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Eg5-IN-2

Eg5-IN-2 structure

CAS No.: 1629735-05-2

Chemical Name:: Eg5-IN-2

Synonyms: Eg5-IN-2;1H-Imidazole-2-butanamide, 4-(2,5-difluorophenyl)-γ-[[[(3S,4R)-4-fluoro-3-pyrrolidinyl]methyl][(2S)-2-hydroxy-1-oxopropyl]amino]-N,β,β-trimethyl-1-(phenylmethyl)-, (γR)-

CBNumber:: CB614255708

Molecular Formula:: C31H38F3N5O3

Molecular Weight:: 585.66

MDL Number:

MOL File:: 1629735-05-2.mol

MSDS File:: SDS

Last updated:2025-05-30 08:03:24

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Eg5-IN-2 Properties

Boiling point	770.869±60.00 °C(Press: 760.00 Torr)(predicted)
Density	1.288±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	13.519±0.20(predicted)

Eg5-IN-2 Chemical Properties, Uses, Production

Uses

Eg5-IN-2 (Compound Scaffold B (4)) is an Eg5 inhibitor (IC50: < 0.5 nM). Eg5-IN-2 can be used as an ADC payload for synthesis of ADCs[1].

References

[1] Karpov AS, et al. Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization. ACS Med Chem Lett. 2019 Dec 3;10(12):1674-1679. DOI:10.1021/acsmedchemlett.9b00468

Eg5-IN-2 Preparation Products And Raw materials

Raw materials

Preparation Products

Eg5-IN-2 Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

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Eg5-IN-2 1H-Imidazole-2-butanamide, 4-(2,5-difluorophenyl)-γ-[[[(3S,4R)-4-fluoro-3-pyrrolidinyl]methyl][(2S)-2-hydroxy-1-oxopropyl]amino]-N,β,β-trimethyl-1-(phenylmethyl)-, (γR)- 1629735-05-2