkgolides meglumine injection. It promotes blood circulation by removing blood stasis and activates the channels and collaterals for cerebral ischemia treatment.
Biological Activity
Platelet-activating factor (PAF) receptor antagonist (K i = 1.3 μ M). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo .
Pharmacology
Ginkgolide B has a variety of pharmacological effects, mainly in cardiovascular and cerebrovascular protection and neuroprotection. On the one hand, with the strongest activity in nature, the platelet-activating factor (PAF) receptor antagonist is recognized by the public . PAF can inhibit the downstream inflammatory cascade for anti-inflammatory. It also can alleviate cerebral infraction volume and cerebral edema induced by cerebral ischemia among the animal model of cerebral ischemia reperfusion through unknown mechanism. By inhibiting NF-κB and TNF-α, the apoptosis of nerve cell can be alleviated. The compound protects the abdominal cavity and intestinal tract by inhibiting release of neutrophil chemotactic protein by macrophage.
Clinical Use
Oral and injection preparations are applied widely in clinical therapy. Made in oral preparation, flavonoids are the main component of raw material. There are little chemical compounds in injection, and ginkgolides are the main component whose content is different from each other. Listed ginkgolide injection is applied for ischemia stroke formed by blood stasis with promoting blood circulation by removing blood stasis and clearing and activating the channels and collaterals. Compared with Shuxuening injection in clinical trials, ginkgolides injection is consistent in improving indicators effect, such as protection in nerve injury and others.
target
p38MAPK | IkB | Syk | Calcium Channel | LDL | Nrf2 | Akt | JNK | MMP(e.g.TIMP) | Caspase | NF-kB | TNF-α | NOS | p53 | Bcl-2/Bax | IKK
References
[1] EVA FÜLDES-FILEP Janos F Pierre Braquet. Inhibition by BN 52021 (Ginkgolide B) of the binding of [3h]- Platelet-activating factor to human neutrophil granulocytes[J]. Biochemical and biophysical research communications, 1987, 148 3: Pages 1412-1417. DOI:10.1016/s0006-291x(87)80289-9
[2] STÉPHANIE DESQUAND . Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig[J]. European journal of pharmacology, 1986, 127 1: Pages 83-95. DOI:10.1016/0014-2999(86)90208-6
[3] KARYN M MACLENNAN Paul F S Cynthia L Darlington. The CNS effects of Ginkgo biloba extracts and ginkgolide B[J]. Progress in Neurobiology, 2002, 67 3: Pages 235-257. DOI:10.1016/s0301-0082(02)00015-1
[4] LE LI. Neuroprotective effect of ginkgolide B on bupivacaine-induced apoptosis in SH-SY5Y cells.[J]. Oxidative Medicine and Cellular Longevity, 2013: 159864. DOI:10.1155/2013/159864
[5] XUAN WANG. Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats[J]. Journal of Neuroscience Research, 2013, 92 2: 232-242. DOI:10.1002/jnr.23306
Ginkgolide B Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Dasf Biotechnology Co., Ltd. | 16651696448 | 1773155960@qq.com | China | 1990 | 58 |
| Nanjing Bencao Yikang Biotechnology Co., Ltd | 025-69790911 18362932668 | 522593521@qq.com | China | 1163 | 58 |
| Shanghai Yanchun Biopharmaceutical Technology Co., Ltd | 4001-009266 17349750668 | product@sci-e.com | China | 2808 | 58 |
| Nanjing bingcheng Biotechnology Co., Ltd. | 18805194892 | 2727751293@qq.com | China | 172 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
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View Latest Price from Ginkgolide B manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Ginkgolide B
15291-77-7
|
$57.00-97.00 | 99.81% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-12 | Ginkgolide B
15291-77-7
|
1kg | 98% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | ||
 |
2023-02-24 | Ginkgolide B
15291-77-7
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Ginkgolide B
15291-77-7
- $57.00-97.00
- 99.81%
- TargetMol Chemicals Inc.
-
- Ginkgolide B
15291-77-7
- $0.00
- 98%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Ginkgolide B
15291-77-7
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
