VU0448088 (ML253)
- CAS No.
- 1417616-42-2
- Chemical Name:
- VU0448088 (ML253)
- Synonyms
- VU0448088;VU0448088 (ML253);Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-5-chloro-4,6-dimethyl-N-(4-pyridinylmethyl)-
- CBNumber:
- CB614482502
- Molecular Formula:
- C16H15ClN4OS
- Molecular Weight:
- 346.84
- MDL Number:
- MOL File:
- 1417616-42-2.mol
- MSDS File:
- SDS
VU0448088 (ML253) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1136937 | VU0448088 98.67% | 1417616-42-2 | 5mg | $119 | 2026-06-04 | Buy |
| ChemScene | CS-1136937 | VU0448088 98.67% | 1417616-42-2 | 10mg | $190 | 2026-06-04 | Buy |
| ChemScene | CS-1136937 | VU0448088 98.67% | 1417616-42-2 | 25mg | $357 | 2026-06-04 | Buy |
| ChemScene | CS-1136937 | VU0448088 98.67% | 1417616-42-2 | 50mg | $574 | 2026-06-04 | Buy |
| ChemScene | CS-1136937 | VU0448088 98.67% | 1417616-42-2 | 100mg | $921 | 2026-06-04 | Buy |
VU0448088 (ML253) Chemical Properties, Uses, Production
Uses
VU0448088 (ML253) is a potent and cross the blood-brain barrier tricyclic muscarinic acetylcholine receptor subtype 4 (M4) positive allosteric modulator with EC50 values of 56, 176 nM for human and rat, respectively. VU0448088 has the potential for the research of psychotic[1][2].
in vivo
VU0448088 (3, 10, 30, 56.6, 100 mg/kg; i.p.) reverses amphetamine-induced hyperlocomotion in a dose-dependent manner [1].
| Animal Model: | Rat (amphetamine-induced hyperlocomotion)[1] |
| Dosage: | 3, 10, 30, 56.6, 100 mg/kg |
| Administration: | IP |
| Result: | Reversed amphetamine-induced hyperlocomotion in a dose-dependent manner, showed a modest reduction of 26% at a dose of 10 mg/kg; at the three highest doses (30, 56.6 and 100 mg/kg), showed significant reductions of 47.9%, 53.7% and 57.3%, respectively. |
IC 50
mAChR4: 56 nM (EC50)
References
[1] Le U, et al. Discovery of a selective M positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia. Bioorg Med Chem Lett. 2013 Jan 1;23(1):346-50. DOI:10.1016/j.bmcl.2012.10.073
VU0448088 (ML253) Preparation Products And Raw materials
Raw materials
Preparation Products
VU0448088 (ML253) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 15000803246 18149758185 | sales-cpd@caerulumpharma.com | China | 478 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
