Antitumor agent-114
- CAS No.
- 2757762-91-5
- Chemical Name:
- Antitumor agent-114
- Synonyms
- Antitumor agent-114
- CBNumber:
- CB614247956
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Antitumor agent-114 Chemical Properties, Uses, Production
Uses
Antitumor agent-114 is a potent stimulator of interferon genes (STING) agonist. Antitumor agent-114 activates immunity and reduces tumor volume in a mouse model of breast cancer. Antitumor agent-114 can be used for immunity and cancer diseases research[1].
in vivo
Antitumor agent-114 (compound 14c) (2, 0.67, 0.22 mg/kg for intratumoral on day 1, 4, and 7) modulates tumor eradication by systemic immune activation in 4T1 tumor-bearing mice model[1].
| Animal Model: | 4T1 tumor-bearing mice model[1] |
| Dosage: | 2, 0.67, 0.22 mg/kg |
| Administration: | Intratumoral (i.t.) |
| Result: | Reached 80 and 70% tumor growth inhibition (TGI) in the groups treated with 2 and 0.67 mg/kg. Induced tumor regression in 7 of 8 mice at a dose of 2 mg/kg. |
References
[1] Dejmek M, et al. Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy. Eur J Med Chem. 2023 Nov 5;259:115685. DOI:10.1016/j.ejmech.2023.115685
Antitumor agent-114 Preparation Products And Raw materials
Raw materials
Preparation Products
Antitumor agent-114 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from Antitumor agent-114 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Antitumor agent-114
2757762-91-5
|
10g | TargetMol Chemicals Inc. |
-
- Antitumor agent-114
2757762-91-5
- TargetMol Chemicals Inc.
