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PLpro-IN-3

PLpro-IN-3 structure

CAS No.: 3047093-72-8

Chemical Name:: PLpro-IN-3

Synonyms: PLpro-IN-3;2-Thiophenecarboxylic acid, 5-[[[5-[5-[1-(2-fluoro[1,1′-biphenyl]-4-yl)ethyl]-1,2,4-oxadiazol-3-yl]-2-methylphenyl]amino]methyl]-

CBNumber:: CB614907876

Molecular Formula:: C29H24FN3O3S

Molecular Weight:: 513.58

MDL Number:

MOL File:: 3047093-72-8.mol

Last updated:2025-04-18 09:51:18

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PLpro-IN-3 Properties

Boiling point	719.3±70.0 °C(predicted)
Density	1.321±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka	3.56±0.10(predicted)

PLpro-IN-3 Chemical Properties, Uses, Production

Uses

PLpro-IN-3 (compound 26R) is a potent Papain-like protease (PLpro) inhibitor with a IC50 of 1.0μM. PLpro-IN-3 exhibits antiviral activity against SARS-CoV-2 with a EC50 of 4.3 μM[1].

References

[1] Qin B, et al. Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole Derivatives Containing an Aryl Carboxylic Acid Moiety as Potent Sarbecovirus Papain-like Protease Inhibitors. J Med Chem. 2024 Jun 27;67(12):10211-10232. DOI:10.1021/acs.jmedchem.4c00534

PLpro-IN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

PLpro-IN-3 Suppliers

Global Suppliers ( 1)

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol	400-821-0310 15002144251	xuexiang.shao@tsbiochem.com	China	29128	58

Supplier	Advantage
TargetMol	58

3047093-72-8 (PLpro-IN-3) Related Search:

Brequinar Ritonavir SARS-CoV-2 3CLpro/3C-like protease protein SARS-COV-2 S protein RBD (194A.A, HEK293, HIS) SARS-COV-2 S protein RBD (HEK293, FC)

SARS-COV-2 S protein RBD (N501Y, K417N, E484K, HEK293, HIS)

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PLpro-IN-3 2-Thiophenecarboxylic acid, 5-[[[5-[5-[1-(2-fluoro[1,1′-biphenyl]-4-yl)ethyl]-1,2,4-oxadiazol-3-yl]-2-methylphenyl]amino]methyl]- 3047093-72-8