Otenabant
- CAS No.
- 686344-29-6
- Chemical Name:
- Otenabant
- Synonyms
- CS-1072;otenabant;Otenabant, >=98%;CP945598 free base;Otenabant (CP-945,598);Otenabant, 10 mM in DMSO;CP 945598;OTENABANT;CP945598;CP 945598; CP-945598; CP945598;Otenabant (CP-945598 free base);1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxamide
- CBNumber:
- CB61518526
- Molecular Formula:
- C25H25Cl2N7O
- Molecular Weight:
- 510.42
- MDL Number:
- MOL File:
- 686344-29-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Otenabant 99.63% | CS-1279 | 5mg | $54 |
| Otenabant 99.63% | CS-1279 | 10mg | $87 |
| Otenabant 99.63% | CS-1279 | 25mg | $173 |
| Otenabant 99.63% | CS-1279 | 50mg | $282 |
| Otenabant 99.63% | CS-1279 | 100mg | $455 |
| More product size | |||
| Boiling point | 757.9±70.0 °C(Predicted) |
|---|---|
| Density | 1.46 |
| storage temp. | Store at -20°C |
| solubility | DMSO : 100 mg/mL (195.92 mM; Need ultrasonic) |
| form | Powder |
| pka | 16.30±0.20(Predicted) |
| color | White to off-white |
| FDA UNII | J8211Y53EF |
Otenabant price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1279 | Otenabant 99.63% | 686344-29-6 | 5mg | $54 | 2026-06-04 | Buy |
| ChemScene | CS-1279 | Otenabant 99.63% | 686344-29-6 | 10mg | $87 | 2026-06-04 | Buy |
| ChemScene | CS-1279 | Otenabant 99.63% | 686344-29-6 | 25mg | $173 | 2026-06-04 | Buy |
| ChemScene | CS-1279 | Otenabant 99.63% | 686344-29-6 | 50mg | $282 | 2026-06-04 | Buy |
| ChemScene | CS-1279 | Otenabant 99.63% | 686344-29-6 | 100mg | $455 | 2026-06-04 | Buy |
Otenabant Chemical Properties,Uses,Production
Uses
Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.
Biological Activity
Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with a Ki of 0.7 nM, more than 1000-fold selective for CB2.
in vitro
Otenabant HCl has low affinity with K i of 7.6 μM for human CB2 receptors. It inhibits CB1 receptor with moderate unbound microsomal clearance, low hERG affinity, and adequate CNS penetration. < /p>
in vivo
Otenabant acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation. It (10 mg/kg, po) promotes a 9%, vehicle adjusted weight loss in a 10 day weight loss study in diet-induced obese mice. Otenabant HCl reverses four cannabinoid agonistmediated behaviors (locomotor activity, hypothermia, analgesia, and catalepsy) following administration of the synthetic CB1 receptor agonist CP-55940. And Otenabant HCl exhibits dose-dependent anorectic activity in a model of acute food intake in rodents and increased energy expenditure and fat oxidation.
target
Ki: 0.7 nM (CB1)
References
[1] John R. Hadcock, et al. In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochemical and Biophysical Research Communications, 2010; 394;366-371.
[2] Griffith DA, et al. Discovery of 1-[9-(4-chlorophenyl) -8-(2-chlorophenyl)- 9H-purin-6-yl] -4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. JMedChem. 2009 ;5
Otenabant Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9035 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +86-15988602810 | sales@anbuchem.com | China | 5812 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9930 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Lastest Price from Otenabant manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Otenabant
686344-29-6
|
$30.00-65.00 | 99.44% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-13 | Otenabant
686344-29-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-09 | Otenabant
686344-29-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
