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Coronarin A

Coronarin A Structure
Coronarin A structure
CAS No.
119188-33-9
Chemical Name:
Coronarin A
Synonyms
Coronarin A;(2S,4R,4aS,8aS)-4-[(E)-2-(3-Furyl)vinyl]-4a,8,8-trimethyl-3-methylenedecahydro-2-naphthalenol;2-Naphthalenol, 4-[(1E)-2-(3-furanyl)ethenyl]decahydro-4a,8,8-trimethyl-3-methylene-, (2S,4R,4aS,8aS)-
CBNumber:
CB61469842
Molecular Formula:
C20H28O2
Molecular Weight:
300.44
MDL Number:
MFCD17214879
MOL File:
119188-33-9.mol
MSDS File:
SDS
Last updated:2026-07-28 08:09:04
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Coronarin A Properties

Melting point 100-102 °C(Solvent: Hexane)
Boiling point 401.122±40.00 °C(Press: 760.00 Torr)(predicted)
Density 1.053±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 14.632±0.70(predicted)
form Solid
color White to off-white

Coronarin A price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 379905 Coronarin A ≥98% 119188-33-9 5mg $871 2026-06-03 Buy
Biosynth UEA18833 Coronarin A 119188-33-9 5mg $880.55 2026-06-05 Buy
Biosynth UEA18833 Coronarin A 119188-33-9 10mg $1408.8 2026-06-05 Buy
Biosynth UEA18833 Coronarin A 119188-33-9 25mg $2297.25 2026-06-05 Buy
Biosynth UEA18833 Coronarin A 119188-33-9 50mg $3675 2026-06-05 Buy
Product number Packaging Price Buy
379905 5mg $871 Buy
UEA18833 5mg $880.55 Buy
UEA18833 10mg $1408.8 Buy
UEA18833 25mg $2297.25 Buy
UEA18833 50mg $3675 Buy

Coronarin A Chemical Properties, Uses, Production

Uses

Coronarin A is an orally active natural compound that inhibits mTORC1 and S6K1 to increase IRS1 activity. Coronarin A shows anti-inflammatory activity and can also be used for type 2 diabetes mellitus research[1].

in vivo

Coronarin A (30 or 100 mg/kg; i.p. or p.o.; once daily for 22 days) ameliorates hyperglycemia in mice[1].
Coronarin A (100 mg/kg; p.o.; once daily for 22 days) inhibits the mTOR/S6K1 pathway to activate PI3K/Akt and ERK/β-catenin signaling in livers of ob/ob mice[1].
Pharmacokinetic properties of Coronarin A after single administrationa in ob/ob mice[1].

Coronarin At1/2 (h)tmax (h)Cmax (ng/mL)AUC0-t (ng·h/mL)AUC0-∞ (ng·h/mL)MRT (h)
i.p.14.81.0107345711104521.7
p.o.3.011.0388169418564.88

Data are presented as the mean of three mice.
aCoronarin A was intraperitoneally or orally administered at 30 mg/kg to ob/ob mice.
Animal Model:Male ob/ob mice[1]
Dosage:30 mg/kg (IP) or 100 mg/kg (PO)
Administration:Oral or intraperitoneal administration, once daily for 22 days
Result:Significantly decreased the non-fasting and fasting blood glucose. Significantly reduced the serum insulin concentration at 15 min after glucose loading, reduced the average daily food intake while the body weight was unaffected. Increased hepatic glycogen content and the expression levels of gluconeogenic gene Pck1 and G6pc were significantly decreased.
Animal Model:Female ob/ob mice[1]
Dosage:30 mg/kg
Administration:Intraperitoneal or oral administration (Pharmacokinetic Analysis)
Result:Intraperitoneal injection exhibited higher plasma exposure than oral gavage at the same dose of 30 mg/kg, with Cmax value of 1073 and 388 ng/mL, respectively.

IC 50

mTORC1; S6K1

References

[1] Huang SL, et al. Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice. Acta Pharmacol Sin. 2022 Sep 9. DOI:10.1038/s41401-022-00985-5

Coronarin A Preparation Products And Raw materials

Raw materials

Preparation Products

Coronarin A Suppliers

Global Suppliers ( 47)
Supplier Tel Email Country ProdList Advantage
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
BioBioPha Co., Ltd. 0871-65217109 y.liu@mail.biobiopha.com China 5641 65
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Shanghai Yongye Biotechnology Co., Ltd. 86-021-61559134 15921386130 3423497944@qq.com China 8135 55
ALB Technology Limited 702-983-3769 sales@albtechnology.com United States 2992 55
Wuhan ChemFaces Biochemical Co., Ltd. 18607101326 15172504745 aileen@chemfaces.com China 6904 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89664 60
Shanghai ChengShao Biological Technology Co., Ltd. 021-61847300 13341622919 shcss01@163.com China 4806 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Supplier Advantage
Chembest Research Laboratories Limited 61
BioBioPha Co., Ltd. 65
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Shanghai Yongye Biotechnology Co., Ltd. 55
ALB Technology Limited 55
Wuhan ChemFaces Biochemical Co., Ltd. 55
EMMX Biotechnology LLC 60
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai ChengShao Biological Technology Co., Ltd. 58
BOC Sciences 58

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Coronarin A 2-Naphthalenol, 4-[(1E)-2-(3-furanyl)ethenyl]decahydro-4a,8,8-trimethyl-3-methylene-, (2S,4R,4aS,8aS)- (2S,4R,4aS,8aS)-4-[(E)-2-(3-Furyl)vinyl]-4a,8,8-trimethyl-3-methylenedecahydro-2-naphthalenol 119188-33-9