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dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate structure

CAS No.: 1459-96-7

Chemical Name:: dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate

Synonyms: o[2.2.2]octane-1,4-dicarboxyL;iMethyl bicyclo[2.2.2]octane-1,4-dicarboxylate;Dimethyl bicyclo[2.2.2]octane-l,4-dicarboxylate;DiMethyl -bicyclo[2.2.2]octan-1,4-dicarboxylate;Dimethyl bioyclo[2.2.2]octane-1,4-dicarboxylate;dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate;2,2-diMethylbicyclo[2.2.2]octane-1,4-dicarboxylate;1,4-dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate;Bicyclo[2.2.2]octane-1,4-dicarboxylic acid dimethyl ester;Dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate - [D13683]

CBNumber:: CB61512357

Molecular Formula:: C12H18O4

Molecular Weight:: 226.27

MDL Number:: MFCD01312167

MOL File:: 1459-96-7.mol

MSDS File:: SDS

Last updated:2026-05-28 03:15:56

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dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate Properties

Boiling point	273.6±20.0 °C(Predicted)
Density	1.205±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Appearance	White to off-white Solid
InChI	InChI=1S/C12H18O4/c1-15-9(13)11-3-6-12(7-4-11,8-5-11)10(14)16-2/h3-8H2,1-2H3
InChIKey	HDOVTVDGSLEUSK-UHFFFAOYSA-N
SMILES	C12(C(OC)=O)CCC(C(OC)=O)(CC1)CC2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
HS Code	2918999090

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR307146	Dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate ≥95%	1459-96-7	1g	$21	2026-06-04	Buy
Apolloscientific	OR307146	Dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate ≥95%	1459-96-7	5g	$45	2026-06-04	Buy
Matrix Scientific	123637	Dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate	1459-96-7	1.00g	$594	2026-05-18	Buy
Synthonix	D13683	Dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate 95+%	1459-96-7	1g	$30	2026-05-06	Buy
Synthonix	D13683	Dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate 95+%	1459-96-7	5g	$50	2026-05-06	Buy

Product number	Packaging	Price	Buy
OR307146	1g	$21	Buy
OR307146	5g	$45	Buy
123637	1.00g	$594	Buy
D13683	1g	$30	Buy
D13683	5g	$50	Buy

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate Chemical Properties, Uses, Production

Uses

Dimethyl Bicyclo[2.2.2]octane-1,4-dicarboxylate is used in preparation of cycloalkanecarboxamides and related compounds as modulators of the integrated stress pathway.

Synthesis

1-(2-CHLOROETHYL)CYCLOHEXANE-1,4-DICARBOXYLIC ACID DIMETHYL ESTER

106004-06-2

1459-96-7

General procedure for the synthesis of dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate from dimethyl 1-(2-chloroethyl)cyclohexane-1,4-dicarboxylate: 2.5 M hexane solution of n-butyllithium (53.6 mL) was added slowly and dropwise to a solution of diisopropylamine (18.7 mL) in tetrahydrofuran (180 mL) cooled to -30 °C. The reaction mixture was stirred between -20°C and -30°C for 20 minutes and subsequently cooled to -78°C. The solution was slowly added to a tetrahydrofuran (440 mL) mixture of dimethyl dicyclo[2.2.2]octane-1,4-dicarboxylate (32 g) and hexamethylphosphorotriamine (90 mL), the product of Step A, that was cooled to -78°C over a period of 30 minutes, ensuring that the temperature of the mixture did not exceed -70°C. Stirring was continued at -78 °C for 25 minutes, followed by slow warming of the reaction mixture to room temperature over 110 hours. After being kept at room temperature for 11 h, the reaction was quenched with saturated aqueous ammonium chloride solution. Volatiles were removed by evaporation and the reaction mixture was diluted with cyclohexane and water. The aqueous phase was separated and extracted three times with cyclohexane. The combined organic phases were washed sequentially with water and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was recrystallized by cyclohexane to give dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate (13.8 g, 50% yield). Mass spectral analysis showed [MH]+ = 227.

