Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Xanomeline

Xanomeline

Xanomeline Structure
Xanomeline structure
CAS No.
131986-45-3
Chemical Name:
Xanomeline
Synonyms
XANOMELINE;3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole;Memcor;Lomeron;LY-246708;NNC-11-0232;3-(Hexyloxy);Xanomeline(LY-246708);JNJ-7777120 (Zanoterone);Xanomeline, 10 mM in DMSO
CBNumber:
CB4144966
Molecular Formula:
C14H23N3OS
Molecular Weight:
281.42
MDL Number:
MFCD00867179
MOL File:
131986-45-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:03:10
Request For Quotation

Xanomeline Properties

Boiling point 397.0±42.0 °C(Predicted)
Density 1.101±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility H2O: soluble10mg/mL, clear (warmed)
form powder
pka 7.34±0.40(Predicted)
color off-white
InChI InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3
InChIKey JOLJIIDDOBNFHW-UHFFFAOYSA-N
SMILES C1N(C)CCC=C1C1C(OCCCCCC)=NSN=1
FDA UNII 9ORI6L73CJ

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P312-P330
WGK Germany  3

Xanomeline price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich X2754 Xanomeline L-tartrate hydrate ≥98% (HPLC) 131986-45-3 25mg $905 2022-05-15 Buy
TRC TRC-H298183-50MG 3-(Hexyloxy)-4-(1-Methyl-1,2,5,6-Tetrahydropyridin-3-Yl)-1,2,5-Thiadiazole 131986-45-3 50mg $154 2026-06-03 Buy
TRC TRC-H298183-10MG 3-(Hexyloxy)-4-(1-Methyl-1,2,5,6-Tetrahydropyridin-3-Yl)-1,2,5-Thiadiazole 131986-45-3 10mg $97 2026-06-03 Buy
TRC TRC-H298183-100MG 3-(Hexyloxy)-4-(1-Methyl-1,2,5,6-Tetrahydropyridin-3-Yl)-1,2,5-Thiadiazole 131986-45-3 100mg $256 2026-06-03 Buy
Biosynth FX65209 Xanomeline oxalate 131986-45-3 10mg $178.5 2026-06-04 Buy
Product number Packaging Price Buy
X2754 25mg $905 Buy
TRC-H298183-50MG 50mg $154 Buy
TRC-H298183-10MG 10mg $97 Buy
TRC-H298183-100MG 100mg $256 Buy
FX65209 10mg $178.5 Buy

Xanomeline Chemical Properties, Uses, Production

Description

Xanomeline is used as a potent and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist to increase neuronal excitability. Xanomeline is used in studies of neurological disorders such as Alzheimer's disease and schizophrenia. However, development of the drug was halted due to severe cholinergic adverse effects. Currently, xanomeline-trospium (KarXT) (a peripheral cholinergic antagonist) has been explored for the treatment of schizophrenia and a New Drug Application has been filed with the FDA, with a decision on whether it will be approved or not expected on 26 September 2024.

Chemical Properties

Xanomeline Oxalate: C14H23N3OSC2H2O4. [141064-23-5]. Crystallized from acetone, melting point 148°C.
(+)-L-Tartrate: C14H23N3OSC4H6O6. [152854-19-8]. Crystallized from 2-propanol, melting point 95.5°C.

Uses

Alzheimer’s disease treatment (cholinergic agonist).

Definition

ChEBI: Xanomeline is a member of thiadiazoles and a tetrahydropyridine. It has a role as a muscarinic agonist and a serotonergic agonist.

Mechanism of action

Xanomeline's mechanism of action is is to rebalance key neurotransmitter circuits, including acetylcholine, dopamine and glutamate, which are disrupted in schizophrenia and related disorders.

in vivo

Xanomeline (0.5~3 mg/kg; s.c.; 1~3 hours) induces salivation and vomiting in some monkeys[3].
Xanomeline shows functional dopamine antagonism and an antipsychotic-like profile. Xanomeline inhibits D-amphetamine- and ( )-apomorphine-induced behavior and do not cause extrapyramidal side effects[3].

Animal Model:Male Cebus apella monkeys
Dosage:0.5~3 mg/kg
Administration:S.c.; 1~3 hours
Result:Induced salivation and vomiting in some monkeys.

