4-Nitro-2-trifluoromethylphenol
- CAS No.
- 1548-61-4
- Chemical Name:
- 4-Nitro-2-trifluoromethylphenol
- Synonyms
- 4-Nitro-2-trifluoromethylphenol;2-Trifluoromethyl-4-nitrophenol;4-Nitro-2-(trifluoromethyl)benzenol;Phenol, 4-nitro-2-(trifluoromethyl)-;1548-61-4 4-Nitro-2-(trifluoromethyl)benzenol
- CBNumber:
- CB62367187
- Molecular Formula:
- C7H4F3NO3
- Molecular Weight:
- 207.11
- MDL Number:
- MFCD11100972
- MOL File:
- 1548-61-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315; H319; H335 |
| Precautionary statements | P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501 |
| RIDADR | 2811 |
| HazardClass | IRRITANT |
| PackingGroup | Ⅲ |
| Limited Quantities | 0.5 Kg (solid) |
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) |
4-Nitro-2-trifluoromethylphenol price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 285447 | 4-Nitro-2-(trifluoromethyl)benzenol Asreported | 1548-61-4 | 250mg | $449 | 2026-06-03 | Buy |
| Usbiological | 285447 | 4-Nitro-2-(trifluoromethyl)benzenol Asreported | 1548-61-4 | 500mg | $644 | 2026-06-03 | Buy |
| Usbiological | 285447 | 4-Nitro-2-(trifluoromethyl)benzenol Asreported | 1548-61-4 | 1g | $908 | 2026-06-03 | Buy |
| Usbiological | 285447 | 4-Nitro-2-(trifluoromethyl)benzenol Asreported | 1548-61-4 | 2g | $1290 | 2026-06-03 | Buy |
| Usbiological | 285447 | 4-Nitro-2-(trifluoromethyl)benzenol Asreported | 1548-61-4 | 5g | $1858 | 2026-06-03 | Buy |
4-Nitro-2-trifluoromethylphenol Chemical Properties, Uses, Production
Synthesis Reference(s)
The Journal of Organic Chemistry, 27, p. 4660, 1962 DOI: 10.1021/jo01059a515
Synthesis
654-76-2
1548-61-4
The general procedure for the synthesis of 2-trifluoromethyl-4-nitrophenol from 2-methoxy-5-nitrobenzotrifluoride was as follows: 6-methoxy-5-nitrobenzotrifluoride (24.73 g, 110.7 mmol) was dissolved in acetic acid (260 mL), 62% aqueous hydrobromic acid (130 mL) was added, and the reaction was heated to reflux for 96 hours. After the reaction was completed, it was cooled to room temperature and most of the solvent was removed by evaporation. The residue was dissolved in water and extracted with saturated NaHCO3 solution and ether (3×). The organic phases were combined, washed with 10% NaCl aqueous solution and dried over anhydrous Na2SO4. The solvent was evaporated under reduced pressure to give 19.27 g (83% yield) of 4-nitro-2-trifluoromethylphenol as a yellow solid. Mass spectrum (MS): 207 (M+), melting point (MP): 103-104 °C.
References
[1] Journal of Materials Chemistry, 2009, vol. 19, # 39, p. 7208 - 7215
[2] Patent: US2004/248951, 2004, A1. Location in patent: Page 16
[3] Patent: WO2007/4749, 2007, A1. Location in patent: Page/Page column 150
[4] Journal of Organic Chemistry, 1962, vol. 27, p. 4660 - 4662
[5] Patent: WO2005/80340, 2005, A1. Location in patent: Page/Page column 50
4-Nitro-2-trifluoromethylphenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Yurui (Shanghai) Chemical Co., Ltd. | 02150456736 18602143071 | Jenny@riyngroup.com | China | 500 | 30 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
View Latest Price from 4-Nitro-2-trifluoromethylphenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-12 | 4-Nitro-2-trifluoromethylphenol
1548-61-4
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
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- 4-Nitro-2-trifluoromethylphenol
1548-61-4
- $1.00
- 99%
- Career Henan Chemical Co
