2,2-Dimethylthiopropionamide
- CAS No.
- 630-22-8
- Chemical Name:
- 2,2-Dimethylthiopropionamide
- Synonyms
- NSC 381432;Thiopivalamide;Neopentanethioamide;Dalafenil Impurity 4;Dabrafenib Impurity 24;2,2-DIMETHYLTHIOPROPIOMIDE;2,2-Trimethylthioacetamide;2,2-DIMETHYLTHIOPROPIONAMIDE;2,2,2-Trimethylthioacetamide,;2,2,2-Dimethylthiopropionamide
- CBNumber:
- CB61449866
- Molecular Formula:
- C5H11NS
- Molecular Weight:
- 117.21
- MDL Number:
- MFCD09742834
- MOL File:
- 630-22-8.mol
- MSDS File:
- SDS
| Melting point | 117-119℃ (ethyl acetate hexane ) |
|---|---|
| Boiling point | 162.1±23.0℃ (760 Torr) |
| Density | 0.978±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 51.9±22.6℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Ethyl Acetate |
| form | Solid |
| pka | 13.33±0.29(Predicted) |
| color | White |
| Water Solubility | Soluble in water (10 g/L) (25°C). |
| InChI | InChI=1S/C5H11NS/c1-5(2,3)4(6)7/h1-3H3,(H2,6,7) |
| InChIKey | FJZJUSOFGBXHCV-UHFFFAOYSA-N |
| SMILES | C(N)(=S)C(C)(C)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312a-P330-P501a | |||||||||
| HS Code | 2930909899 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2,2-Dimethylthiopropionamide price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 273405 | 2,2-Dimethylthiopropionamide Asreported | 630-22-8 | 1g | $422 | 2026-06-03 | Buy |
| Usbiological | 273405 | 2,2-Dimethylthiopropionamide Asreported | 630-22-8 | 5g | $775 | 2026-06-03 | Buy |
| Usbiological | 273405 | 2,2-Dimethylthiopropionamide Asreported | 630-22-8 | 10g | $1105 | 2026-06-03 | Buy |
| Usbiological | 273405 | 2,2-Dimethylthiopropionamide Asreported | 630-22-8 | 25g | $1836 | 2026-06-03 | Buy |
| Usbiological | 273405 | 2,2-Dimethylthiopropionamide Asreported | 630-22-8 | 50g | $2598 | 2026-06-03 | Buy |
2,2-Dimethylthiopropionamide Chemical Properties, Uses, Production
Uses
2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
Synthesis
To a round bottom flask (250 mL) was added trimethyl amine (5.0 g, 0.049 mol) and Lawesson's reagent (8.0g, 0.020 mol), dissolved in THF (100 mL), nitrogen, 80° C oil. The reaction bath for 4 hours. TLC monitors the reaction progress. After completion of the reaction, the solvent was removed by rotary evaporation; the residue was purified by silica gel column chromatography (petroleum ether: 1: ethyl acetate = 10) to give a white solid 2,2-Dimethylthiopropionamide (3.7 g, 65percent yield).
References
[1] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9655 - 9662
[2] Phosphorus and Sulfur and the Related Elements, 1986, vol. 26, p. 169 - 184
[3] Patent: CN103936728, 2016, B. Location in patent: Paragraph 0211; 0213; 0214; 0215
[4] Canadian Journal of Chemistry, 1977, vol. 55, p. 2331 - 2335
[5] Journal of the Chemical Society [Section] C: Organic, 1966, p. 686 - 691
2,2-Dimethylthiopropionamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beihua Chemical (Shandong) Co., LTD | 0531-68653689 13127106931 | 1720760574@qq.com | China | 120 | 58 |
| Shandong Winner Biotechnology Co., Ltd. | 15315319889 15315319889 | wannaswsw@163.com | China | 400 | 58 |
| Enki Biopharmaceuticals(Shanghai) Limited | +86-21 5768 0965 +86-13916707528 | yusu@enkibiopharma.com | China | 47 | 55 |
| Jiangsu laurel Pharma Co., Ltd | 15861782979 | 32860091@qq.com | China | 67 | 58 |
| Lianyungang Xuanyuan Chemical Co., Ltd | 0518-85415818; 18000194506 | 2818153737@qq.com | China | 48 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 6206333 13167063860 | anhua.mao@aladdin-e.com | China | 49497 | 58 |
| JINAN RUIFENG PHARMACEUTICAL TECHNOLOGY CO.,LTD | 18668921571 | liujnlz@126.com | China | 22 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9409 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
View Latest Price from 2,2-Dimethylthiopropionamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-14 | 2,2-Dimethylthiopropionamide
630-22-8
|
1kg | 98%min | 10mt | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-10-12 | 2,2-Dimethylpropanethioamide
630-22-8
|
1kg | 99.0% | 20000 | Enki Biopharmaceuticals (Shanghai) Limited | ||
 |
2026-09-23 | 2,2-Dimethylthiopropionamide
630-22-8
|
99.9% | 40-80kgs | Zison Pharmaceutical (Shandong) Co., Ltd. |
-
- 2,2-Dimethylthiopropionamide
630-22-8
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2,2-Dimethylpropanethioamide
630-22-8
- 99.0%
- Enki Biopharmaceuticals (Shanghai) Limited
-
- 2,2-Dimethylthiopropionamide
630-22-8
- $0.00
- 99.9%
- Zison Pharmaceutical (Shandong) Co., Ltd.
