2-Bromo-4-tert-butylaniline
- CAS No.
- 103273-01-4
- Chemical Name:
- 2-Bromo-4-tert-butylaniline
- Synonyms
- BUTTPARK 83\07-24;2-BROMO-4-TERT-BUTYLANILINE;2-BROMO-4-TERT-BUTYL-PHENYLAMINE;1-Amino-2-brom-4-tert-butylbenzol;1-Amino-2-bromo-4-(tert-butyl)benzene;2-Bromo-4-(1,1-dimethylethyl)benzenamine;Benzenamine,2-bromo-4-(1,1-dimethylethyl)-
- CBNumber:
- CB6186926
- Molecular Formula:
- C10H14BrN
- Molecular Weight:
- 228.13
- MDL Number:
- MFCD00052693
- MOL File:
- 103273-01-4.mol
- MSDS File:
- SDS
| Boiling point | 265°C(lit.) |
|---|---|
| Density | 1.306±0.06 g/cm3(Predicted) |
| refractive index | 1.5680 to 1.5720 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 2.86±0.10(Predicted) |
| form | clear liquid |
| color | Colorless to Red to Green |
| InChI | InChI=1S/C10H14BrN/c1-10(2,3)7-4-5-9(12)8(11)6-7/h4-6H,12H2,1-3H3 |
| InChIKey | OLKYFBNIFKQRIZ-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(C(C)(C)C)C=C1Br |
| CAS DataBase Reference | 103273-01-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HS Code | 2921490090 | |||||||||
| NFPA 704 |
|
2-Bromo-4-tert-butylaniline price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B5325 | 2-Bromo-4-(tert-butyl)aniline >98.0%(GC)(T) | 103273-01-4 | 5g | $82 | 2026-04-30 | Buy |
| TCI Chemical | B5325 | 2-Bromo-4-(tert-butyl)aniline >98.0%(GC)(T) | 103273-01-4 | 25g | $241 | 2026-04-30 | Buy |
| Apolloscientific | OR19485 | 2-Bromo-4-(tert-butyl)aniline 94% | 103273-01-4 | 5g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR19485 | 2-Bromo-4-(tert-butyl)aniline 94% | 103273-01-4 | 25g | $82 | 2026-06-04 | Buy |
| Activate Scientific | AS119607 | 2-Bromo-4-(tert-butyl)aniline 96% | 103273-01-4 | 5g | $22 | 2026-06-04 | Buy |
2-Bromo-4-tert-butylaniline Chemical Properties, Uses, Production
Chemical Properties
Yellow liquid
Uses
2-Bromo-4-tert-butylaniline is commonly employed in organic synthesis for the production of various compounds, including 8-Bromo-6-tert-butylquinoline. It can also be used in the production of dyes and pigments, pharmaceutical intermediates, and agrochemicals.
Preparation
4-(tert-butyl)aniline (50.0 g, 335.1 mmol), dissolved in 1.1 L of acetonitrile, was added to a flask. After cooling the mixture to 0 ℃, NBS (59.6 g, 335.1 mmol) was added and the temperature was raised to room temperature for 12 hours. After that, water (800 mL) was added, extracted with dichloromethane, and the solvent was concentrated under reduced pressure. The dichloromethane (700 mL) was added to the mixture, washed with 400 mL of 2N NaOH, filtered through a silica pad, and the solvent was concentrated under reduced pressure to obtain 2-Bromo-4-tert-butylaniline.
Hazard
H302 (33.33%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (33.33%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H332 (33.33%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Synthesis
769-92-6
103273-01-4
Under strict light protection, 4-tert-butylaniline (10 g, 68 mmol) was dissolved in DMF (150 mL) and cooled to 0 °C. To this solution, N-bromosuccinimide (NBS, 12.1 g, 68 mmol) was slowly added and stirred continuously at 0 °C for 30 min. Subsequently, the ice bath was removed to bring the reaction mixture to room temperature and stirring was continued for 18 hours. Upon completion of the reaction, the mixture was poured into water (300 mL) and extracted with dichloromethane (CH2Cl2). The organic phases were combined, dried with anhydrous magnesium sulfate (MgSO4) and filtered. The filtrate was evaporated under reduced pressure to give a dark brown tarry crude product. Purification by column chromatography (eluent: petroleum ether/ethyl acetate=20:1) afforded the colorless oily target product 2-bromo-4-(tert-butyl)aniline (13.5 g, 87% yield). Thin-layer chromatography (TLC) analysis showed an Rf value of 0.69 (unfolding agent: petroleum ether/ethyl acetate=5:1).1H-NMR (CDCl3, 300 MHz) data were as follows: δ 7.43 (t, J=1.2 Hz, 1H), 7.14 (m, 1H), 6.72 (d, J=8.1 Hz, 1H), 3.96 (br, 2H). 1.30 (s, 9H).
References
[1] Heterocycles, 2006, vol. 68, # 12, p. 2635 - 2645
[2] Angewandte Chemie - International Edition, 2014, vol. 53, # 1, p. 178 - 183
[3] Angew. Chem., 2014, vol. 126, # 1, p. 182 - 187,6
[4] Tetrahedron Letters, 2012, vol. 53, # 39, p. 5248 - 5252
[5] Journal of Fluorine Chemistry, 2015, vol. 180, p. 33 - 39
2-Bromo-4-tert-butylaniline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Convergence Chemical Co. LTD | 13393710386 | 3941078109@qq.com | China | 9860 | 58 |
| Jalor-Chem co.,LTD | 0510-0510-86396359 13382276200 | sales@jalor-chem.com | China | 1011 | 56 |
| Zhengzhou HQ Material Co., Ltd. | 0371-67759225 13526468238 | sale@hqmat.com | China | 1408 | 58 |
| Baynoe chem Co.,Ltd | 15000719740 15572194250 | dosales@baynoe.com | China | 1000 | 58 |
| Hubei Xishaonian biotechnology co., ltd | 0711-3700636 18827410479 | xujin@boronicgroup.com | China | 50 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ZHIWE CHEMTECH CO LTD | 021-20221225 13917446399 | zwchem@163.com | China | 522 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
View Latest Price from 2-Bromo-4-tert-butylaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-08 | 2-Bromo-4-tert-butylaniline
103273-01-4
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2023-04-21 | 2-BROMO-4-TERT-BUTYLANILINE
103273-01-4
|
1kg | 98%+ | 1000kg | Jiangsu Nata Opto-electronic Material Co.,Ltd. |
-
- 2-Bromo-4-tert-butylaniline
103273-01-4
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-BROMO-4-TERT-BUTYLANILINE
103273-01-4
- 98%+
- Jiangsu Nata Opto-electronic Material Co.,Ltd.