References

[1] Australian Journal of Chemistry, 1985, vol. 38, # 11, p. 1705 - 1718
[2] Patent: WO2006/128184, 2006, A2. Location in patent: Page/Page column 164-165
[3] Patent: WO2008/63671, 2008, A2. Location in patent: Page/Page column 177
[4] Synthetic Communications, 2007, vol. 37, # 8, p. 1267 - 1272
[5] Patent: US6649600, 2003, B1. Location in patent: Page/Page column 51-52

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate Preparation Products And Raw materials

Raw materials

1-(2-Chloroethyl)cyclohexane-1,4-dicarboxylic acid dimethyl ester Dispiro[1,3-dithiolane-2,2'-bicyclo[2.2.2]octane-5',2''-[1,3]dithiolane]-1',4'-dicarboxylic acid, 1',4'-dimethyl ester Diisopropylamine Hexamethylphosphoramide Hexane

Tetrahydrofuran n-Butyllithium

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Preparation Products

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate Suppliers

Global Suppliers ( 146)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai AmasPharm Co., Ltd.	021-54540637 18621091017	sales@amaspharm.com	China	787	62
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.	21-57721279 18121011378	sales@shydchem.com.cn	China	998	56
Tianjin Nuokang Pharmaceutical Technology Co., Ltd.	022-23989838 13810451150	44766350@qq.com	China	2727	58
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16306	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
ZhengZhou HuaWen Chemical Co.Ltd	0370-2785118 17550508557	675141927@qq.com	China	3201	55
Baiyin Chengze Chemical Technology Co., Ltd.	+86 943-8535351 13389336721	sales@chengzechem.com	China	300	58

Supplier	Advantage
Shanghai AmasPharm Co., Ltd.	62
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.	56
Tianjin Nuokang Pharmaceutical Technology Co., Ltd.	58
Jia Xing Isenchem Co.,Ltd	66
Accela ChemBio Co.,Ltd.	64
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Syntechem Co.,Ltd	57
ZhengZhou HuaWen Chemical Co.Ltd	55
Baiyin Chengze Chemical Technology Co., Ltd.	58

View Latest Price from dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	Dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate 1459-96-7	$2.00-5.00	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-06-30	dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate 1459-96-7		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2020-01-10	dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate 1459-96-7	$1.00	1g	99%	10000KGS	Career Henan Chemical Co

Dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate
1459-96-7
$2.00-5.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate
1459-96-7
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate
1459-96-7
$1.00
99%
Career Henan Chemical Co

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate Spectrum

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate(1459-96-7)¹HNMR

1459-96-7 (dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate) Related Search:

DiMethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate Bicyclo[2.2.2]Octane-1,4-Dicarboxylic Acid Bicyclo[2.2.2]octane-1,4-dicarboxylic acid hemimethyl ester Bicyclo[1.1.1]pentane-1,3-dicarboxylic acid Bicyclo[2.2.1]heptane-2,5-diol

bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic anhydride Potassium Bicyclo[2.2.1]heptan-2-yltrifluoroborate bicyclo[2.2.1]heptane-1,4-dicarboxylic acid bicyclo[2.2.1]heptan-2-amine DiMethyl bicyclo[2.2.1]heptane-1,4-carboxylate

6-((benzyloxy)methyl)spiro[3.3]heptan-2-one Bicyclo[4.1.0]heptan-2-one bicyclo[2.2.2]octan-1-ylmethanamine hydrochloride 1-Aminomethylbicyclo[2.2.2]octane 4-Hydroxymethylbenzocyclobutene

Bicyclo[3.1.0]hexan-3-ol Bicyclo[2.2.1]heptane-2-carboxylic acid 5-Norbonene-2-methanamine

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DiMethyl -bicyclo[2.2.2]octan-1,4-dicarboxylate Bicyclo[2.2.2]octane-1,4-dicarboxylic acid dimethyl ester 2,2-diMethylbicyclo[2.2.2]octane-1,4-dicarboxylate Bicyclo[2.2.2]octane-1,4-dicarboxylic acid, 1,4-diMethyl ester dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate iMethyl bicyclo[2.2.2]octane-1,4-dicarboxylate 1,4-dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate Dimethyl bioyclo[2.2.2]octane-1,4-dicarboxylate o[2.2.2]octane-1,4-dicarboxyL Dimethyl bicyclo[2.2.2]octane-l,4-dicarboxylate Dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate - [D13683] Bicyclo[2.2.2]octan-1,4-dicarboxylic acid 1,4-dimethyl ester 1459-96-7 1