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2-CHLORO-4-PHENYLPYRIMIDINE

2-CHLORO-4-PHENYLPYRIMIDINE Structure
2-CHLORO-4-PHENYLPYRIMIDINE structure
CAS No.
13036-50-5
Chemical Name:
2-CHLORO-4-PHENYLPYRIMIDINE
Synonyms
2-CHLORO-4-PHENYLPYRIMIDINE;2-chloro-4-phenyl-pyrimidin;2-Chloro-6-phenylpyrimidine;2-Chloro-4-phenylpyrimidine95%;Pyrimidine, 2-chloro-4-phenyl-
CBNumber:
CB6141833
Molecular Formula:
C10H7ClN2
Molecular Weight:
190.63
MDL Number:
MFCD00234600
MOL File:
13036-50-5.mol
Last updated:2026-05-28 02:04:04
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2-CHLORO-4-PHENYLPYRIMIDINE Properties

Melting point 86 °C
Boiling point 368.3±11.0 °C(Predicted)
Density 1.245±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
pka -1.38±0.20(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-37/38-41
Safety Statements  26-39
HS Code  2933599590
NFPA 704
0
2 0

2-CHLORO-4-PHENYLPYRIMIDINE price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth NAA03650 2-Chloro-4-phenylpyrimidine 13036-50-5 10g $354 2026-06-04 Buy
Apolloscientific OR9304 2-Chloro-4-phenylpyrimidine 98% 13036-50-5 250mg $24 2026-06-04 Buy
Apolloscientific OR9304 2-Chloro-4-phenylpyrimidine 98% 13036-50-5 1g $73 2026-06-04 Buy
Apolloscientific OR9304 2-Chloro-4-phenylpyrimidine 98% 13036-50-5 5g $302 2026-06-04 Buy
Apolloscientific OR9304 2-Chloro-4-phenylpyrimidine 98% 13036-50-5 10g $559 2026-06-04 Buy
Product number Packaging Price Buy
NAA03650 10g $354 Buy
OR9304 250mg $24 Buy
OR9304 1g $73 Buy
OR9304 5g $302 Buy
OR9304 10g $559 Buy

2-CHLORO-4-PHENYLPYRIMIDINE Chemical Properties,Uses,Production

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 4137, 1988 DOI: 10.1021/jo00252a057

Synthesis

2,4-Dichloropyrimidine

3934-20-1

Phenylboronic acid

98-80-6

2-CHLORO-4-PHENYLPYRIMIDINE

13036-50-5

General procedure for the synthesis of 2-chloro-4-phenylpyrimidines from 2,4-dichloropyrimidines and phenylboronic acid: first, 2,4-dichloropyrimidines (5 g, 33.57 mmol) were dissolved in acetonitrile (60 ml), followed by the addition of water (15 ml). Next, phenylboronic acid (4.09 g, 33.57 mmol) and sodium carbonate (14.23 g, 134.28 mmol) were added to this solution. Degassing was carried out by blowing nitrogen into the reaction mixture for 10 minutes. After that, tetrakis(triphenylphosphine)palladium (354 mg, 0.34 mmol) was added. The reaction mixture was stirred under nitrogen protection at 90 °C for 18 hours. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was collected. The solvent was removed by distillation under reduced pressure and the crude product obtained was purified by column chromatography with the eluent being a 10-15% ethyl acetate/petroleum ether solvent mixture, resulting in the target compound 2-chloro-4-phenylpyrimidine as a colorless solid (2.98 g, 47% yield). Mass spectrum (LRMS) [M + H]+ m/z: 191.1; 1H NMR (400 MHz, CDCl3) δ 8.62 (d, J = 5.3 Hz, 1H), 8.16-7.99 (m, 2H), 7.63 (d, J = 5.3 Hz, 1H), 7.50 (qdd, J = 6.0,3.2,1.4 Hz, 3H).

