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Sulbenicillin sodium

Sulbenicillin sodium Structure
Sulbenicillin sodium structure
CAS No.
28002-18-8
Chemical Name:
Sulbenicillin sodium
Synonyms
sulpelin;kedacillin;lilacillin;sulfocillin;a-Sulfocillin;SULBENICILLIN SODIUM;disodiumsulbenicillin;sulbenicillindisodium;sulfobenzylpenicillin;Sulfonpicillin sodium
CBNumber:
CB6145730
Molecular Formula:
C16H16N2Na2O7S2
Molecular Weight:
458.42
MDL Number:
MFCD01682086
MOL File:
28002-18-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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Sulbenicillin sodium Properties

storage temp. Inert atmosphere,Room Temperature
form Solid
color White to off-white
Water Solubility Water: 250 mg/mL (545.35 mM)
InChIKey FWRNIJIOFYDBES-OVLVVYMKNA-L
SMILES N12C([C@@H](NC(=O)C(S(=O)(=O)[O-])C3C=CC=CC=3)[C@H]1SC(C)(C)[C@@H]2C(=O)[O-])=O.[Na+].[Na+] |&1:2,17,22,r|
CAS DataBase Reference 28002-18-8(CAS DataBase Reference)
FDA UNII 29SO9LIM1Q
UNSPSC Code 51101500
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Resp. Sens. 1
Skin Sens. 1

Sulbenicillin sodium price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FS40951 Sulbenicillin sodium 28002-18-8 2g $207.98 2026-06-04 Buy
Biosynth FS40951 Sulbenicillin sodium 28002-18-8 5g $332.75 2026-06-04 Buy
Biosynth FS40951 Sulbenicillin sodium 28002-18-8 10g $582.4 2026-06-04 Buy
Biosynth FS40951 Sulbenicillin sodium 28002-18-8 25g $832 2026-06-04 Buy
Biosynth FS40951 Sulbenicillin sodium 28002-18-8 50g $1331.5 2026-06-04 Buy
Product number Packaging Price Buy
FS40951 2g $207.98 Buy
FS40951 5g $332.75 Buy
FS40951 10g $582.4 Buy
FS40951 25g $832 Buy
FS40951 50g $1331.5 Buy

Sulbenicillin sodium Chemical Properties,Uses,Production

Originator

Lillacillin,Takeda,Japan,1973

Uses

Sulbenicillin Sodium is an antibiotic which belongs to a group of compounds known as penicillin antibiotics. Sulbenicillin Sodium is a combination of sulbactam and ampicillin. Sulbactam is a beta-lactamase inhibitor that works by binding to bacterial beta-lactamase enzymes, which are produced by some Gram-negative and Gram-positive bacteria to inactivate beta-lactam antibiotics including penicillins. By inhibiting the activity of beta-lactamase enzymes, sulbactam restores the activity of ampicillin against susceptible bacteria, thereby enhancing the spectrum and potency of the antibiotic.

Definition

ChEBI: Sulbenicillin disodium is an organic sodium salt. It contains a sulbenicillin(2-).

Manufacturing Process

To a suspension of 1.08 parts by weight of 6-aminopenicillanic acid in 8 parts by volume of water is added 1.48 parts by weight of sodium bicarbonate. After the mixture is dissolved, a solution of 1.18 parts by weight of α-sulfophenylacetyl chloride in 10 parts by volume of diethylether is gradually added thereto. The mixture is stirred at a temperature in the neighborhood of 0°C for 1 hour. The aqueous layer is washed twice with 10 parts by volume of portions of ether and adjusted to pH 1.2 with cation exchange resin of polystyrene sulfonic acid type under constant cooling. Then the solution is washed twice with 15 parts by volume of portions of ethyl acetate, followed by extraction twice with 15 parts by volume of portions of n-butanol. The extracts are combined and washed twice with 15 parts by volume of portions of water and, then, extracted with an aqueous solution of sodium bicarbonate. The extract is adjusted to pH 6.5, washed with ether and lyophilized to give the sodium salt of α-sulfobenzylpenicillin. Yield is 1.2 parts by weight.

Therapeutic Function

Antibacterial

Biological Activity

Sulbenicillin Sodium inhibits bacterial cell wall synthesis and the inhibition of beta-lactamase enzymes th at would otherwise inactivate the penicillin antibiotic.

