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ChemicalBook >> CAS DataBase List >>BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER Structure
BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER structure
CAS No.
18720-35-9
Chemical Name:
BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER
Synonyms
4- (methoxy carbonyl) double ring [2.2.2] octane -1- carboxylic acid;o[2.2.2]octane-1-carboxyL;l)bicyclo[2.2.2]octane-1-carboxylic acid;4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-;1-Methyl bicyclo[2.2.2]octane-1,4-dicarboxylate;1-Carboxy-4-(Methoxycarbonyl)bicyclo[2.2.2]octane;1-Methyl bicyclo[2.2.2]heptane-1, 4-dicarboxylate;Bicyclo [2.2.2] octane-1,4-cyclohexanedicarboxylate;4-(Methoxycarbonyl)bicyclo[2.2.2]octan-1-carboxylic Acid;4-(METHOXYCARBONYL)BICYCLO[2.2.2]OCTANE-1-CARBOXYLICACID
CBNumber:
CB3748693
Molecular Formula:
C11H16O4
Molecular Weight:
212.24
MDL Number:
MFCD18459359
MOL File:
18720-35-9.mol
MSDS File:
SDS
Last updated:2026-01-13 11:19:01
Product description Number Pack Size Price
4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid AldrichCPR ANV00226 1g $506
4-(Methoxycarbonyl)bicyclo[2.2.2]octan-1-carboxylic Acid >98.0%(GC)(T) M2855 1g $81
4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid M261285 10g $1075
4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid W4039 100g $1321
4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid 71249 10g $1475
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BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER Properties

Melting point 186.0 to 190.0 °C
Boiling point 322.5±42.0 °C(Predicted)
Density 1.307±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility soluble in Methanol
pka 4.77±0.10(Predicted)
form powder to crystaline
color White to Almost white
InChI InChI=1S/C11H16O4/c1-15-9(14)11-5-2-10(3-6-11,4-7-11)8(12)13/h2-7H2,1H3,(H,12,13)
InChIKey KBZVAQVEHVGIEI-UHFFFAOYSA-N
SMILES C12(C(OC)=O)CCC(C(O)=O)(CC1)CC2
UNSPSC Code 12352106
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H319
Precautionary statements  P301+P310+P330-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36
Safety Statements  26-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2917200090
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Irrit. 2
NFPA 704
0
2 0

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich ANV00226 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid AldrichCPR 18720-35-9 1g $506 2026-03-19 Buy
TCI Chemical M2855 4-(Methoxycarbonyl)bicyclo[2.2.2]octan-1-carboxylic Acid >98.0%(GC)(T) 18720-35-9 1g $81 2026-03-19 Buy
TRC M261285 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid 18720-35-9 10g $1075 2021-12-16 Buy
AK Scientific W4039 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid 18720-35-9 100g $1321 2021-12-16 Buy
Medical Isotopes, Inc. 71249 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid 18720-35-9 10g $1475 2021-12-16 Buy
Product number Packaging Price Buy
ANV00226 1g $506 Buy
M2855 1g $81 Buy
M261285 10g $1075 Buy
W4039 100g $1321 Buy
71249 10g $1475 Buy

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER Chemical Properties,Uses,Production

Uses

4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic Acid has been used as a reactant for the preparation of bicyclo-octyltriazole inhibitors of HSD1 for metabolic syndrome treatment.

Synthesis

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate

1459-96-7

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER

18720-35-9

General procedure for the synthesis of 4-(methoxycarbonyl)bicyclo[2.2.2]octane-1,4-dicarboxylic acid from dimethyl bicyclo[2.2.2]octane-1-carboxylate: a mixture of 4-(methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid (20 g) and potassium hydroxide (5.5 g) in methanol/water (10:1, 106 mL) was heated to reflux overnight. After the reaction was completed, it was cooled to room temperature and concentrated. The residue was diluted with ethyl acetate and extracted with 1N aqueous sodium hydroxide (2 x 100mL). The organic phase was dried with magnesium sulfate, filtered and concentrated to give the starting material as a white solid. The combined aqueous phases were adjusted to pH 1-2 with 2N aqueous hydrochloric acid and extracted with ethyl acetate (4 x 250mL). The combined turbid organic phases were filtered through a slot filter, washed with saturated aqueous sodium chloride, dried over magnesium sulfate, filtered and concentrated to afford 4-(methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid as a colorless solid (13.1 g, 70% yield). Mass spectral analysis showed [MH]+ = 213.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 24, p. 5731 - 5737
[2] Patent: WO2006/128184, 2006, A2. Location in patent: Page/Page column 164-165
[3] Patent: WO2008/63671, 2008, A2. Location in patent: Page/Page column 177-178
[4] Patent: WO2014/159802, 2014, A1. Location in patent: Paragraph 00189
[5] Journal of Medicinal Chemistry, 2009, vol. 52, # 6, p. 1558 - 1568

