SESELIN
- CAS No.
- 523-59-1
- Chemical Name:
- SESELIN
- Synonyms
- Sesalin;Xie Hao Su;Seselin, 10 mM in DMSO;8,8-dimethylpyrano[2,3-h]chromen-2-one;8,8-dimethylpyrano[2,3-f]chromen-2-one;2,2-Dimethyl-1,5-dioxaphenanthrene-6(2H)-one;8,8-Dimethyl-2H,8H-pyrano[2,3-f]chromen-2-one;8,8-Dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one;2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 8,8-dimethyl-
- CBNumber:
- CB61444407
- Molecular Formula:
- C14H12O3
- Molecular Weight:
- 228.24
- MDL Number:
- MFCD01018179
- MOL File:
- 523-59-1.mol
- MSDS File:
- SDS
| Melting point | 119-124 °C |
|---|---|
| Boiling point | 403.0±45.0 °C(Predicted) |
| Density | 1.351 g/cm3(Temp: 18 °C) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | A solid |
| color | White to off-white |
| InChI | 1S/C14H12O3/c1-14(2)8-7-10-11(17-14)5-3-9-4-6-12(15)16-13(9)10/h3-8H,1-2H3 |
| InChIKey | QUVCQYQEIOLHFZ-UHFFFAOYSA-N |
| SMILES | [o]1c2c(ccc3c2C=CC(O3)(C)C)cc[c]1=O |
| FDA UNII | 5634E8957P |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SESELIN price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29930 | Seselin ≥95% | 523-59-1 | 1mg | $169 | 2026-04-30 | Buy |
| Cayman Chemical | 29930 | Seselin ≥95% | 523-59-1 | 5mg | $502 | 2026-04-30 | Buy |
| TRC | TRC-S280650-5MG | Seselin | 523-59-1 | 5mg | $447 | 2026-06-03 | Buy |
| Biosynth | FD159177 | Seselin | 523-59-1 | 10mg | $150 | 2026-06-04 | Buy |
| Biosynth | FD159177 | Seselin | 523-59-1 | 5mg | $150 | 2026-06-04 | Buy |
SESELIN Chemical Properties,Uses,Production
Uses
Seselin is a coumarin compound that can be isolated from the root bark of the Citropsis articulata plant. Studies show that Seselin might exhibit potential antimalarial activity and that its derivatives may exhibit antithrombotic activity.
Definition
ChEBI: A natural product found in Citropsis articulata.
Biological Activity
Seselin is an anti-inflammatory, anti-parasitic and antifungal pyrancoumarin found in anise and other plants. It appears th at seselin targets Jak2 to block the proinflammatory phenotype of macrophages in models of sepsis. Seselin down-regulates levels of proinflammatory factors and activity of STAT1 and p65 in models of sepsis.
in vivo
Seselin (0.5-40.5 mg/kg; s.c.; once) shows peripheral anti-inflammatory and antinociceptive activities in mice[2].
Seselin (3-30 mg/kg; i.g.; once) ameliorates sepsis induced by caecal ligation and puncture in mice[3].
| Animal Model: | Male Swiss mice[2] |
| Dosage: | 0.5, 4.5 or 40.5 mg/kg |
| Administration: | Subcutaneous injection; once |
| Result: | Inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4% at dose of 0.5, 4.5 or 40.5 mg/kg, respectively. Elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively. |
| Animal Model: | C57BL/6 mice, caecal ligation and puncture (CLP) induced sepsis model[3] |
| Dosage: | 3, 10 and 30 mg/kg |
| Administration: | Intragastric administration, once |
| Result: | Ameliorated lung injury and decreased JAK2 phosphorylation level in lung tissue during sepsis. Reduced the immune cell counts in BALF induced by CLP. |
SESELIN Preparation Products And Raw materials
Raw materials
Preparation Products
SESELIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| Shanghai Yihe Biological Technology Co., Ltd. | 021-68882955 17721395025 | 2423903095@qq.com | China | 4999 | 58 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 8379 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Nanjing Digger Medical Technology Co. Ltd. | 025-025-51191215 18013836722 | 2399235533@qq.com | China | 4932 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2934 | 58 |
