Reversan
- CAS No.
- 313397-13-6
- Chemical Name:
- Reversan
- Synonyms
- CBLC4H10;Reversan;Reversan, MRP1 and P-glycoprotein inhibitor;N-(3-Morpholinopropyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide;N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(4-morpholinyl)propyl]-5,7-diphenyl-;5,7-Diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-morpholin-4-yl-propyl)-amide;ReversanQ: What is Reversan Q: What is the CAS Number of Reversan Q: What is the storage condition of Reversan Q: What are the applications of Reversan
- CBNumber:
- CB61883226
- Molecular Formula:
- C26H27N5O2
- Molecular Weight:
- 441.52
- MDL Number:
- MFCD01528184
- MOL File:
- 313397-13-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 176-180°C |
|---|---|
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMSO: ≥8mg/mL at ~60°C |
| pka | 11.33±0.46(Predicted) |
| form | powder |
| color | faint yellow to yellow |
| InChI | 1S/C26H27N5O2/c32-26(27-12-7-13-30-14-16-33-17-15-30)22-19-28-31-24(21-10-5-2-6-11-21)18-23(29-25(22)31)20-8-3-1-4-9-20/h1-6,8-11,18-19H,7,12-17H2,(H,27,32) |
| InChIKey | JTRXWCLQFAZHGP-UHFFFAOYSA-N |
| SMILES | O=C(NCCCN1CCOCC1)c2cnn3c(cc(nc23)-c4ccccc4)-c5ccccc5 |
| UNSPSC Code | 12161501 |
| NACRES | NA.77 |
Reversan price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0173 | Reversan ≥98% (HPLC) | 313397-13-6 | 5mg | $143 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0173 | Reversan ≥98% (HPLC) | 313397-13-6 | 25mg | $572 | 2026-04-30 | Buy |
| Usbiological | 256447 | Reversan Asreported | 313397-13-6 | 10mg | $480 | 2026-06-03 | Buy |
| Usbiological | 256447 | Reversan Asreported | 313397-13-6 | 50mg | $1338 | 2026-06-03 | Buy |
| TRC | TRC-R279800-5MG | Reversan | 313397-13-6 | 5mg | $51 | 2026-06-03 | Buy |
Reversan Chemical Properties, Uses, Production
Uses
Reversan represents a new class of nontoxic MRP1 inhibitor, which may be clinically useful for the treatment of neuroblastoma.
Biological Activity
Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin , vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Displays at activity on MRP2, MRP3, MRP5 and MRP5 transporters.
storage
Store at -20°C
Reversan Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | 13186333400 19299362551 | cuichengbio@163.com | China | 1932 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9778 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