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER Preparation Products And Raw materials

Raw materials

dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate Potassium hydroxide Methanol Water

Preparation Products

bicyclo[2.2.2]octane-1-carboxylic acid Methyl 4-hydroxybicyclo[2.2.2]octane-1-carboxylate Sodium hydroxy(4-(methoxycarbonyl)bicyclo-[2.2.2]octan-1-yl)methanesulfonate methyl 4-carbamoylbicyclo[2.2.2]octane-1-carboxylate

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER Suppliers

Global( 249)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-13017695106 +86-13676922317 jiuyitime@fdachem.com China 16513 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Klong Industrial Co., Ltd 		0086-519-68231162 info@klongchem.com CHINA 131 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10404 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Time Chemicals CO., Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Klong Industrial Co., Ltd 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58

View Lastest Price from BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER pictures 2025-12-01 BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER
18720-35-9
 US $0.00 / kg 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid pictures 2025-10-13 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid
18720-35-9
 US $2.00-6.00 / kg 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER Spectrum

BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER(18720-35-9)1HNMR

18720-35-9(BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER)Related Search:

3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-amino-,1,1-dimethylethylester, Bicyclo[2.2.2]Octane-1,4-Dicarboxylic Acid DiMethyl bicyclo[2.2.1]heptane-1,4-carboxylate TERT-BUTYL 1-OXO-2,7-DIAZASPIRO[4.5]DECANE-7-CARBOXYLATE Tert-butyl 1,7-diazaspiro[4,4]nonane-1-carboxylate
Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate benzyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 2S-7-Aza-bicyclo[2.2.1]heptane-2,7-dicarboxylic acid 7-tert-butyl ester 7-(TERT-BUTOXYCARBONYL)-1-OXA-2,7-DIAZASPIRO[4.4]NON-2-ENE-3-CARBOXYLIC ACID DI-2-PYRIDYL THIONOCARBONATE
Dibenzyl chloroMethyl phosphate (3aR,6as)-tert-butyl 5-methylenehexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate DIETHYL 2,5-DIOXOBICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLATE TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID MONOMETHYL ESTER BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER
trans-1,4-Cyclohexanedicarboxybic acid 1,4-Cyclohexanedicarboxylic acid dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate

1of4

Bicyclo[2.2.2]octane-1,4-dicarboxylIic acid hemimethyl ester Bicyclo [2.2.2]octane-1,4-dicarboxylic acid, 1-methyl ester Bicyclo[2.2.2]octane-1,4-dicarboxylic acid, monomethyl ester 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1- 1-Carboxy-4-(Methoxycarbonyl)bicyclo[2.2.2]octane 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid, >=98% 4-(Methoxycarbonyl)bicyclo[2.2.2]octan-1-carboxylic Acid BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER 4-(METHOXYCARBONYL)BICYCLO[2.2.2]OCTANE-1-CARBOXYLICACID Bicyclo[2.2.2]octane-1,4-dicarboxylic acid, monomethyl ester 97% 4- (methoxy carbonyl) double ring [2.2.2] octane -1- carboxylic acid Bicyclo[2.2.2]octane-1,4-dicarboxylIic acid hemimethyl este Bicyclo [2.2.2] octane-1,4-cyclohexanedicarboxylate o[2.2.2]octane-1-carboxyL Monomethyl Hydrogen Bicyclo[2.2.2]octane-1,4-dicarboxylate l)bicyclo[2.2.2]octane-1-carboxylic acid 1-Methyl bicyclo[2.2.2]octane-1,4-dicarboxylate 1-Methyl bicyclo[2.2.2]heptane-1, 4-dicarboxylate 18720-35-9 Carboxylic Acids Carboxylic Acids Fused Ring Systems