(R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride
- CAS No.
- 1004538-34-4
- Chemical Name:
- (R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride
- Synonyms
- (R)-3-AMINO-1-N-BOC-PYRROLIDINE-HCl;(R)-1-Boc-3-amino-pyrrolidine hydrochloride;(R)-TERT-BUTYL 3-AMINOPYRROLIDINE-1-CARBOXYLATE HCL;3-amino-1-pyrrolidinecarboxylic acid tert-butyl ester;(R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride;(3R)-3-Aminopyrrolidine-1-carboxylic acid tert-butyl ester HCl;3-Amino-1-pyrrolidinecarboxylic acid tert-butyl ester hydrochloride;(R)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine hydrochloric acid salt;(3R)-3-amino-1-Pyrrolidinecarboxylic acid 1,1-dimethylethyl ester hydrochloride (1:1);1-Pyrrolidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, hydrochloride (1:1), (3R)-
- CBNumber:
- CB61570588
- Molecular Formula:
- C9H19ClN2O2
- Molecular Weight:
- 222.71236
- MDL Number:
- MFCD08061978
- MOL File:
- 1004538-34-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
(R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | B52212 | (R)-tert-Butyl 3-aminopyrrolidine-1-carboxylate hydrochloride 95+% | 1004538-34-4 | 1g | $70 | 2026-05-06 | Buy |
| Synthonix | B52212 | (R)-tert-Butyl 3-aminopyrrolidine-1-carboxylate hydrochloride 95+% | 1004538-34-4 | 5g | $100 | 2026-05-06 | Buy |
| Synthonix | B52212 | (R)-tert-Butyl 3-aminopyrrolidine-1-carboxylate hydrochloride 95+% | 1004538-34-4 | 10g | $140 | 2026-05-06 | Buy |
| Synthonix | B52212 | (R)-tert-Butyl 3-aminopyrrolidine-1-carboxylate hydrochloride 95+% | 1004538-34-4 | 25g | $230 | 2026-05-06 | Buy |
| Synthonix | B52212 | (R)-tert-Butyl 3-aminopyrrolidine-1-carboxylate hydrochloride 95+% | 1004538-34-4 | 100g | $920 | 2026-05-06 | Buy |
(R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride Chemical Properties, Uses, Production
Synthesis
147081-49-0
1004538-34-4
Step 10-3: Preparation of (R)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine hydrochloride: according to the method described in Step 10-1, 2.60 g of (R)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine (chemical purity: 48.7 area %, optical purity: 96.6% ee, relative to the (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester hydrochloride HPLC area value, containing 48.4% optically active 1-(tert-butoxycarbonyl)-3-methoxypyrrolidine (represented by formula (9)) and 31.9% 1-(tert-butoxycarbonyl)-3,4-dehydropyrrolidine (represented by formula (10)) was dissolved in 30 mL of isopropanol. To this solution was added 1.39 g of concentrated hydrochloric acid followed by concentration under reduced pressure. To the concentrate was added 50 mL of ethyl acetate and stirred at 22°C for 30 minutes. After continued stirring for 30 minutes under ice bath cooling, the crystals were collected by filtration under reduced pressure. The crystals were washed with 20 mL of ethyl acetate and subsequently dried under vacuum to afford 2.51 g of white solid (R)-tert-butyl (R)-3-aminopyrrolidine-1-carboxylate hydrochloride (chemical purity: 99.6 area %, yield: 95%, optical purity: 99.7% ee). It was confirmed by HPLC analysis that optically active 1-(tert-butoxycarbonyl)-3-methoxypyrrolidine represented by formula (9) and 1-(tert-butoxycarbonyl)-3,4-dehydropyrrolidine represented by formula (10) were not detected.
References
[1] Patent: EP2050735, 2009, A1. Location in patent: Page/Page column 22
(R)-tert-butyl 3-aminopyrrolidine-1-carboxylate hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Acesys Pharmatech | 18860950986 | tangmanman@zenjipharma.com | China | 1731 | 55 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 86-574-27787657 | info@dearchem.com | China | 4607 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 | sales@mreda.com.cn | China | 19323 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