IC 50

mAChR1; mAChR4

Xanomeline synthesis

131988-19-7
131986-45-3
Synthesis of Xanomeline from 3-(4-Hexyloxy-1,2,5-thiadiazol-3-yl)-1-methylpyridinium iodide

Xanomeline Preparation Products And Raw materials

Raw materials

3-Pyridylacetonitrile Sodium borohydride Sodium hexylate Iodomethane Praseodymium(III) nitrate hexahydrate
Formamide

1of2

Preparation Products

Xanomeline Suppliers

Global Suppliers ( 141)
Supplier Tel Email Country ProdList Advantage
FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd 25-8690-7345 18651693585 zfx@farmasino.com China 136 58
Shanghai Jidu Biotechnology Co., Ltd. 13851761812 13851761812@163.com China 497 58
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2110 70
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Shanghai Famo Bio-chemical Technology Company Ltd. 02136680027 15800370750 1706640024@qq.com China 498 56
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9330 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. 027-65388397 18164111589 3321478047@qq.com China 2002 55
Shanghai Haozhixiang Biotechnology Co., Ltd 526763801 13301653310 526763801@qq.com China 7989 55
Supplier Advantage
FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd 58
Shanghai Jidu Biotechnology Co., Ltd. 58
LGM Pharma 70
NCE Biomedical Co.,Ltd. 55
Shanghai Famo Bio-chemical Technology Company Ltd. 56
Quality Control Solutions Ltd. 56
Finetech Industry Limited 58
LETOPHARM LIMITED 58
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. 55
Shanghai Haozhixiang Biotechnology Co., Ltd 55

View Latest Price from Xanomeline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE USP/EP/BP pictures 2026-08-20 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE USP/EP/BP
131986-45-3
 $1.10 1g 99.9% 100 Tons Min Dideu Industries Group Limited
Xanomeline pictures 2026-06-30 Xanomeline
131986-45-3
 1KG 98% 5000KGS Shaanxi Dideu New Materials Co. Ltd
Xanomeline pictures 2026-05-25 Xanomeline
131986-45-3
 $48.00-163.00 98.44% 10g TargetMol Chemicals Inc.
  • Xanomeline pictures
  • Xanomeline
    131986-45-3
  • $0.00
  • 98%
  • Shaanxi Dideu New Materials Co. Ltd
  • Xanomeline pictures
  • Xanomeline
    131986-45-3
  • $48.00-163.00
  • 98.44%
  • TargetMol Chemicals Inc.

Xanomeline Spectrum

Xanomeline(131986-45-3)1HNMR

131986-45-3 (Xanomeline) Related Search:

(-)-Huperzine A Donepezil SABCOMELINE 1,2,5-Thiadiazol-3-ol Xanomeline
Xanomeline metabolite A 3-(hexyloxy)-4-(pyridin-3-yl)-1,2,5-thiadiazole Pyridinium, 5-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-3-hydroxy-1-methyl- Pyridine, 3-[4-(heptyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl- Xanomeline Metabolite B
3-Pyridineacetonitrile, α-hydroxy- bis(4-(pyridin-3-yl)-1,2,5-thiadiazol-3-yl)sulfane 3-(4-Hexyloxy-1,2,5-thiadiazol-3-yl)-1-methylpyridinium iodide Pyridine, 3-(1,2,5-thiadiazol-3-yl)- Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-, 1-oxide
Xanomeline Metabolite B Sodium Salt Xanomeline Metabolite B-d3 Sodium Salt Xanomeline-d11

1of4

3-[4-(Hexy loxy)-1，2，5-thiadiazol-3-y1]-1，2，5，6-tetrahydro-1-methylpyridine 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE XANOMELINE Lomeron LY-246708 Memcor NNC-11-0232 Xanomeline L-tartrate hydrate 3-(Hexyloxy) -4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl) 3-Hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl- Xanomeline L-tartrate hydrate >=98% (HPLC) 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE USP/EP/BP Xanomeline(LY-246708) 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-1,2,5-thiadiazole Xanomeline, 10 mM in DMSO JNJ-7777120 (Zanoterone) 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole 131986-45-3 C14H23N3OS API