7-(Trifluoromethoxy)-1H-indole
- CAS No.
- 396075-91-5
- Chemical Name:
- 7-(Trifluoromethoxy)-1H-indole
- Synonyms
- 7-(Trifluoromethoxy)-1H-indole;1H-Indole, 7-(trifluoroMethoxy)-
- CBNumber:
- CB61481998
- Molecular Formula:
- C9H6F3NO
- Molecular Weight:
- 201.15
- MDL Number:
- MFCD11109870
- MOL File:
- 396075-91-5.mol
- MSDS File:
- SDS
7-(Trifluoromethoxy)-1H-indole price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | T50954 | 7-(Trifluoromethoxy)-1H-indole 95+% | 396075-91-5 | 100mg | $130 | 2026-05-06 | Buy |
| Synthonix | T50954 | 7-(Trifluoromethoxy)-1H-indole 95+% | 396075-91-5 | 250mg | $274 | 2026-05-06 | Buy |
| Synthonix | T50954 | 7-(Trifluoromethoxy)-1H-indole 95+% | 396075-91-5 | 1g | $340 | 2026-05-06 | Buy |
| Synthonix | T50954 | 7-(Trifluoromethoxy)-1H-indole 95+% | 396075-91-5 | 5g | $1880 | 2026-05-06 | Buy |
| Synthonix | T50954 | 7-(Trifluoromethoxy)-1H-indole 95+% | 396075-91-5 | 10g | $2820 | 2026-05-06 | Buy |
7-(Trifluoromethoxy)-1H-indole Chemical Properties, Uses, Production
Synthesis
![CarbaMic acid, N-[2-(trifluoroMethoxy)-6-[2-(triMethylsilyl)ethynyl]phenyl]-, ethyl ester](/CAS/20150408/GIF/396075-92-6.gif)
396075-92-6
396075-91-5
General procedure for the synthesis of 7-(trifluoromethoxy)-1H-indole from the compound (CAS: 396075-92-6): first, D-7-trifluoromethoxy-1H-indole KOH (1.95 g, 34.8 mmol) was dissolved in tertiary butanol (55 mL), heated to 80 °C and kept for 2 h until the solution became homogeneous and clarified. Subsequently, ethyl (2-trifluoromethoxy-6-trimethylsilylethynyl-phenyl)-carbamate (5.214 g, 15.1 mmol) was added to this solution and heating was continued at 80 °C for 2 hours. After completion of the reaction, the solvent was removed by vacuum distillation. The organic layer was separated by partitioning the residue between ether (Et2O) and water. The organic layer was washed with brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated in vacuum. The crude product was purified by silica gel column chromatography using ethyl acetate/heptane (1-5%) as eluent to give the final title product 7-(trifluoromethoxy)-1H-indole (1.82 g, 60% yield) as a yellow liquid. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) δ 8.40 (br s, 1H), 7.58-7.55 (m, 1H), 7.25 (m, 1H), 7.09-7.07 (m, 2H), 6.62-6.60 (m, 1H); 19F NMR (300 MHz, CDCl3) δ -57.50 (s, 3F ) Confirmation. Elemental analysis (CHN) theoretical values: C 53.74%, H 3.01%, N 6.96%; measured values: C 53.86%, H 3.14%, N 6.97%.
References
[1] Patent: WO2011/79102, 2011, A1. Location in patent: Page/Page column 19
[2] Patent: WO2011/79103, 2011, A1. Location in patent: Page/Page column 29; 30
7-(Trifluoromethoxy)-1H-indole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6347 | 58 | |
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| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4967 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
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| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Changzhou Kechem Bio-Scientific Co., LTD. | 0519-68985668 13685222090 | sales@kechem.cn | China | 26012 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 54996 | 58 |
| Hubei Co-prosperity Medicine Technonlogy Co., Ltd | 2383948258 19172820304 | 2383948258@qq.com | China | 12983 | 58 |
