3-Bromo-5-nitrobenzaldehyde
- CAS No.
- 355134-13-3
- Chemical Name:
- 3-Bromo-5-nitrobenzaldehyde
- Synonyms
- 3-Bromo-5-nitrobenzaldehyde;3-Nitro-5-bromo-benzaldehyde;3-Bromo-5-formylnitrobenzene;3-Fluoro-5-nitrobenzaldehyde;Benzaldehyde,3-bromo-5-nitro-;3-Bromo-5-nitrobenzaldehyde 95%;3-BroMo-5-nitrobenzaldehyde, 97+%
- CBNumber:
- CB61471016
- Molecular Formula:
- C7H4BrNO3
- Molecular Weight:
- 230.02
- MDL Number:
- MFCD00100097
- MOL File:
- 355134-13-3.mol
- MSDS File:
- SDS
| Melting point | 101-106 °C |
|---|---|
| Boiling point | 306.9±27.0 °C(Predicted) |
| Density | 1.781 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Methanol |
| form | Powder |
| color | Pale brown |
| InChI | 1S/C7H4BrNO3/c8-6-1-5(4-10)2-7(3-6)9(11)12/h1-4H |
| InChIKey | OUDCOMBHRXKPIJ-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1cc(Br)cc(C=O)c1 |
| Comptox DTXSID | DTXSID90587759 |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H317-H319-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-43 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2913000090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Bromo-5-nitrobenzaldehyde price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 702986 | 3-Bromo-5-nitrobenzaldehyde 97% | 355134-13-3 | 250mg | $69.5 | 2023-01-07 | Buy |
| Sigma-Aldrich | 702986 | 3-Bromo-5-nitrobenzaldehyde 97% | 355134-13-3 | 1g | $125 | 2023-01-07 | Buy |
| TCI Chemical | B4982 | 3-Bromo-5-nitrobenzaldehyde | 355134-13-3 | 1G | $59 | 2026-04-30 | Buy |
| TCI Chemical | B4982 | 3-Bromo-5-nitrobenzaldehyde | 355134-13-3 | 5G | $177 | 2026-04-30 | Buy |
| Apolloscientific | OR52145 | 3-Bromo-5-nitrobenzaldehyde 95% | 355134-13-3 | 1g | $21 | 2026-06-04 | Buy |
3-Bromo-5-nitrobenzaldehyde Chemical Properties, Uses, Production
Uses
3-Fluoro-5-nitrobenzaldehyde is used as a reactant in the design and synthesis of selective activators of cardiac myosin.
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 5867, 2007 DOI: 10.1021/jo070477u
Synthesis
99-61-6
355134-13-3
General procedure for the synthesis of 3-bromo-5-nitrobenzaldehyde from m-nitrobenzaldehyde: 3-nitrobenzaldehyde (1.0 g, 6.6 mmol) was dissolved in concentrated sulfuric acid (4.0 mL) at room temperature, followed by batchwise addition of N-bromosuccinimide (1.4 g, 7.9 mmol). The reaction mixture was heated to 65 °C and maintained at this temperature for 1 hour. After completion of the reaction, it was cooled to room temperature and the reaction solution was slowly poured into ice water, the solid was precipitated and collected by filtration. The crude product was dried with anhydrous sodium sulfate and purified by recrystallization through a solvent mixture of ethyl acetate/petroleum ether (1:10, v/v) to finally obtain 3-bromo-5-nitrobenzaldehyde (1.3 g, 82% yield) as white crystals. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 10.09 (s, 1H), 8.79-8.55 (m, 2H), 8.51 (s, 1H).
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 12, p. 5235 - 5244
[2] Journal of Organic Chemistry, 2007, vol. 72, # 15, p. 5867 - 5869
[3] European Journal of Medicinal Chemistry, 2016, vol. 116, p. 46 - 58
[4] Journal of the American Chemical Society, 2007, vol. 129, # 15, p. 4512 - 4513
[5] Patent: WO2009/153313, 2009, A1. Location in patent: Page/Page column 185
3-Bromo-5-nitrobenzaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44567 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9417 | 66 |
| Accela ChemBio Co.,Ltd. | 4000665055 | marketing@accelachem.com | China | 10969 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Litong Chemical Technology Co.,Ltd. | 13598610367 0373-7129549 | 2468833170@qq.com | China | 932 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
View Latest Price from 3-Bromo-5-nitrobenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 3-Bromo-5-nitrobenzaldehyde
355134-13-3
|
$2.00-5.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-04-04 | 3-BROMO-5-NITROBENZALDEHYDE
355134-13-3
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-06 | 3-BROMO-5-NITROBENZALDEHYDE
355134-13-3
|
$1.00 | 1kg | 95%-99% | 1000kg | Career Henan Chemical Co |
-
- 3-Bromo-5-nitrobenzaldehyde
355134-13-3
- $2.00-5.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 3-BROMO-5-NITROBENZALDEHYDE
355134-13-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-BROMO-5-NITROBENZALDEHYDE
355134-13-3
- $1.00
- 95%-99%
- Career Henan Chemical Co
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