References

[1] Patent: CN108373475, 2018, A. Location in patent: Paragraph 0058; 0065; 0073
[2] Patent: CN107641130, 2018, A. Location in patent: Paragraph 0059; 0060; 0065; 0072; 0077

Sulbenicillin sodium Preparation Products And Raw materials

Raw materials

6-Aminopenicillanic acid 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenyl-2-sulfoacetyl)amino]-, (2S,5R,6R)- α-Sulfophenylacetyl chloride alpha-Sulfophenylacetic acid Acetone
Sodium 2-ethylhexanoate

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Preparation Products

Sulbenicillin sodium Suppliers

Global( 188)Suppliers
Supplier Tel Email Country ProdList Advantage
Chongqing Fuan Pharmaceutical Co., Ltd -- sales@fapharm.com China 164 38
Wuhan Fortuna Chemical Co., Ltd 027-59207852 13308628970 buy@fortunachem.com China 2698 58
ShangHai YuanYe Biotechnology Co., Ltd. 15026964105 shyysw007@163.com China 4998 60
AILY INTL CHEMICAL CORP LTD 025-83208295 18913388297 ben@ailychem.com China 132 50
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
Nanjing Sunlida Biological Technology Co., Ltd. 025-57798810 18652991625 sales@sunlidabio.com China 3223 55
TargetMol Chemicals Inc. 021-021-33632979 15002134094 marketing@targetmol.com China 7993 58
Hubei Jusheng Technology Co.,Ltd 027-59599241 18871490274 1400878000@qq.com China 9506 58
Shanghai QianYan Bio-technology Co., Ltd 02781293128 orders@biochemsafebuy.com China 9904 55
Raw material medicin reagent co.,Ltd sales@njromanme.com China 4511 58
Supplier Advantage
Chongqing Fuan Pharmaceutical Co., Ltd 38
Wuhan Fortuna Chemical Co., Ltd 58
ShangHai YuanYe Biotechnology Co., Ltd. 60
AILY INTL CHEMICAL CORP LTD 50
Beijing HuaMeiHuLiBiological Chemical 58
Nanjing Sunlida Biological Technology Co., Ltd. 55
TargetMol Chemicals Inc. 58
Hubei Jusheng Technology Co.,Ltd 58
Shanghai QianYan Bio-technology Co., Ltd 55
Raw material medicin reagent co.,Ltd 58

View Lastest Price from Sulbenicillin sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sulbenicillin disodium pictures 2026-07-15 Sulbenicillin disodium
28002-18-8
 $50.00 99.35% 10g TargetMol Chemicals Inc.
Sulbenicillin sodium pictures 2021-11-27 Sulbenicillin sodium
28002-18-8
 $120.00 100g 99.99% 5ton/Month Qiuxian Baitai New Material Co., LTD
Sulbenicillin sodium pictures 2021-07-13 Sulbenicillin sodium
28002-18-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

28002-18-8(Sulbenicillin sodium)Related Search:

CARBENICILLIN Penicillin G Sodium carbonate Sodium gluconate Penicillin G sodium salt
Ethylenediaminetetraacetic acid disodium salt Dimethyl phthalate Dimethyl ether Bensulfuron methyl Dimethyl fumarate
Dimethyl sulfide Carbenicillin disodium Sodium hydroxide Sodium formate Sodium chloride
Poly(dimethylsiloxane) N,N-Dimethylacetamide Sodium bicarbonate

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alpha-sulfobenzylpenicillindisodium sulpelin SULBENICILLIN DISODIUM SALT SULBENICILLIN SODIUM disodium (2s,5r,6r)-3,3-dimethyl-7-oxo-6-[(r)-2-phenyl-2-sulfonatoacetamido]-4-thia-azabicyclo[3.2.0]heptane-2-carboxylate disodium [2S-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylsulphonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenyl-2-sulfoacetamido)-, disodium salt (8CI) 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylsulfoacetyl)amino]-, disodium salt, (2S,5R,6R)- (9CI) 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylsulfoacetyl)amino]-, disodium salt, [2S-(2a,5a,6b)]- a-Sulfobenzylpenicillin disodium salt a-Sulfobenzylpenicillin sodium salt a-Sulfocillin (2S,5β)-3,3-Dimethyl-7-oxo-6α-[(R)-2-phenyl-2-sulfoacetylamino]-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid disodium salt 6α-[(R)-Phenyl(sodiooxysulfonyl)acetylamino]penicillanic acid sodium salt Sulbenicillin sodiuM Sterile disodiumalpha-sulfobenzylpenicillin disodiumsulbenicillin disodiumsulfobenzylpenicillin kedacillin lilacillin sulbenicillindisodium sulfobenzylpenicillin sulfocillin Sulbenicillin (Kedacillin, Sulfocillin) (2S,5R,6R)-3,3-dimethyl-6-(2-phenyl-2-sulfoacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt Ticarcillin Sodium and Potassium Clavulanate Sulbenicillin Disodium Salt (Mixture of Diastereomers) Sulbenicillin sodium USP/EP/BP Sodium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenyl-2-sulfonatoacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Sulfonpicillin sodium Sulfobenzillin sodium 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylsulfoacetyl)amino]-, disodium salt,(2S,5R,6R)- Sulbenicillin disodium, 10 mM in DMSO 28002-18-8 C17H19N2Na2O7S C16H16N2NaO7S2 C16H16N2Na2O7S2 antibiotic API 28002-18-8