References

[1] Journal of Organometallic Chemistry, 2018, vol. 862, p. 76 - 85
[2] Patent: CN103819455, 2016, B. Location in patent: Paragraph 0067; 0084; 0085
[3] Patent: KR2015/34146, 2015, A. Location in patent: Paragraph 0059; 0076; 0077
[4] Tetrahedron Letters, 2006, vol. 47, # 26, p. 4415 - 4418
[5] Patent: WO2011/93609, 2011, A1. Location in patent: Page/Page column 19

2-CHLORO-4-PHENYLPYRIMIDINE Preparation Products And Raw materials

Raw materials

2-PHENYLMALONDIALDEHYDE p-Toluenesulfonic acid Ethanol Sodium sulfate Phosphorus oxitrichloride
N,N-Dimethylaniline Diethyl ether Benzene Hydrochloric acid Sodium bicarbonate
Dichloromethane Sodium hydroxide Dimethylamine Magnesium sulfate UREA HYDROCHLORIDE
Sodium carbonate

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Preparation Products

2-CHLORO-4-PHENYLPYRIMIDINE Suppliers

Global( 92)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Thermo Fisher Scientific 800-810-5118 cnchemical@thermofisher.com China 17752 75
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9874 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 22497 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Thermo Fisher Scientific 75
Shanghai T&W Pharmaceutical Co., Ltd. 58
Nanjing Norris-Pharm Technology Co., Ltd 55
9ding chemical ( Shanghai) Limited 55

View Lastest Price from 2-CHLORO-4-PHENYLPYRIMIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-phenylpyriMidine pictures 2020-05-17 2-Chloro-4-phenylpyriMidine
13036-50-5
 $1.00 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
2-CHLORO-4-PHENYLPYRIMIDINE pictures 2020-01-09 2-CHLORO-4-PHENYLPYRIMIDINE
13036-50-5
 $6.68 1KG 99% 1kg-1000kg Career Henan Chemical Co

2-CHLORO-4-PHENYLPYRIMIDINE Spectrum

2-CHLORO-4-PHENYLPYRIMIDINE(13036-50-5)1HNMR

13036-50-5(2-CHLORO-4-PHENYLPYRIMIDINE)Related Search:

2-CHLORO-4-PHENYLPYRIMIDINE Ethyl 2-chloro-4-phenylpyrimidine-5-carboxylate ,97%,ETHYL 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBOXYLATE 4-(3-Bromophenyl)-2-chloropyrimidine 2-AMINO-4-CHLORO-6-PHENYLPYRIMIDINE 2-CHLORO-4-PHENYLPYRIMIDINE-5-CARBONYL CHLORIDE
2-CHLORO-5-(4-METHOXYPHENYL)PYRIMIDINE 4-PHENYLIMIDAZOLE 2-CHLORO-6-METHYL-4-PHENYL-QUINAZOLINE 2,4-dichloro-6-phenylpyrimidine 2,6-DICHLORO-4-PHENYL-QUINAZOLINE
2-chloro-5-methyl-4-phenylpyrimidine 2-Chloro-4-(4-fluoro-phenyl)-pyrimidine 2-CHLORO-4-PHENYLQUINAZOLINE 6-BROMO-2-CHLORO-4-PHENYLQUINAZOLINE 2-Chloro-4,6-diphenylpyrimidine
4-CHLORO-6-PHENYLPYRIMIDINE 5-CHLORO-2-PHENYLPYRIMIDINE 6-AMINO-2-(4-BROMOPHENYL)-5-CHLOROPYRIMIDINE-4-CARBOXYLIC ACID

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2-chloro-4-phenyl-pyrimidin 2-CHLORO-4-PHENYLPYRIMIDINE Pyrimidine, 2-chloro-4-phenyl- 2-Chloro-4-phenylpyrimidine95% 2-Chloro-6-phenylpyrimidine 13036-50-5 Amines blocks APIs & Intermediate Pyrimidine pharmacetical