Cannabidivarol

Physiological activity

Cannabidivarin, also known as cannabidivarol or CBDV, is a non-psychoactive cannabinoid found within Medical Cannabis. It is one of over 100 cannabinoids identified from the Cannabis plant that can modulate the physiological activity of cannabis, or marijuana 3. Compared to its homolog, Cannabidiol, CBDV is shortened by two methyl (CH2) groups on its side chain. Notably, both Cannabidiol and CBDV have demonstrated anticonvulsant activity in animal and human models and are demonstrating promising clinical trial results. 

Effects

Cannabidivarol（CBDV） has anticonvulsant effects.

Uses

The Certified Reference Material (CRM) in solution can also be used as follows:

• Determination of eight cannabinoids in eight hemp samples and 12 forensic cannabis samples using reversed phase-high-pressure liquid chromatography (RP-HPLC) in combination with UV detector
• Analysis of 13 oil samples obtained from hemp for seven major cannabinoids using high-performance liquid chromatography (HPLC) combined with UV detection
• Development of a rapid liquid chromatographic (LC) method for the separation and identification of cannabidiol, cannabidivarin, Δ9-tetrahydrocannabivarin, and cannabigerol in mouse tissue samples in combination with tandem mass spectrometry (MS/MS)
• Detection and quantification of cannabidiol, tetrahydrocannabinol, cannabinol, tetrahydrocannabivarin, cannabidivarin, and cannabigerol by liquid chromatography coupled with mass spectrometry in positive electrospray ionization (ESI) mode from hemp plants
• Development and validation of an LC method combined with a UV detector for impurity analysis of cannabidivarin and cannabidibutol in cannabidiol obtained from hemp extracts

Definition

ChEBI: Cannabidivarin is a monoterpenoid.

General Description

Cannabidivarin (CBDV) is a non-psychoactive cannabinoid found in Cannabis that reportedly has therapeutic efficacy in the treatment of pain, mood disorders, and inflammatory diseases. This certified Snap-N-Spike solution is suitable for cannabidivarin testing methods by GC/MS, LC/MS or HPLC for applications in clinical toxicology, testing of Cannabis potency or impurity profiling, pharmaceutical research, forensic analysis, and urine drug testing. Cerilliant solution Certified Reference Materials (CRMs) of cannabinoids are supplied in a convenient, quantitative, US DEA-exempt solution format and with TK#s for Canadian customers.

References

[1] AJ HILL. Cannabidivarin is anticonvulsant in mouse and rat[J]. British Journal of Pharmacology, 2012, 167 8: 1629-1642. DOI: 10.1111/j.1476-5381.2012.02207.x
[2] CINZIA CITTI . Analysis of impurities of cannabidiol from hemp. Isolation, characterization and synthesis of cannabidibutol, the novel cannabidiol butyl analog[J]. Journal of pharmaceutical and biomedical analysis, 2019, 175: Article 112752. DOI: 10.1016/j.jpba.2019.06.049
[3] HANNAH C. HUFF. Differential Interactions of Selected Phytocannabinoids with Human CYP2D6 Polymorphisms[J]. Biochemistry Biochemistry, 2021, 60 37: 2749-2760. DOI: 10.1021/acs.biochem.1c00158